Protein Alignment NetA and ntn2

DIOPT Version :10

• Sequence 1: NP_511154.3
• Gene: NetA / 32398
• FlyBaseID: FBgn0015773
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_001032492.2
• Gene: ntn2 / 641469
• ZFINID: ZDB-GENE-050310-2
• Length: 609
• Species: Danio rerio
• Alignment Length: 704
• Identity: 315/704 - (44%)
• Similarity: 408/704 - (57%)
• Gaps: 142/704 - (20%)

  Fly    33 QAPPEDPCYNKAHEPRACIPDFVNAAYDAPVVASSTCGSSGAQRYCEYQDHE-----RSCHTCDM 92
            |..|.||||.:....|.|||:|:|||:...|..||.||.. ..|.|...:.:     |:|..||.
Zfish    28 QVTPTDPCYEETGAARRCIPEFINAAFGQEVSVSSVCGRP-VSRSCSLVERDDRPAVRTCQICDA 91

  Fly    93 TDPLRSFPARSLTDLNNSNNVTCWRSEPVTGSGDNVTLTLSLGKKFELTYVILQLCPHAPRPDSM 157
            :||..:.||..|||||:::|:|||:||.:..|..|||||||||||||:|||.||.|  :|||:|:
Zfish    92 SDPRNAHPASYLTDLNSAHNLTCWQSENLQSSPLNVTLTLSLGKKFEITYVSLQFC--SPRPESL 154

  Fly   158 VIYKSTDHGLSWQPFQFFSSQCRRLFGRPARQSTGRHNEHEARCSDVTRPLV----SRIAFSTLE 218
            .||||.|:|.:|.|:||:||||||::.||.:.:..:.||.||.|:|....|.    ..||||||:
Zfish   155 AIYKSMDYGRTWTPYQFYSSQCRRMYNRPNKAAITKQNEQEALCTDGHTDLYPLSGGLIAFSTLD 219

  Fly   219 GRPSSRDLDSSPVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLASGKYSVPLANGPAGN 283
            ||||.:|.|||||||||||.|||||||.|     ||...:|.       .||:.|......|
Zfish   220 GRPSGKDFDSSPVLQDWVTVTDIRVVFSR-----PQHTRALP-------MSGRESEDALGAP--- 269

  Fly   284 NIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTDASGQLNCECSHNTAGRDCERCKP 348
                   |.:.|    .:||:.||.||||||||||||:|..:..|:|.|||.|||.|.:|:||||
Zfish   270 -------GSLPT----YYYAVGDFQVGGRCKCNGHASRCVREKDGKLLCECKHNTEGPECDRCKP 323

  Fly   349 FHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNCRHSTTGRNCHQCKE 413
            ||:||||.|||.||||||..||||.|||:||||||:::||...|||||.||||:|.||:||.|||
Zfish   324 FHYDRPWQRATGKEANECLPCNCNLHARRCRFNMELYKLSGRKSGGVCMNCRHNTAGRHCHYCKE 388

  Fly   414 GFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKDGVTGLTCNRCARGYQQSRSHIAP 478
            |||||..|.:|||:.||||||||:|::||.||.|:|||||||||||:||||||:|||||||.:||
Zfish   389 GFYRDMGKAITHRRACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPVAP 453

  Fly   479 CIKQPPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGMAAQSQYYRTEGGRECGKCRVSTKRL 543
            |||.|  :|......:|..||.:.:|                   |.:...|         ..::
Zfish   454 CIKIP--VIKPTAVISTTEEPADCDS-------------------YCKPLKG---------NLKI 488

  Fly   544 NLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVADYEMDQVQPGSARSPITGVYEFQAA 608
            |:.|:||:|||:...|:..:|                 |.|:
Zfish   489 NMKKYCKKDYAVQVSVLDMET-----------------VGDW----------------------- 513

  Fly   609 DYPNPNPNPRGSEMERFDLQIQAVFKRSRPGESSGAGNVYGMPNTTLKRGP-MTWIIPTKDLECR 672
                          .:|.:.:.:|:| ||           |.|   ||||. |.| :..|||.|:
Zfish   514 --------------AKFSVSLMSVYK-SR-----------GDP---LKRGDHMLW-VHMKDLACK 548

  Fly   673 CPRIRVNRSYLILG-RDSEAPPGYLGI--GPHSIVIEWKEDWYRRMKRFQRRAR 723
            ||||.:.:.:|||| .:..|.|...|:  ..:|:||:|::.|.||:::|||:.:
Zfish   549 CPRIHMGKRFLILGSTEGTANPERPGLQADKNSLVIQWRDIWTRRLRKFQRKEK 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_511154.3	LamNT	44..280	CDD:214532	119/244 (49%)
		EGF_Lam	312..357	CDD:238012	30/44 (68%)
		EGF_Lam	369..426	CDD:238012	39/56 (70%)
		EGF_Lam	431..479	CDD:238012	37/47 (79%)
		NTR_netrin-1_like	545..723	CDD:239634	48/181 (27%)
ntn2	NP_001032492.2	Laminin_N	45..286	CDD:459653	126/269 (47%)
		EGF_Lam	287..332	CDD:238012	30/44 (68%)
		EGF_Lam	343..393	CDD:238012	35/49 (71%)
		EGF_Lam	406..454	CDD:238012	37/47 (79%)
		NTR_netrin-1_like	490..606	CDD:239634	48/183 (26%)