Protein Alignment NetB and ntng2

DIOPT Version :10

• Sequence 1: NP_511155.1
• Gene: NetB / 32400
• FlyBaseID: FBgn0015774
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: XP_004916725.1
• Gene: ntng2 / 100489740
• XenbaseID: XB-GENE-6032766
• Length: 659
• Species: Xenopus tropicalis
• Alignment Length: 619
• Identity: 143/619 - (23%)
• Similarity: 229/619 - (36%)
• Gaps: 180/619 - (29%)

  Fly    62 CGAQQPERYCE-----LLRDGNAGEC-RSCEQQRYGPAALTDLNNPSNVTCWRSGAVNVPHDPDS 120
            || ..|||:|.     |..|    || .|.....:.|:.:.|.......|.|:|  |.....|:
 Frog    61 CG-NPPERFCTHENPYLCSD----ECDASNPDLAHPPSLMFDKEKEGLATYWQS--VTWKRYPE- 117

  Fly   121 APPDNVTLTLSLGKKYELT-YISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRP 184
              |....:|||..|..||| .|.::|  ...||.::.:.||.|:|:||.|:|:|:..|.:.:|.|
 Frog   118 --PLVANITLSWNKSLELTDDIVVTF--EYGRPTAMMLEKSLDYGRTWHPYQYYADDCMEAFGMP 178

  Fly   185 DRAKISKFNEQEAR---CINSQHDTGGAAQ----------RFA-FNTLEGRPSAN---DLDSSLV 232
            .| |:.......|.   |........|:.:          ||| |...:.|...|   .::|:..
 Frog   179 PR-KVRDLAASSANRVLCTEEYSRWAGSKKEKDVRFEVRDRFAIFAGPDLRKMENLYLRMESAKG 242

  Fly   233 LQDWVTATDIRVVFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQD 297
            |:|:.|.||:|:   ||..|              .:||:..:.|                 ||..
 Frog   243 LKDFFTLTDLRL---RLLRP--------------ALGGTYVQRE-----------------NLYK 273

  Fly   298 NDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYE-----KHYQSKLAATT 357
            ...|.:.::.....|       .:||.:..:..:..::.:.:|..:..:     |:::||...:
 Frog   274 YFYAISNFEVVARCK-------CNLHANACNFRDGALQCECEHNTTGQDCGRCKKNFRSKSWRS- 330

  Fly   358 PPQQPPKVTPPGKVTPPSTAAPSAAASAVT-------------LPISQHYAVSDFAVGGRCKCNG 409
                       |..||....:|:|.|:|.|             |||...|..:...|
 Frog   331 -----------GSYTPTPNGSPNACAAAGTAFGTVDPILERTDLPIIPEYTENKRVV-------- 376

  Fly   410 HAS------------------------ECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRS 450
            ..|                        |...|.:||.            :.|.:.||..|....:
 Frog   377 QMSLTPPVLDQKPKLPEKIQAAPPVLRELAVTPASGK------------KQTKTVPSPVNRQMTT 429

  Fly   451 TQMSA-KLTMTCA--------------CKH-NTAGPECERCKPFYFDRPWGRATDNDANECKMCQ 499
            |..|: |.|.|.|              .|| .||.|:    .....:....:.::........|:
 Frog   430 TPASSKKQTKTAAPSISRELPLPPASGKKHTKTAAPK----SSIPLEPSTVKVSETLGKSVTDCE 490

  Fly   500 CNGHARRCRFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCH 564
            |.||:.||.: ::...:.      .|.:|:|:|.|::|.:||.||||:.:...:...||..|:|:
 Frog   491 CYGHSNRCSY-IDFLNVV------TCVSCKHNTRGQHCQHCRLGYYRNVSAELDDENVCIECNCN 548

  Fly   565 PVGSTGKTCNHLSGQCPCKEGVTGLTCNRCARGY 598
            .:||....||. :|.|.|::|.....|:.|..||
 Frog   549 QLGSLHDRCNE-TGYCECRKGSISPKCDECLPGY 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_511155.1	LamNT	37..261	CDD:214532	63/222 (28%)
		EGF_Lam	<458..484	CDD:238012	8/40 (20%)
		EGF_Lam	498..555	CDD:238012	18/56 (32%)
		EGF_Lam	560..608	CDD:238012	14/39 (36%)
		NTR_netrin-1_like	661..791	CDD:239634
ntng2	XP_004916725.1	Laminin_N	60..283	CDD:470680	69/268 (26%)
		EGF_Lam	286..>323	CDD:238012	5/43 (12%)
		EGF_Lam	489..531	CDD:238012	17/48 (35%)
		Laminin_EGF	545..592	CDD:395007	14/38 (37%)