DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and lamb3

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_012826649.2	Gene:	lamb3 / 100125073	XenbaseID:	XB-GENE-983491	Length:	1157	Species:	Xenopus tropicalis

Alignment Length:	657	Identity:	175/657 - (26%)
Similarity:	249/657 - (37%)	Gaps:	218/657 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLPIILALAIGSSAAGISSNDPCYFEGKPRKCLPSF--VNAAYGNPVQASSVCGAQQPERYCEL 73
            |:||.:|      .|....|...||         |:.  :....||.::|||.||.::||.||..
Frog     8 LVLPTLL------HAQNDCSRGACY---------PAAGDLLIGRGNYLRASSTCGIEKPETYCSP 57

  Fly    74 LRDGNAGECRSCEQQRYGPAA--LTDLNNPSNVTCW--RSGAVNVPHDPDSAPPDNVTLTLSLGK 134
            ..:.....||...:|.:...:  :|::.:|:....|  .|..:|           :|:|...|.|
Frog    58 YGEMQMKCCRCDSRQPFTEISHRITNVLSPTGHLRWWQSSNGIN-----------DVSLQFDLNK 111

  Fly   135 KYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKISKFNEQEARC 199
            |::|:.:.|.|  |||||.|:.|.:|||.|:|||.:|:.:..|...:  |...:...::.|:.||
Frog   112 KFQLSDVILDF--RSPRPASMLIERSSDHGKTWQVYQYLAYDCAASF--PHIRRGVPYDLQDVRC 172

  Fly   200 INSQHDTGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAF 264
                            ..|.|.|:...                ::.|..:||           ||
Frog   173 ----------------QELHGDPTQGG----------------KIRFSPMEL-----------AF 194

  Fly   265 SDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASD 329
            |..:..|:.                                      .:|| .|..:|.|::.
Frog   195 SVPLSHSQR--------------------------------------VQHL-ADFTNLRLNFT-- 218

  Fly   330 GESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHY 394
              .:|:                              .||.:...|||                .|
Frog   219 --QLVR------------------------------LPPRRYREPST----------------FY 235

  Fly   395 AVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTM 459
            :|....|.|.|.|.|||..|:                      ||.....:|:| ..|:..|
Frog   236 SVDVMRVHGSCFCYGHADRCM----------------------PSGALDRDHYG-DIQVYDK--- 274

  Fly   460 TCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELYKLSGRVSGGV 524
             |.|:|||.|..||||...:.|.||..|.||..|||:.|.||.||.:|.|:..:|:.||||||||
Frog   275 -CICQHNTVGENCERCADLFHDLPWRPADDNYPNECRRCNCNNHADKCHFDPAVYEASGRVSGGV 338

  Fly   525 CYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGS-TGKTCNHLSGQCPCKEGVTG 588
            |.||:..||||.|..||..|||:..|..:||..|..|||.|.|| .|.:|:.|:|:|.|||.|.|
Frog   339 CDNCRDGTTGRNCERCRSDYYRNPNKDMSHRDACISCDCDPEGSIDGGSCDDLTGRCNCKENVGG 403

  Fly   589 LTCNRCARGYQ-QTRSHVAPCIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQVEEMKKYCGKC 652
            ..|::|..||. .:.|:...|.|...|..                     |..:.:......|:|
Frog   404 ERCDQCKPGYYLLSASNPQGCTKCTCNPQ---------------------GMERDQPCDSETGQC 447

  Fly   653 KASPKKL 659
            |..|..|
Frog   448 KCLPNVL 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	54/229 (24%)
		EGF_Lam	<458..484	CDD:238012	11/25 (44%)
		EGF_Lam	498..555	CDD:238012	30/56 (54%)
		EGF_Lam	560..608	CDD:238012	21/49 (43%)
		NTR_netrin-1_like	661..791	CDD:239634
lamb3	XP_012826649.2	Laminin_N	26..244	CDD:395009	73/373 (20%)
		EGF_Lam	245..302	CDD:238012	25/83 (30%)
		EGF_Lam	311..369	CDD:238012	30/57 (53%)
		Laminin_EGF	375..424	CDD:395007	21/48 (44%)
		Laminin_EGF	427..474	CDD:395007	7/49 (14%)
		Laminin_EGF	477..525	CDD:395007
		EGF_Lam	525..569	CDD:214543
		Smc	<815..1149	CDD:224117
		cc_LAMB_C	1087..1157	CDD:424069
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910