Protein Alignment NetB and ntn1

DIOPT Version :10

• Sequence 1: NP_511155.1
• Gene: NetB / 32400
• FlyBaseID: FBgn0015774
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: XP_031750355.1
• Gene: ntn1 / 100493770
• XenbaseID: XB-GENE-989335
• Length: 602
• Species: Xenopus tropicalis
• Alignment Length: 810
• Identity: 328/810 - (40%)
• Similarity: 430/810 - (53%)
• Gaps: 244/810 - (30%)

  Fly    11 LLLPIILALAIGSSAA-----GISSN---------DPCYFE-GKPRKCLPSFVNAAYGNPVQASS 60
            |..|::|.|...|..|     |...|         ||||.| |.||:|:|.|||:|:|..|:.|.
 Frog     2 LRCPLVLVLLSLSCTAQEGRGGYGMNMFSIQTSQPDPCYDENGNPRRCIPDFVNSAFGKEVRVSG 66

  Fly    61 VCGAQQPERYCELLRDG-----NAGECRSCEQQR-YGPAALTDLNNPSNVTCWRSGAVNVPHDPD 119
            .|| :.|.|||.:...|     |...|.:.:.:| :.|:.|||||||.|:|||:|       :..
 Frog    67 TCG-KPPSRYCVVTEKGEDRFRNCHICNTSDPKRAHPPSFLTDLNNPHNLTCWQS-------ENY 123

  Fly   120 SAPPDNVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRP 184
            ...|.|||||||||||:|:||:||.||  ||||:|:|||||.|:|::|.||||||:||:|.|.:|
 Frog   124 IQYPQNVTLTLSLGKKFEVTYVSLQFC--SPRPESMAIFKSMDYGKSWVPFQFYSTQCRKMYNKP 186

  Fly   185 DRAKISKFNEQEARCINSQHD----TGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVV 245
            ::|.|:|.|||||.|.:|..|    :||.   .||:||:|||||:|.|:|.|||||||||||:||
 Frog   187 NKAIITKQNEQEAICTDSHTDMHPLSGGL---IAFSTLDGRPSAHDFDNSPVLQDWVTATDIKVV 248

  Fly   246 FHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEE 310
            |.||            :.|.||        .:||::|..|
 Frog   249 FSRL------------HTFGDE--------NEDDSELARD------------------------- 268

  Fly   311 PKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPS 375
                                                                             
 Frog   269 ----------------------------------------------------------------- 268

  Fly   376 TAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSA 440
                           |..|||||..||||||||||||.||           .|:||
 Frog   269 ---------------SYFYAVSDLQVGGRCKCNGHASRCV-----------KDRDD--------- 298

  Fly   441 PSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHAR 505
                             .:.|.||||||||||:|||||::||||.|||..:||||..|.||.|||
 Frog   299 -----------------NLVCDCKHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHAR 346

  Fly   506 RCRFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTG 570
            |||||:||:|||||.|||||.||:|:|.||:||||:||||||.|||..|||.||.|||||||:.|
 Frog   347 RCRFNMELFKLSGRRSGGVCLNCRHNTAGRHCHYCKEGYYRDMTKPITHRKACKACDCHPVGAAG 411

  Fly   571 KTCNHLSGQCPCKEGVTGLTCNRCARGYQQTRSHVAPCIKVPTNANMIQAESAGGGGGGGTGDYK 635
            ||||..:||||||:||||:||||||:||||:||.:|||||:|    ::...:|
 Frog   412 KTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIP----VVPPTTA------------ 460

  Fly   636 DGGGSQVEEMKKYCGKCKASPKKL--NLNKFCMEDYAILAKVIGHDRASQDISTEKFSIERQNEI 698
               .|.:||.......||||..||  |:.|:|.:|||:...::..|:|              .:.
 Frog   461 ---ASSMEEPADCDAYCKASKGKLKINMKKYCKKDYAVQIHILKADKA--------------GDW 508

  Fly   699 YKYEINIQTIFKRNPMSGTTSSLLGRGNMMLLVPRKSIECQCPKIKLNKSYLILGRDSEAAP--G 761
            :|:.:|:.:::|:    ||  :.:.||:..|.:..|.|.|:|||:|..|.||:||.|.::..  |
 Frog   509 WKFTVNVISVYKQ----GT--NRIRRGDQNLWIRAKDIACKCPKLKPTKKYLLLGNDEDSPDQNG 567

  Fly   762 YLAIGPSSVVLEWKDEWSLRMKRFQRRARK 791
            .:| ..||:|::|:|.|:.|:::||:|.:|
 Frog   568 VVA-DKSSLVIQWRDTWARRLRKFQQREKK 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_511155.1	LamNT	37..261	CDD:214532	120/234 (51%)
		EGF_Lam	<458..484	CDD:238012	18/25 (72%)
		EGF_Lam	498..555	CDD:238012	42/56 (75%)
		EGF_Lam	560..608	CDD:238012	35/47 (74%)
		NTR_netrin-1_like	661..791	CDD:239634	40/131 (31%)
ntn1	XP_031750355.1	LamNT	44..281	CDD:214532	133/374 (36%)
		EGF_Lam	282..327	CDD:238012	34/81 (42%)
		Laminin_EGF	339..399	CDD:395007	45/59 (76%)
		Laminin_EGF	402..>439	CDD:395007	28/36 (78%)
		NTR_netrin-1_like	485..599	CDD:239634	41/133 (31%)