Protein Alignment NetA and ntn5

DIOPT Version :10

• Sequence 1: NP_511154.3
• Gene: NetA / 32398
• FlyBaseID: FBgn0015773
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_001072385.1
• Gene: ntn5 / 779839
• XenbaseID: XB-GENE-22063027
• Length: 601
• Species: Xenopus tropicalis
• Alignment Length: 699
• Identity: 266/699 - (38%)
• Similarity: 362/699 - (51%)
• Gaps: 153/699 - (21%)

  Fly    36 PEDPCYNKAHEPRACIPDFVNAAYDAPVVASSTCGSSGAQRYCEYQDH----ERSCHTCDMTDPL 96
            |:.|||:....|:.|||||:|.|....|:.|:|||.: .|:.|.:.|.    .|.|..||...|.
 Frog    38 PDGPCYDAKQRPKYCIPDFINVALGQEVITSNTCGRT-PQKLCYFLDSTNVTSRRCQLCDQKRPE 101

  Fly    97 RSFPARSLTDLNNSNNVTCWRSEPVTGSGDNVTLTLSLGKKFELTYVILQLCPHAPRPDSMVIYK 161
            .|:|...:||   ::..|||:||.......||||||.||::|||.|..|:.|  :||||||.|||
 Frog   102 NSYPPSYMTD---TDAQTCWKSESGITFPQNVTLTLPLGRRFELVYASLRFC--SPRPDSMAIYK 161

  Fly   162 STDHGLSWQPFQFFSSQCRRLFGRPARQSTGRHNEHEARCSDV---TRPLV-SRIAFSTLEGRPS 222
            |.|:|.:|.||||:|:.|||::.:....:..:..:|||.|:|.   .:||. ..:||..|.||||
 Frog   162 SMDYGKTWIPFQFYSTHCRRVYDQATTSAISKPMQHEATCTDFQTGVKPLTKGLVAFMPLAGRPS 226

  Fly   223 SRDLDSSPVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLASGKYSVPLANGPAGNNIEA 287
            :|..:.|||||||||||||||||:||..
 Frog   227 ARRFEYSPVLQDWVTATDIRVVFNRLHH------------------------------------- 254

  Fly   288 NLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTDASGQLNCECSHNTAGRDCERCKPFHFD 352
              |..:........|.:|:..||||||||||||:|:....| |.|||.|||.|.:|:.||||::|
 Frog   255 --GKKMGIRRKTAFYGVSEIQVGGRCKCNGHASRCTAGKEG-LMCECQHNTIGPECDACKPFYYD 316

  Fly   353 RPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNCRHSTTGRNCHQCKEGFYR 417
            |||.|||...|:||..|.||.|:.:||||||:::||...|||||.||||:|.||:||.||:|:.|
 Frog   317 RPWQRATPSNAHECVACECNLHSHRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKQGYKR 381

  Fly   418 DATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKDGVTGLTCNRCARGYQQSRSHIAPCIKQ 482
            |.:||:|.||.||.|.|||||:...:||.|:|||.||.||||.||||||.|||||||...||::.
 Frog   382 DLSKPITSRKACKPCQCHPIGAVNAMCNQTTGQCQCKTGVTGPTCNRCAPGYQQSRSAHMPCVRI 446

  Fly   483 PPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGMAAQSQYYRTEGGRECGKCRVSTKR--LNL 545
            ...|      ..||..|.|.::         |..|...||.            |:.|..|  :||
 Frog   447 QEEM------TTTASYPQEWKA---------GTNGTECQSY------------CKPSHSRVHMNL 484

  Fly   546 NKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVADYEMDQVQPGSARSPITGVYEFQAADY 610
            .|:||:||.:.|:::..:.|.|                                  .::|.|.
 Frog   485 RKYCKKDYVLRAQLLSMEKSGE----------------------------------WWQFTAT-- 513

  Fly   611 PNPNPNPRGSEMERFDLQIQAVFKRSRPGESSGAGNVYGMPNTTLKRGPMTWIIPTKDLECRCPR 675
                              :..|:::.|               ..::||.....:|..||.|.|.|
 Frog   514 ------------------VLTVYRQRR---------------VPIRRGDQPLWVPDHDLACDCLR 545

  Fly   676 IRVNRSYLILGRDSEAP-PGYLGIGPHSIVIEWKEDWYRRMKRFQRRAR 723
            ::|.:||||:|.|.|:| |..|.:..:|:.:.|::.|..:::|||::.|
 Frog   546 VQVGKSYLIIGNDEESPDPARLILDKNSLALPWRDVWGHKLRRFQQQER 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_511154.3	LamNT	44..280	CDD:214532	99/243 (41%)
		EGF_Lam	312..357	CDD:238012	28/44 (64%)
		EGF_Lam	369..426	CDD:238012	34/56 (61%)
		EGF_Lam	431..479	CDD:238012	31/47 (66%)
		NTR_netrin-1_like	545..723	CDD:239634	38/178 (21%)
ntn5	NP_001072385.1	Laminin_N	48..276	CDD:470680	103/272 (38%)
		EGF_Lam	277..321	CDD:238012	28/44 (64%)
		Laminin_EGF	333..393	CDD:395007	36/59 (61%)
		EGF_Lam	395..444	CDD:238012	32/48 (67%)
		NTR_netrin-1_like	484..598	CDD:239634	39/180 (22%)