Protein Alignment APC and Apc

DIOPT Version :10

• Sequence 1: NP_001394375.1
• Gene: APC / 324
• HGNCID: 583
• Length: 2871
• Species: Homo sapiens
• Sequence 2: NP_477152.1
• Gene: Apc / 44642
• FlyBaseID: FBgn0015589
• Length: 2417
• Species: Drosophila melanogaster
• Alignment Length: 3039
• Identity: 756/3039 - (24%)
• Similarity: 1113/3039 - (36%)
• Gaps: 1036/3039 - (34%)

Human    77 DLLERLKELNLDSSNFPGVKLRSKMSL-----------RSYGSREG------SVSSRSGECSPVP 124
            ||.|.:.||:|:..:...|..|....|           ..:|:..|      ....|.||.|...
  Fly     9 DLEEGIAELSLEDVDVDSVPERKPHFLDYDAVPPPDYEEGFGASSGEQLKMDKKYERDGEVSDYE 73

Human   125 MGS--FPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTEN 187
            :.:  :.::.|.    :....|...:....|....:.|:...|.:           :|..|:..:
  Fly    74 LAASGYTKKEFT----QDDNTLHFTQSAVGLGSGAVGKKPAAKHF-----------LDENPIPPD 123

Human   188 FSLQTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEA 252
            :.|            |:::|...|.     :.:::..:|:.|:.||:  |.|..|....|.|: |
  Fly   124 YML------------AQELREMREH-----RSLDRNFERQSAQQQQL--DELPPRNGGGSPAS-A 168

Human   253 ERSSQNKHETGSHDAERQNEGQGVGEINMATSGNGQGSTTRMDHE-TASVLSSSSTHSAPRRLTS 316
            .|.|::|..  |:...|..:|..........  .|...||..|.. |:|.:.::
  Fly   169 GRPSRSKEP--SYTLSRFLDGDAPAPAPRLP--KGAAWTTSFDERYTSSAVEAT----------- 218

Human   317 HLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLLHGNDKDSVLLG 381
             ||:|||.|||||||||::|..:|::..|.:|.:..||.::|:|||:|||:|::|..|.|
  Fly   219 -LGSKVECVYSLLSMLGSNDPLEMAKKFLELSGNAQSCATLRRSGCMPLLVQMMHAPDND----- 277

Human   382 NSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGM--DQD 444
                 :|.|..|..||||::||.||:|.||||.:||.||:||..||.......::....:  |.|
  Fly   278 -----QEVRKCAGQALHNVVHSHPDEKAGRREAKVLRLLDQIVDYCSFLKTLLQSGGEAIADDSD 337

Human   445 KNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGRKATRGISSQELGQGLSGGLQAIAELLQV 509
            ::|:         .|:..|||:||||||||||.||                  |.|.||..|:.:
  Fly   338 RHPL---------AAISSLMKVSFDEEHRHAMCEL------------------GALHAIPNLVHL 375

Human   510 DCEMYG-LTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIA 573
            |..::| ...|....:|||||.||||||||||..|||.||..|..|.||||||.|..:||.||.|
  Fly   376 DHAVHGPKPEDQCCNSLRRYALMALTNLTFGDENNKALLCGQKQFMEALVAQLDSAPDDLLQVTA 440

Human   574 SVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVD 638
            |||||||||||.|.|..|.|:|:|.||...|:..:.|:|||::|||||||||||:.|||:.||||
  Fly   441 SVLRNLSWRADSNMKAVLNEIGTVTALALAAMRNRSENTLKAILSALWNLSAHCSTNKAEFCAVD 505

Human   639 GALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLT 703
            ||||||||.|:|...:.||.|||:.|||||||||.||..|.:|||||::|||..|||.|||.|||
  Fly   506 GALAFLVGMLSYEGPSKTLKIIENAGGILRNVSSHIAVCEPYRQILRQHNCLAILLQQLKSESLT 570

Human   704 IVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYK-- 766
            :|||:||||||||||:.:||:.|||.|||.||::||||||.||:.||::||:||:..|||...
  Fly   571 VVSNSCGTLWNLSARSAEDQKFLWDNGAVPMLRSLIHSKHAMISEGSSSALKNLLNFRPAVQNHH 635

Human   767 --DANIMSPG-SSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYV 828
              |....|.| .:||:|..||.|||:.||..:|.:||.||:|
  Fly   636 QLDPIARSMGLKALPTLEARKAKALQQELGERHTAETCDNLD----------------------- 677

Human   829 FDTNRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGSLDSSRSEKDRSLERERGIGLGNYHP 893
                           ||                     |.||           :||.......||
  Fly   678 ---------------TG---------------------GKLD-----------KERASSSSRRHP 695

Human   894 ATENPGTSSKRGLQISTTAAQIAKVMEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHT 958
                              |.::.:     ||:.|..|.|.|..:.:..|..|.
  Fly   696 ------------------APRLTR-----SAMLTKSESRDSVYSAKSDCAYDH------------ 725

Human   959 HSNTYNFTKSENSNRTCSMPYAKLEYKRSSNDSLNSVSSSDGYGKRGQMKPSIESYSEDDESKFC 1023
                                            .:.|.|:||.:.|   :||.|..:..:.|
  Fly   726 --------------------------------LIRSASASDAHRK---VKPKITDFDLEME---- 751

Human  1024 SYGQYPADLAHKIHSANHMDDNDGELDTPINYSLKYSDEQLNSGRQSPSQNERWARPKHIIEDEI 1088
                               .|.:...:.||:||:|||
  Fly   752 -------------------QDTEATEEQPIDYSVKYS---------------------------- 769

Human  1089 KQSEQRQSRNQSTTYPVYTESTDDKHLKFQPHFGQQECVSPYRSRGANGSETNRVGSNHGINQNV 1153
                  ::..:::||
  Fly   770 ------ENATKTSTY-------------------------------------------------- 778

Human  1154 SQSLCQEDDYEDDKPTNYSERYSEEEQHEEEERPTNYSIKYNEEKRHVDQPIDYSLKYATDIP-S 1217
                 ||.|.  |:||::|.||:|    .:.|...:.|.....:|..:..|       |..:| .
  Fly   779 -----QETDL--DQPTDFSLRYAE----NQIESDLDISGPAGGQKSTITPP-------AETVPEK 825

Human  1218 SQKQSFSFSKSSSGQSSKTEH-----MSSSSENTSTPSSNAKRQNQLHPS--SAQSRSGQPQ--- 1272
            |:.|........|.:..:||.     .:::|......::.|..:.::.|.  ...|:.|.|:
  Fly   826 SEGQEILLILDDSVKCYQTEDTPYVISNAASVTDLRVAAKADAEAEVKPEVREVTSKEGAPKKLP 890

Human  1273 KAATCKVSSINQETIQTYCVEDTPICFSRCSSLSSLSSAEDEIG-CNQTTQEADSANTLQIAEIK 1336
            |.:.|...|...|....||.|.||..|||..|||||    ||.| .||.....|       |:||
  Fly   891 KLSQCGSGSYTPEKPINYCEEGTPGYFSRYDSLSSL----DESGKANQAIVGTD-------ADIK 944

Human  1337 EKIGTRSAEDPVSEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQTPKSPP 1401
            .|:..:..::.......:::.|...:|.|
  Fly   945 PKLEKQEEQESQPAEQVLTKPPTQANSAL------------------------------------ 973

Human  1402 EHYVQETPLMFSRCTSVSSLDSFESRSIA-----SSVQSEPCSGMVSGIISPSDLPDSPGQTMPP 1461
                 ||||||||.:|:.||.......:|     |||.|: .|.:.||:||||::||||.|:||.
  Fly   974 -----ETPLMFSRRSSMDSLVHDPDVDVANCDDKSSVVSD-FSRLASGVISPSEIPDSPTQSMPQ 1032

Human  1462 SRSKTPPPPPQTAQTKREVPKNKAPTAEKRESGPKQAAVNAAVQRVQVLPDADTLLHFATESTPD 1526
            |..:                .:.|.:.:..:|.|  ..:.|::|.::.:.: |.|..|..|.||.
  Fly  1033 SPRR----------------NSVAGSGQNVDSPP--VVIPASLQPLRSVFE-DDLSSFNVEHTPA 1078

Human  1527 GFSCSSSLSALSL--DEPFIQKDVELRIMPPVQENDNGNE-------------TESEQPKESNEN 1576
            .||.::|||.||:  ||         :....|.|.||.:|             ..:|..|.:..|
  Fly  1079 QFSTATSLSNLSIVDDE---------KAPASVAEEDNEDELLLANCINMGMQRKPTEAVKSTVVN 1134

Human  1577 QEKE-AEKTIDS----------------------------EKD------------LLDD--SDDD 1598
            .|.: ||:||.|                            .||            |.||  |:..
  Fly  1135 SEVDVAEETIRSYCTEDTPALLSKVPSNTNLSVISMSSTDPKDATAGQAQMYAHQLSDDVSSNAS 1199

Human  1599 DI-----EILEECIISAMPTKSSRKAKKPAQTASKLPPPVARK-PSQLPVYKLLPSQNRLQPQKH 1657
            |.     .:|::||...|        |||...|:..|..:.|: .::||.|  |||
  Fly  1200 DCGGASGHLLQQCIRDGM--------KKPLGEATSDPIAMLRRGGNELPGY--LPS--------- 1245

Human  1658 VSFTPGDDMPRVYCVEGTPINFSTATSLSDLTIES----PPNELAAGEGVRGGAQSGEFEKRDTI 1718
                 .|:|.: :.||.:|.|||..:.||:||:.|    |..:|...| .....|:.|.:.:...
  Fly  1246 -----ADEMNK-FLVEDSPCNFSVVSGLSNLTVGSSLVGPAVQLKETE-PSSADQNPEMKAKPGK 1303

Human  1719 PTEGRSTDEAQGGKTSSVTIPELDDNKAEEGDILAEC--------------------------IN 1757
            ..:.|.....|....||::|...||.......|.|.|                          ||
  Fly  1304 QEQVRRPPHWQDDSLSSLSIDSEDDTNLLSQAIAAGCNRPKSNLGFSSNGKRSSSLSSSQPIAIN 1368

Human  1758 SAMPKGKSHKPFRVKKIMDQVQQASASSSAPNKNQ---------LDG--KKKKP----------- 1800
            :|......:....|:|...|...:|..||..|.||         |.|  |.|:|
  Fly  1369 AATSASSLNSAMTVRKSQQQESYSSVDSSDSNDNQSKSLFELCILKGMYKTKEPGARAQQMQEQP 1433

Human  1801 ---TSPVKPIPQNTEYRT------------RVRKNADSKNNLNAERVFSDNKDSK-KQNLKNN-- 1847
               :|.|:..|...::.:            |.|.:....::...||   :.||.| .|...|.
  Fly  1434 IVGSSSVQSNPSLKQFDSLPVQLPSSGQVKRQRHHHHHHHHRERER---ERKDEKLLQECINTGI 1495

Human  1848 SKVFNDKLPNNEDRVRGSFAFDSPHHYTPIEGTPYCFSRNDSLSSLDFDDDDVDLSREKAELRKA 1912
            ||..| .:|.|.  :..|.|...|.|  |:..|       .|.|:|.....||
  Fly  1496 SKKIN-AVPKNV--LATSAAALEPCH--PMAAT-------TSASALSTAAPDV------------ 1536

Human  1913 KENKESEAKVTSHTELTSNQQSANKTQAIAKQPI----------------NRGQPKPILQKQSTF 1961
                |.:|..||:.:   .|.|.:.:..|...||                |:|..........|
  Fly  1537 ----EQKAHATSNPQ---QQSSTHPSSHILPNPIDAIATVTDTVRSPAAPNQGNGNASQNGLET- 1593

Human  1962 PQSSKDIPDRGAATDEKLQNFAIEN--------TPVCF--------------------------- 1991
            ...|||:.....::||..|:|.:|.        ...|.
  Fly  1594 ATGSKDLDSEDRSSDESNQSFIMETMVRLDSALNETCISGASEKHKDPDLMLKSVERLTMEFVTS 1658

Human  1992 -------SHNSSLSSLSDIDQENNNKENEPIKETEPPDSQGEPSKPQASGYAPKSFHVEDTPVCF 2049
                   |||.|.|     :...||..|....|:..|:....||..|.:            ||
  Fly  1659 AEQLRSSSHNHSSS-----NSHKNNSSNNTWNESTCPNDVSFPSVSQTA------------PV-- 1704

Human  2050 SRNSSLSSLSID---SEDDLLQECISSAMPKKKKPSRLKGDNEK----HSPRNMGGILGEDLTLD 2107
                 |:|||:|   :|...|.|.|......:::|..|:|:.:.    |:....|...|.:..|.
  Fly  1705 -----LASLSLDEDATEARSLHELIEITPTNEQQPESLEGETDTLVNGHADSYSGSSGGLNFQLG 1764

Human  2108 LKDIQRPDSEHGLSPDSENFDWKAIQEGANSIVSSLHQAAAAACLSRQASSDSD------SILSL 2166
             ..:|.....  |.|....|:..:.....||.:.:....|.|..|.:.|::|.|      |:.||
  Fly  1765 -GQVQNAGVR--LEPQRLLFNGTSASIMTNSTMIAFEARALAENLLQPAATDDDTTEMTFSLNSL 1826

Human  2167 -------KSGI-SLGSPF--HLTPDQEEKPFTSNKGPRILKPGEKSTLETKKIESESKGIKGGKK 2221
                   .||: ||.|.:  |..|....:...| |.||..:....:.|..::......|
  Fly  1827 DLDNIRPPSGMESLNSCYQDHSQPSSLRQAMPS-KSPRFARKMFPANLVARRALGHLAG------ 1884

Human  2222 VYKSLITGKVRSNSEISGQMKQPLQANMPSISRGRTMIHIPGVRN---------SSSSTSPVSKK 2277
                 ....|.|:..:...:|.|  :.|..:.  .:||.:..:::         |.::|..||..
  Fly  1885 -----SAESVNSSCNLLDNIKPP--SLMDELL--DSMISVDSIQSEVADGEQDCSMATTISVSNY 1940

Human  2278 GPPL-----------------------KTPASKSPSEGQTATTSPRGAKPSVKSEL--------- 2310
            ....                       .:.|..:|..|.|.:.:.|...|..|..|
  Fly  1941 ETAACDDQTMTVLQSCFDEDEDATMNDYSSAESTPKHGSTPSPNRRSLTPKDKRRLTKDRFKTYT 2005

Human  2311 --------SPVARQTSQI-------GGSSKAPSRSGSRDSTPSRPAQQPLSRPI----------- 2349
                    :|.|.:|.||       ..::.:|..:|.|..:..|...|.:..|:
  Fly  2006 IATSCEMEAPEANETLQIEIVEAAVPVATPSPRANGRRRGSAERYKTQLIECPLALIQPQPDDCP 2070

Human  2350 ---------------------------------------QSP--GRNSISPGRNG-----ISPPN 2368
                                                   :||  .:||.:...:|     :.||.
  Fly  2071 SEQLSSIRAMMQQFTFITDINIGHSQETCESTDHPEDAGESPECDQNSETESCDGQEPDQLPPPP 2135

Human  2369 KLSQL------PRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASK 2427
            .:..|      |.|..|:||.....|..|.:|.||....||:|       |.||:
  Fly  2136 SIVDLRTSVVKPTTLEPATAVKLVRGRKKPAYVSPYSMQSQRN-------SNNAA---------- 2183

Human  2428 GLNQMNNGNGANKKVELSRMSSTKS-----SGSESDRSERPV---------LVRQSTFIKEAPSP 2478
                      .:||..||...:.:|     ||......::|.         |.||.||:|:
  Fly  2184 ----------PSKKKTLSPTIAKRSLVPGGSGVRLPAKKKPTPPPEPAPARLERQGTFVKD---- 2234

Human  2479 TLRRKLEESASFESLSPSSRPASPTRSQAQTPVLSPSLPDMSLSTHSSVQAGGWRKLPPNLSPTI 2543
                                  .||.|..|.||:. :.|..:..||.:      .|||......
  Fly  2235 ----------------------EPTNSNVQVPVVE-TKPAQTSPTHRA------SKLPTKKGTA- 2269

Human  2544 EYNDGRPAKRHDIARSHSESPSRLPINRSGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSES 2608
              :.|.|:|        :.||.|:|:..:   :|...:.:::..|::..:...:|..:....|.:
  Fly  2270 --SGGSPSK--------AGSPKRIPLAPA---RRMTPQRANTSLRLAAGKSHAASRVVSGRVSST 2321

Human  2609 SEKAKSEDEKHVNSISGTKQSKENQVSAK--GTWRKIKENEFSPTNS---TSQTVSSGATNGAES 2668
            :..::|....:.:|.:....:|.|...::  ..|:::.|.:...::|   |.:|.||...|...:
  Fly  2322 TPPSRSNSNLNGSSAAAAAAAKINHAQSRIANIWKRVDEAKTKQSSSNLRTQKTKSSNMLNANGT 2386

Human  2669 KTLIYQMAPAVSKTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEK 2717
            |..:.:     |.|.|                     |||.....|..|
  Fly  2387 KPTLLR-----SSTFD---------------------NTPSTAGGVKSK 2409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APC	NP_001394375.1	Suppressor_APC	137..217	CDD:463275	10/79 (13%)
		ARM	350..402	CDD:214547	20/51 (39%)
		APC_rep	403..476	CDD:465870	31/74 (42%)
		armadillo repeat	500..536	CDD:293788	16/36 (44%)
		ARM	540..581	CDD:214547	26/40 (65%)
		armadillo repeat	544..581	CDD:293788	24/36 (67%)
		armadillo repeat	591..623	CDD:293788	16/31 (52%)
		armadillo repeat	631..672	CDD:293788	28/40 (70%)
		ARM	677..717	CDD:214547	28/39 (72%)
		armadillo repeat	681..715	CDD:293788	25/33 (76%)
		Arm	719..759	CDD:425727	24/39 (62%)
		armadillo repeat	723..759	CDD:293788	23/35 (66%)
		Arm_APC_u3	760..1047	CDD:435476	50/291 (17%)
		APC_u5	1064..1163	CDD:406923	4/98 (4%)
		APC_r	1285..>1302	CDD:461781	8/16 (50%)
		APC_u9	1311..1396	CDD:435478	13/85 (15%)
		PTZ00449	<1319..1729	CDD:185628	116/482 (24%)
		APC_r	1665..1688	CDD:461781	9/22 (41%)
		APC_u13	1690..1743	CDD:406927	11/56 (20%)
		SAMP	1744..1765	CDD:461782	6/46 (13%)
		APC_u14	1774..1867	CDD:435479	30/132 (23%)
		APC_u15	1901..1975	CDD:435480	15/89 (17%)
		SAMP	2061..2080	CDD:461782	5/21 (24%)
		APC_basic	2251..2596	CDD:428690	84/477 (18%)
		EB1_binding	2698..2871	CDD:399141	5/20 (25%)
Apc	NP_477152.1	ARM	251..293	CDD:214547	20/51 (39%)
		armadillo repeat	258..332	CDD:293788	35/83 (42%)
		APC_rep	294..360	CDD:465870	31/74 (42%)
		armadillo repeat	369..403	CDD:293788	14/33 (42%)
		armadillo repeat	411..448	CDD:293788	24/36 (67%)
		armadillo repeat	498..539	CDD:293788	28/40 (70%)
		Arm	544..584	CDD:425727	28/39 (72%)
		armadillo repeat	548..582	CDD:293788	25/33 (76%)
		armadillo repeat	590..624	CDD:293788	21/33 (64%)
		APC_15aa	757..771	CDD:461790	7/47 (15%)
		APC_r	903..926	CDD:461781	12/22 (55%)
		APC_r	1066..1089	CDD:461781	11/22 (50%)
		APC_r	1247..1270	CDD:461781	10/23 (43%)
		Herpes_BLLF1	<2239..>2413	CDD:282904	42/218 (19%)