Protein Alignment NetB and ntn4

DIOPT Version :10

• Sequence 1: NP_511155.1
• Gene: NetB / 32400
• FlyBaseID: FBgn0015774
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: XP_031754773.1
• Gene: ntn4 / 100379839
• XenbaseID: XB-GENE-5823493
• Length: 636
• Species: Xenopus tropicalis
• Alignment Length: 827
• Identity: 201/827 - (24%)
• Similarity: 295/827 - (35%)
• Gaps: 288/827 - (34%)

  Fly    15 IILALAIGSSAAGISS----NDPCYFEGKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYCE--- 72
            :::.|...|..||::|    ...|     .:.|.|...|.|.|..:...:.||....|..|.
 Frog    16 LLVLLGSFSLTAGLNSMVKIGSHC-----EKACNPRMGNLAIGRSLWTETTCGHNNTELSCTYQG 75

  Fly    73 -LLRDGNAGECRSCEQQRYGPAALTDLNNPSNV----------TCWRSGAVNVPHDPDSAPPDNV 126
             :.:.....:|..|.      |||..|::|.:.          |.|:| |.::..:
 Frog    76 YIEQTCTEPKCDKCN------AALPRLSHPPSAMADSSFKIPRTWWQS-AKDIHRE--------- 124

  Fly   127 TLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKISK 191
            .:.|.|..::..|::.:.|  :||||.::.:.:|.|||.||.|::::|..|...:...|     .
 Frog   125 VIRLDLETEFYFTHLIMVF--KSPRPAAMILERSQDFGVTWMPYKYFSINCSATFAMED-----D 182

  Fly   192 FNEQEARCINSQHD-----TGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLEL 251
            ..|:.|.| .|::.     |||   ...:.|:....||.| ..|...||.:..|::||
 Frog   183 IQEKGALC-TSRYSHAFPCTGG---EVIYRTMSPPYSAQD-PYSKEAQDQLKITNLRV------- 235

  Fly   252 PPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLE 316
              ||||.:
 Frog   236 --QLLKQQ--------------------------------------------------------- 241

  Fly   317 LDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSA 381
                                                   ..|.|:......|...|
 Frog   242 ---------------------------------------ACPCQEKNSDIKPQYFT--------- 258

  Fly   382 AASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANH 446
                       ||||.||.|.|.|.|||||..|||.             ||
 Frog   259 -----------HYAVYDFIVKGSCFCNGHADHCVAA-------------DG-------------- 285

  Fly   447 FGRSTQMSAKLTMT---CACKHNTAGPECERCKPFYFDRPWGRAT--DNDANECKMCQCNGHARR 506
             .|..:.::|:.:.   |.||||||||.||.|.|.|.|:.|..|.  ..:||.||.|:|||||..
 Frog   286 -FRQVRTTSKIQVVHGRCICKHNTAGPHCEHCAPLYNDQLWEAANGKTGEANTCKKCKCNGHADS 349

  Fly   507 CRFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGST-- 569
            |.|:::::..||..:||||.||||:|.|..|..|:.|::||...|.:....||.|.|||:||.
 Frog   350 CHFDMDVWLGSGNRTGGVCDNCQHNTEGSQCQRCKPGFFRDLKMPFSAPDACKACSCHPIGSAVL 414

  Fly   570 --GK--TCNHLSGQCPCKEGVTGLTCNRCARGYQQTRSH-VAPCIKVPTNANMIQAESAGGGGGG 629
              |.  .|:..:|.||||.||.|..|::|..||.....: ..||             ...|....
 Frog   415 PFGNITLCDPTNGDCPCKPGVAGPHCDQCMVGYWGFGEYGCRPC-------------DCAGSCDP 466

  Fly   630 GTGD-------------------YKDGGGSQVEEMK------KYCGKCKASPKKLNLNK-FCMED 668
            .|||                   |.:...|:..|.:      ::.|||:...:.|...: ||...
 Frog   467 FTGDCITNLDIDWYREFPELLSVYNESQLSRTWEDEQGFSALRHSGKCECKEQVLGKPEVFCGMK 531

  Fly   669 YAILAKV---IGHDRASQDISTEKFSIERQNEIYKYEI--NIQTIFKRNPMSGTTSSLLGRGNMM 728
            |:.:.||   ..||:.|.  :.....|::..::.|.:|  ..:|::   |.|.|     .||
 Frog   532 YSYVLKVKILSAHDKGSH--AEVNVKIKKVLKMSKLKILRGKRTLY---PESWT-----NRG--- 583

  Fly   729 LLVPRKSIECQCPKIKLNKSYLILGRDSEAAPGYLAIGPSSVVLEWK 775
                     |.||.:.....||:.|.: :...|.|.:...|.|..||
 Frog   584 ---------CTCPILNPGLEYLVAGYE-DIRTGRLIVNMKSFVQLWK 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_511155.1	LamNT	37..261	CDD:214532	59/242 (24%)
		EGF_Lam	<458..484	CDD:238012	15/28 (54%)
		EGF_Lam	498..555	CDD:238012	26/56 (46%)
		EGF_Lam	560..608	CDD:238012	20/54 (37%)
		NTR_netrin-1_like	661..791	CDD:239634	29/121 (24%)
ntn4	XP_031754773.1	Laminin_N	43..269	CDD:459653	70/378 (19%)
		EGF_Lam	270..322	CDD:238012	27/79 (34%)
		Laminin_EGF	341..394	CDD:395007	25/52 (48%)
		EGF_Lam	404..455	CDD:214543	20/50 (40%)
		NTR_netrin-4_like	526..634	CDD:239633	29/118 (25%)