DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and LOC100493770

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_031750355.1	Gene:	LOC100493770 / 100493770	-ID:	-	Length:	602	Species:	Xenopus tropicalis

Alignment Length:	810	Identity:	328/810 - (40%)
Similarity:	430/810 - (53%)	Gaps:	244/810 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLPIILALAIGSSAA-----GISSN---------DPCYFE-GKPRKCLPSFVNAAYGNPVQASS 60
            |..|::|.|...|..|     |...|         ||||.| |.||:|:|.|||:|:|..|:.|.
Frog     2 LRCPLVLVLLSLSCTAQEGRGGYGMNMFSIQTSQPDPCYDENGNPRRCIPDFVNSAFGKEVRVSG 66

  Fly    61 VCGAQQPERYCELLRDG-----NAGECRSCEQQR-YGPAALTDLNNPSNVTCWRSGAVNVPHDPD 119
            .|| :.|.|||.:...|     |...|.:.:.:| :.|:.|||||||.|:|||:|       :..
Frog    67 TCG-KPPSRYCVVTEKGEDRFRNCHICNTSDPKRAHPPSFLTDLNNPHNLTCWQS-------ENY 123

  Fly   120 SAPPDNVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRP 184
            ...|.|||||||||||:|:||:||.||  ||||:|:|||||.|:|::|.||||||:||:|.|.:|
Frog   124 IQYPQNVTLTLSLGKKFEVTYVSLQFC--SPRPESMAIFKSMDYGKSWVPFQFYSTQCRKMYNKP 186

  Fly   185 DRAKISKFNEQEARCINSQHD----TGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVV 245
            ::|.|:|.|||||.|.:|..|    :||.   .||:||:|||||:|.|:|.|||||||||||:||
Frog   187 NKAIITKQNEQEAICTDSHTDMHPLSGGL---IAFSTLDGRPSAHDFDNSPVLQDWVTATDIKVV 248

  Fly   246 FHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEE 310
            |.||            :.|.||        .:||::|..|
Frog   249 FSRL------------HTFGDE--------NEDDSELARD------------------------- 268

  Fly   311 PKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPS 375

Frog   269 ----------------------------------------------------------------- 268

  Fly   376 TAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSA 440
                           |..|||||..||||||||||||.||           .|:||
Frog   269 ---------------SYFYAVSDLQVGGRCKCNGHASRCV-----------KDRDD--------- 298

  Fly   441 PSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHAR 505
                             .:.|.||||||||||:|||||::||||.|||..:||||..|.||.|||
Frog   299 -----------------NLVCDCKHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHAR 346

  Fly   506 RCRFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTG 570
            |||||:||:|||||.|||||.||:|:|.||:||||:||||||.|||..|||.||.|||||||:.|
Frog   347 RCRFNMELFKLSGRRSGGVCLNCRHNTAGRHCHYCKEGYYRDMTKPITHRKACKACDCHPVGAAG 411

  Fly   571 KTCNHLSGQCPCKEGVTGLTCNRCARGYQQTRSHVAPCIKVPTNANMIQAESAGGGGGGGTGDYK 635
            ||||..:||||||:||||:||||||:||||:||.:|||||:|    ::...:|
Frog   412 KTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIP----VVPPTTA------------ 460

  Fly   636 DGGGSQVEEMKKYCGKCKASPKKL--NLNKFCMEDYAILAKVIGHDRASQDISTEKFSIERQNEI 698
               .|.:||.......||||..||  |:.|:|.:|||:...::..|:|              .:.
Frog   461 ---ASSMEEPADCDAYCKASKGKLKINMKKYCKKDYAVQIHILKADKA--------------GDW 508

  Fly   699 YKYEINIQTIFKRNPMSGTTSSLLGRGNMMLLVPRKSIECQCPKIKLNKSYLILGRDSEAAP--G 761
            :|:.:|:.:::|:    ||  :.:.||:..|.:..|.|.|:|||:|..|.||:||.|.::..  |
Frog   509 WKFTVNVISVYKQ----GT--NRIRRGDQNLWIRAKDIACKCPKLKPTKKYLLLGNDEDSPDQNG 567

  Fly   762 YLAIGPSSVVLEWKDEWSLRMKRFQRRARK 791
            .:| ..||:|::|:|.|:.|:::||:|.:|
Frog   568 VVA-DKSSLVIQWRDTWARRLRKFQQREKK 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	120/234 (51%)
		EGF_Lam	<458..484	CDD:238012	18/25 (72%)
		EGF_Lam	498..555	CDD:238012	42/56 (75%)
		EGF_Lam	560..608	CDD:238012	35/47 (74%)
		NTR_netrin-1_like	661..791	CDD:239634	40/131 (31%)
LOC100493770	XP_031750355.1	LamNT	44..281	CDD:214532	133/374 (36%)
		EGF_Lam	282..327	CDD:238012	34/81 (42%)
		Laminin_EGF	339..399	CDD:395007	45/59 (76%)
		Laminin_EGF	402..>439	CDD:395007	28/36 (78%)
		NTR_netrin-1_like	485..599	CDD:239634	41/133 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	105	1.000	Domainoid score	I6558
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	619	1.000	Inparanoid score	I870
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003523
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1381
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.050