DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and ntn3

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_004918061.1	Gene:	ntn3 / 100486076	XenbaseID:	XB-GENE-960264	Length:	588	Species:	Xenopus tropicalis

Alignment Length:	776	Identity:	302/776 - (38%)
Similarity:	402/776 - (51%)	Gaps:	248/776 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DPCYFE-GKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYCELLRDGNAGECRSCEQQRYGPAA- 94
            ||||.| |.||:|:|.|||||:...|||||.|| :...|:|:           :.:.::..||:
Frog    39 DPCYDEHGLPRRCVPEFVNAAFNKEVQASSTCG-RLATRHCD-----------TTDPRKSYPASY 91

  Fly    95 LTDLNNPSNVTCWRSGAVNVPHDPDSAP---PDNVTLTLSLGKKYELTYISLSFCPRSPRPDSLA 156
            |||||...|:|||||         ::.|   ..||:||||||||:|:||:||.||  ||||:|:|
Frog    92 LTDLNTAGNMTCWRS---------ETFPRHSSQNVSLTLSLGKKFEVTYVSLQFC--SPRPESVA 145

  Fly   157 IFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKISKFNEQEARCINSQHD----TGGAAQRFAFNT 217
            ||||.|:|::|.|:|:|||||:|.||:|.||.::|.|||||.|.:.|.:    |||.   .||:|
Frog   146 IFKSMDYGKSWVPYQYYSSQCRKVYGKPSRASVTKQNEQEALCTDGQTELYPLTGGL---IAFST 207

  Fly   218 LEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADL 282
            |:|||||.|||:|.|||||:|||||||.|.|    |.||             |::|.:..|:.
Frog   208 LDGRPSAQDLDNSPVLQDWLTATDIRVFFSR----PHLL-------------GNKESEASDEG-- 253

  Fly   283 ELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEK 347

Frog   254 ----------------------------------------------------------------- 253

  Fly   348 HYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHAS 412
                                ||                      .:|:|.:|.||||||||||||
Frog   254 --------------------PG----------------------FYYSVGEFQVGGRCKCNGHAS 276

  Fly   413 ECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKP 477
            .|                 |:|::.                    .:.|.|||||.||||:||||
Frog   277 RC-----------------GKDKEA--------------------RLICDCKHNTEGPECDRCKP 304

  Fly   478 FYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYCRE 542
            |::||||.|||..:||||..|.||.||||||||:||||||||.|||||.||:|:|.||:||||:|
Frog   305 FHYDRPWQRATAREANECMACTCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKE 369

  Fly   543 GYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNRCARGYQQTRSHVAP 607
            |:|||.::....|:.||.|||||||:.|||||..:||||||:|||||||||||:||||:||.:||
Frog   370 GFYRDVSRAITDRRACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAKGYQQSRSPIAP 434

  Fly   608 CIK----VPTNANMIQAESAGGGGGGGTGDYKDGGGSQVEEMKKYCGKCKASPKKLNLNKFCMED 668
            |||    |||.|.....|.|                    :.::||...|.: .|:||.|:|.:|
Frog   435 CIKIPAVVPTPALTSTEEPA--------------------DCEQYCKPPKGN-YKINLKKYCKKD 478

  Fly   669 YAILAKVIGHDRASQDISTEKFSIERQNEIYKYEINIQTIFKRNPMSGTTSSLLGRGNMMLLVPR 733
            :.:...|:              .:|......|:.:||.:::|      .....:.||:..|.:..
Frog   479 FVVQVNVL--------------EMEMVGSWAKFTVNILSVYK------CRDDRIKRGDNFLWIHI 523

  Fly   734 KSIECQCPKIKLNKSYLILGRDSEA---APGYLAIGPSSVVLEWKDEWSLRMKRFQRRARK 791
            |.:.|:||||.|::.||::| .||.   .|| |....:|:|::|:|.|:.|:::.|||.:|
Frog   524 KDLSCKCPKILLSRRYLVMG-SSEGPSERPG-LTADKNSMVIQWRDAWTRRLRKLQRREKK 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	118/232 (51%)
		EGF_Lam	<458..484	CDD:238012	17/25 (68%)
		EGF_Lam	498..555	CDD:238012	39/56 (70%)
		EGF_Lam	560..608	CDD:238012	36/47 (77%)
		NTR_netrin-1_like	661..791	CDD:239634	37/132 (28%)
ntn3	XP_004918061.1	Laminin_N	52..267	CDD:395009	122/366 (33%)
		EGF_Lam	268..313	CDD:238012	31/81 (38%)
		Laminin_EGF	325..376	CDD:395007	39/50 (78%)
		Laminin_EGF	388..>425	CDD:395007	29/36 (81%)
		NTR_netrin-1_like	471..585	CDD:239634	38/134 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	105	1.000	Domainoid score	I6558
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	619	1.000	Inparanoid score	I870
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368755at33208
OrthoFinder	1	1.000	-	-		FOG0003523
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1381
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.060