Protein Alignment NetA and Ntn4

DIOPT Version :10

• Sequence 1: NP_511154.3
• Gene: NetA / 32398
• FlyBaseID: FBgn0015773
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_067295.2
• Gene: Ntn4 / 57764
• MGIID: 1888978
• Length: 628
• Species: Mus musculus
• Alignment Length: 734
• Identity: 187/734 - (25%)
• Similarity: 286/734 - (38%)
• Gaps: 200/734 - (27%)

  Fly    48 RACIPDFVNAAYDAPVVASSTCGSSGAQRYCEYQDH------ERSCHTCDMTDPLRSFPARSLTD 106
            :||.|...|.|....:.|.:.||.:..:.:|.|.::      :..|..|:......:.|..::.|
Mouse    32 KACNPRMGNLALGRKLRADTMCGQNATELFCFYSENADLTCRQPKCDKCNAAHSHLAHPPSAMAD 96

  Fly   107 LNNSNNVTCWRS-EPVTGSGDNVTLTLSLGKKFELTYVILQLCPHAPRPDSMVIYKSTDHGLSWQ 170
            .:.....|.|:| |.|    ....:.|.|..:|..|::|:..  .:|||.:||:.:|.|.|.:|:
Mouse    97 SSFRFPRTWWQSAEDV----HREKIQLDLEAEFYFTHLIMVF--KSPRPAAMVLDRSQDFGKTWK 155

  Fly   171 PFQFFSSQCRRLFG------RPARQSTGRHNEHEARCSDVTRPLVSRIAFSTLEGRPSSRDLDSS 229
            |:::|::.|...||      :.....|.|:: :...|:.      ..:.|..| ..|...:...|
Mouse   156 PYKYFATNCSATFGLEDDVVKKGAICTSRYS-NPFPCTG------GEVIFRAL-SPPYDIENPYS 212

  Fly   230 PVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLASGKYSVPLANGPAGNNIEANLGGDVA 294
            ..:|:.:..|::||   ||.:                    :.|.|...    |::.|.
Mouse   213 AKVQEQLKITNLRV---RLLK--------------------RQSCPCQI----NDLNAK------ 244

  Fly   295 TSGSGLHYAISDFSVGGRCKCNGHASKC-------STDASGQLN-----CECSHNTAGRDCERCK 347
             ....:|||:.||.|.|.|.|||||.:|       ...|.|..:     |.|.|||||..|:.|.
Mouse   245 -PHHFMHYAVYDFIVKGSCFCNGHADQCLPVEGFRPIKAPGAFHVVHGRCMCKHNTAGSHCQHCA 308

  Fly   348 PFHFDRPWARATAKEA--NECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNCRHSTTGRNCHQ 410
            |.:.||||..|..:..  |||:.|.||.||..|.|::.::..|...|||||.||:|:|.|::|.:
Mouse   309 PLYNDRPWEAADGRTGAPNECRTCKCNGHADTCHFDVNVWEASGNRSGGVCNNCQHNTEGQHCQR 373

  Fly   411 CKEGFYRDATKPLTHRKVCKACDCHPIG------SSGKICNSTSGQCPCKDGVTGLTCNRCARGY 469
            ||.|||||..:|.:....||||.|||:|      ||...|:.::|.||||.||.|..|:||..||
Mouse   374 CKPGFYRDLRRPFSAPDACKACSCHPVGSAILPFSSVTFCDPSNGDCPCKPGVAGPHCDRCMVGY 438

  Fly   470 QQSRSH-IAPC----------------------IKQPPRMINMLDTQNTAPEPD-EPESSPGSGG 510
            .....: ..||                      ..:.|...:|    :...||. |.|
Mouse   439 WGFGDYGCRPCDCAGSCDPLTGDCISSNADVDWYHEVPAFHSM----HNKSEPSWEWE------- 492

  Fly   511 DRNGAAGMAAQSQYYRTEGGRECGKCRVSTKRL-NLNKFC--KRDYAIMAKVIGRDTSSEAVSRE 572
            |..|.:.:            |..|||....:.| |...||  |..|.:..|::
Mouse   493 DEQGFSAL------------RHSGKCECKEQVLGNPKAFCGMKYSYVLKIKIL------------ 533

  Fly   573 VQRRAMDPDVADYEMDQVQPGSARSPITGVYEFQAADYPNPNPNPRGSEMERFDLQIQAVFKRSR 637
                                                     :.:.:||..| .:::|:.|.|.::
Mouse   534 -----------------------------------------SAHDKGSHAE-VNVKIKKVLKSTK 556

  Fly   638 PGESSGAGNVYGMPNTTLKRGPMTWIIPTKDLECRCPRIRVNRSYLILGRDSEAPPGYLGIGPHS 702
            .....|...:|  |.:...||            |.||.:.....||:.|.: :...|.|.:...|
Mouse   557 LKILRGKRTLY--PESWTNRG------------CTCPILNPGLEYLVAGHE-DVRTGKLIVNMKS 606

  Fly   703 IVIEWKEDWYRRMKRFQRR 721
            .|..||....||:....:|
Mouse   607 FVQHWKPALGRRVMHILKR 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_511154.3	LamNT	44..280	CDD:214532	53/244 (22%)
		EGF_Lam	312..357	CDD:238012	23/56 (41%)
		EGF_Lam	369..426	CDD:238012	27/56 (48%)
		EGF_Lam	431..479	CDD:238012	22/54 (41%)
		NTR_netrin-1_like	545..723	CDD:239634	31/179 (17%)
Ntn4	NP_067295.2	Laminin_N	34..260	CDD:459653	60/273 (22%)
		EGF_Lam	261..320	CDD:238012	23/58 (40%)
		Laminin_EGF	332..392	CDD:395007	27/59 (46%)
		EGF_Lam	395..446	CDD:214543	21/50 (42%)
		NTR_netrin-4_like	517..626	CDD:239633	31/178 (17%)