DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetA and ntn1

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001072385.1	Gene:	ntn1 / 779839	XenbaseID:	XB-GENE-989335	Length:	601	Species:	Xenopus tropicalis

Alignment Length:	699	Identity:	266/699 - (38%)
Similarity:	362/699 - (51%)	Gaps:	153/699 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PEDPCYNKAHEPRACIPDFVNAAYDAPVVASSTCGSSGAQRYCEYQDH----ERSCHTCDMTDPL 96
            |:.|||:....|:.|||||:|.|....|:.|:|||.: .|:.|.:.|.    .|.|..||...|.
Frog    38 PDGPCYDAKQRPKYCIPDFINVALGQEVITSNTCGRT-PQKLCYFLDSTNVTSRRCQLCDQKRPE 101

  Fly    97 RSFPARSLTDLNNSNNVTCWRSEPVTGSGDNVTLTLSLGKKFELTYVILQLCPHAPRPDSMVIYK 161
            .|:|...:||   ::..|||:||.......||||||.||::|||.|..|:.|  :||||||.|||
Frog   102 NSYPPSYMTD---TDAQTCWKSESGITFPQNVTLTLPLGRRFELVYASLRFC--SPRPDSMAIYK 161

  Fly   162 STDHGLSWQPFQFFSSQCRRLFGRPARQSTGRHNEHEARCSDV---TRPLV-SRIAFSTLEGRPS 222
            |.|:|.:|.||||:|:.|||::.:....:..:..:|||.|:|.   .:||. ..:||..|.||||
Frog   162 SMDYGKTWIPFQFYSTHCRRVYDQATTSAISKPMQHEATCTDFQTGVKPLTKGLVAFMPLAGRPS 226

  Fly   223 SRDLDSSPVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLASGKYSVPLANGPAGNNIEA 287
            :|..:.|||||||||||||||||:||..
Frog   227 ARRFEYSPVLQDWVTATDIRVVFNRLHH------------------------------------- 254

  Fly   288 NLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTDASGQLNCECSHNTAGRDCERCKPFHFD 352
              |..:........|.:|:..||||||||||||:|:....| |.|||.|||.|.:|:.||||::|
Frog   255 --GKKMGIRRKTAFYGVSEIQVGGRCKCNGHASRCTAGKEG-LMCECQHNTIGPECDACKPFYYD 316

  Fly   353 RPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNCRHSTTGRNCHQCKEGFYR 417
            |||.|||...|:||..|.||.|:.:||||||:::||...|||||.||||:|.||:||.||:|:.|
Frog   317 RPWQRATPSNAHECVACECNLHSHRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKQGYKR 381

  Fly   418 DATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKDGVTGLTCNRCARGYQQSRSHIAPCIKQ 482
            |.:||:|.||.||.|.|||||:...:||.|:|||.||.||||.||||||.|||||||...||::.
Frog   382 DLSKPITSRKACKPCQCHPIGAVNAMCNQTTGQCQCKTGVTGPTCNRCAPGYQQSRSAHMPCVRI 446

  Fly   483 PPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGMAAQSQYYRTEGGRECGKCRVSTKR--LNL 545
            ...|      ..||..|.|.::         |..|...||.            |:.|..|  :||
Frog   447 QEEM------TTTASYPQEWKA---------GTNGTECQSY------------CKPSHSRVHMNL 484

  Fly   546 NKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVADYEMDQVQPGSARSPITGVYEFQAADY 610
            .|:||:||.:.|:::..:.|.|                                  .::|.|.
Frog   485 RKYCKKDYVLRAQLLSMEKSGE----------------------------------WWQFTAT-- 513

  Fly   611 PNPNPNPRGSEMERFDLQIQAVFKRSRPGESSGAGNVYGMPNTTLKRGPMTWIIPTKDLECRCPR 675
                              :..|:::.|               ..::||.....:|..||.|.|.|
Frog   514 ------------------VLTVYRQRR---------------VPIRRGDQPLWVPDHDLACDCLR 545

  Fly   676 IRVNRSYLILGRDSEAP-PGYLGIGPHSIVIEWKEDWYRRMKRFQRRAR 723
            ::|.:||||:|.|.|:| |..|.:..:|:.:.|::.|..:::|||::.|
Frog   546 VQVGKSYLIIGNDEESPDPARLILDKNSLALPWRDVWGHKLRRFQQQER 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	99/243 (41%)
		EGF_Lam	312..357	CDD:238012	28/44 (64%)
		EGF_Lam	369..426	CDD:238012	34/56 (61%)
		EGF_Lam	431..479	CDD:238012	31/47 (66%)
		NTR_netrin-1_like	545..723	CDD:239634	38/178 (21%)
ntn1	NP_001072385.1	Laminin_N	61..276	CDD:365840	95/259 (37%)
		EGF_Lam	277..321	CDD:238012	28/44 (64%)
		EGF_CA	333..386	CDD:389777	31/52 (60%)
		EGF_Lam	395..444	CDD:238012	32/48 (67%)
		NTR_netrin-1_like	484..598	CDD:239634	39/180 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I2507
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	619	1.000	Inparanoid score	I870
OMA	1	1.010	-	-		QHG48023
OrthoDB	1	1.010	-	-		D368755at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48313
Panther	1	1.100	-	-	LDO	PTHR10574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1381
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.080