Protein Alignment NetA and NTN4

DIOPT Version :10

• Sequence 1: NP_511154.3
• Gene: NetA / 32398
• FlyBaseID: FBgn0015773
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_067052.2
• Gene: NTN4 / 59277
• HGNCID: 13658
• Length: 628
• Species: Homo sapiens
• Alignment Length: 727
• Identity: 184/727 - (25%)
• Similarity: 282/727 - (38%)
• Gaps: 186/727 - (25%)

  Fly    48 RACIPDFVNAAYDAPVVASSTCGSSGAQRYCEYQDH------ERSCHTCDMTDPLRSFPARSLTD 106
            :||.|...|.|....:.|.:|||.:..:.||.|.::      :..|..|:...|..:....::.|
Human    32 KACNPRMGNLALGRKLWADTTCGQNATELYCFYSENTDLTCRQPKCDKCNAAYPHLAHLPSAMAD 96

  Fly   107 LNNSNNVTCWRS-EPVTGSGDNVTLTLSLGKKFELTYVILQLCPHAPRPDSMVIYKSTDHGLSWQ 170
            .:.....|.|:| |.|    ....:.|.|..:|..|::|:..  .:|||.:||:.:|.|.|.:|:
Human    97 SSFRFPRTWWQSAEDV----HREKIQLDLEAEFYFTHLIVMF--KSPRPAAMVLDRSQDFGKTWK 155

  Fly   171 PFQFFSSQCRRLFG------RPARQSTGRHNEHEARCSDVTRPLVSRIAFSTLEGRPSSRDLDSS 229
            |:::|::.|...||      :.....|.:::. ...|:.      ..:.|..| ..|...:...|
Human   156 PYKYFATNCSATFGLEDDVVKKGAICTSKYSS-PFPCTG------GEVIFKAL-SPPYDTENPYS 212

  Fly   230 PVLQDWVTATDIRV-VFHRLQRPDPQALLSLEAGGATDLASGKYSVPLANGPAGNNIEANLGGDV 293
            ..:|:.:..|::|| :..|...|..:..|:.|....|
Human   213 AKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHFT---------------------------- 249

  Fly   294 ATSGSGLHYAISDFSVGGRCKCNGHASKC-------STDASGQLN-----CECSHNTAGRDCERC 346
                   ||||.||.|.|.|.|||||.:|       ...|.|..:     |.|.|||||..|:.|
Human   250 -------HYAIYDFIVKGSCFCNGHADQCIPVHGFRPVKAPGTFHMVHGKCMCKHNTAGSHCQHC 307

  Fly   347 KPFHFDRPWARATAKEA--NECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNCRHSTTGRNCH 409
            .|.:.||||..|..|..  |||:.|.||.||..|.|::.::..|...|||||.:|:|:|.|:.|.
Human   308 APLYNDRPWEAADGKTGAPNECRTCKCNGHADTCHFDVNVWEASGNRSGGVCDDCQHNTEGQYCQ 372

  Fly   410 QCKEGFYRDATKPLTHRKVCKACDCHPIGS------SGKICNSTSGQCPCKDGVTGLTCNRCARG 468
            :||.|||||..:|.:....||.|.|||:||      |...|:.::|.||||.||.|..|:||..|
Human   373 RCKPGFYRDLRRPFSAPDACKPCSCHPVGSAVLPANSVTFCDPSNGDCPCKPGVAGRRCDRCMVG 437

  Fly   469 YQQSRSH--------------IAPCIKQPPRMINMLDTQNTAPE--PDEPESSPGSGGDRNGAAG 517
            |.....:              ...||...    ..:|..:..|:  |...:|.|  ..:...|.|
Human   438 YWGFGDYGCRPCDCAGSCDPITGDCISSH----TDIDWYHEVPDFRPVHNKSEP--AWEWEDAQG 496

  Fly   518 MAAQSQYYRTEGGRECGKCRVSTKRL-NLNKFC--KRDYAIMAKVIGRDTSSEAVSREVQRRAMD 579
            .:|.         ...|||....:.| |...||  |..|.:..|::
Human   497 FSAL---------LHSGKCECKEQTLGNAKAFCGMKYSYVLKIKIL------------------- 533

  Fly   580 PDVADYEMDQVQPGSARSPITGVYEFQAADYPNPNPNPRGSEMERFDLQIQAVFKRSRPGESSGA 644
                                              :.:.:|:.:| .:::|:.|.|.::.....|.
Human   534 ----------------------------------SAHDKGTHVE-VNVKIKKVLKSTKLKIFRGK 563

  Fly   645 GNVYGMPNTTLKRGPMTWIIPTKDLECRCPRIRVNRSYLILGRDSEAPPGYLGIGPHSIVIEWKE 709
            ..:|          |.:|    .|..|.||.:.....||:.|.: :...|.|.:...|.|..||.
Human   564 RTLY----------PESW----TDRGCTCPILNPGLEYLVAGHE-DIRTGKLIVNMKSFVQHWKP 613

  Fly   710 DWYRRMKRFQRR 721
            ...|::....:|
Human   614 SLGRKVMDILKR 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_511154.3	LamNT	44..280	CDD:214532	55/245 (22%)
		EGF_Lam	312..357	CDD:238012	23/56 (41%)
		EGF_Lam	369..426	CDD:238012	26/56 (46%)
		EGF_Lam	431..479	CDD:238012	21/67 (31%)
		NTR_netrin-1_like	545..723	CDD:239634	29/179 (16%)
NTN4	NP_067052.2	Laminin_N	34..260	CDD:459653	61/274 (22%)
		EGF_Lam	261..320	CDD:238012	23/58 (40%)
		Laminin_EGF	332..392	CDD:395007	26/59 (44%)
		EGF_Lam	395..446	CDD:214543	21/50 (42%)
		NTR_netrin-4_like	516..626	CDD:239633	29/179 (16%)