Protein Alignment NetA and NTN1

DIOPT Version :10

• Sequence 1: NP_511154.3
• Gene: NetA / 32398
• FlyBaseID: FBgn0015773
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_004813.2
• Gene: NTN1 / 9423
• HGNCID: 8029
• Length: 604
• Species: Homo sapiens
• Alignment Length: 728
• Identity: 317/728 - (43%)
• Similarity: 411/728 - (56%)
• Gaps: 161/728 - (22%)

  Fly     9 LLGTTRFSPIQCISNDVYFKMFSQQAPPEDPCYNKAHEPRACIPDFVNAAYDAPVVASSTCGSSG 73
            |:|..|..|        ...||:.||...|||.::...||.|||||||||:...|..|||||...
Human    18 LVGAVRGGP--------GLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPP 74

  Fly    74 AQRYC----EYQDHERSCHTCDMTDPLRSFPARSLTDLNNSNNVTCWRSEPVTGSGDNVTLTLSL 134
            | |||    ..::..||||.|:.:||.::.|...||||||.:|:|||:||.......||||||||
Human    75 A-RYCVVSERGEERLRSCHLCNASDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSL 138

  Fly   135 GKKFELTYVILQLCPHAPRPDSMVIYKSTDHGLSWQPFQFFSSQCRRLFGRPARQSTGRHNEHEA 199
            |||||:|||.||.|  :|||:||.||||.|:|.:|.||||:|:|||:::.||.|....:.||.||
Human   139 GKKFEVTYVSLQFC--SPRPESMAIYKSMDYGRTWVPFQFYSTQCRKMYNRPHRAPITKQNEQEA 201

  Fly   200 RCSDV---TRPLV-SRIAFSTLEGRPSSRDLDSSPVLQDWVTATDIRVVFHRLQRPDPQALLSLE 260
            .|:|.   .|||. ..||||||:||||:.|.|:|||||||||||||||.|.||.      ....|
Human   202 VCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLH------TFGDE 260

  Fly   261 AGGATDLASGKYSVPLANGPAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTD 325
            ....::||...|                            .||:||..|||||||||||::|..|
Human   261 NEDDSELARDSY----------------------------FYAVSDLQVGGRCKCNGHAARCVRD 297

  Fly   326 ASGQLNCECSHNTAGRDCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQG 390
            ....|.|:|.|||||.:|:||||||:||||.||||:|||||..||||.|||:||||||:::||..
Human   298 RDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGR 362

  Fly   391 VSGGVCQNCRHSTTGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKD 455
            .|||||.||||:|.||:||.||||:|||..||:||||.||||||||:|::||.||.|:|||||||
Human   363 KSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKD 427

  Fly   456 GVTGLTCNRCARGYQQSRSHIAPCIKQPPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGMAA 520
            ||||:||||||:|||||||.||||||.|     :......|...:|||
Human   428 GVTGITCNRCAKGYQQSRSPIAPCIKIP-----VAPPTTAASSVEEPE----------------- 470

  Fly   521 QSQYYRTEGGRECGK-CRVSTKRL--NLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDV 582
                       :|.. |:.|..:|  |:.|:||:|||:...::..|
Human   471 -----------DCDSYCKASKGKLKINMKKYCKKDYAVQIHILKAD------------------- 505

  Fly   583 ADYEMDQVQPGSARSPITGVYEFQAADYPNPNPNPRGSEMERFDLQIQAVFKRSRPGESSGAGNV 647
                                   :|.|:            .:|.:.|.:|:|:.
Human   506 -----------------------KAGDW------------WKFTVNIISVYKQG----------- 524

  Fly   648 YGMPNTTLKRGPMTWIIPTKDLECRCPRIRVNRSYLILGRDSEAPPGYLGI--GPHSIVIEWKED 710
                .:.::||..:..|.::|:.|:||:|:..:.||:|| ::|..|...||  ...|:||:|::.
Human   525 ----TSRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLG-NAEDSPDQSGIVADKSSLVIQWRDT 584

  Fly   711 WYRRMKRFQRRAR 723
            |.||:::||:|.:
Human   585 WARRLRKFQQREK 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_511154.3	LamNT	44..280	CDD:214532	126/243 (52%)
		EGF_Lam	312..357	CDD:238012	29/44 (66%)
		EGF_Lam	369..426	CDD:238012	39/56 (70%)
		EGF_Lam	431..479	CDD:238012	38/47 (81%)
		NTR_netrin-1_like	545..723	CDD:239634	39/179 (22%)
NTN1	NP_004813.2	LamNT	46..283	CDD:214532	131/273 (48%)
		EGF_Lam	284..329	CDD:238012	29/44 (66%)
		Laminin_EGF	341..401	CDD:395007	42/59 (71%)
		Laminin_EGF	404..>441	CDD:395007	28/36 (78%)
		NTR_netrin-1_like	487..601	CDD:239634	39/181 (22%)
		Cell attachment site. /evidence=ECO:0000255	530..532		1/1 (100%)