DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetA and lama1

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001030158.1	Gene:	lama1 / 569971	ZFINID:	ZDB-GENE-060118-1	Length:	3075	Species:	Danio rerio

Alignment Length:	642	Identity:	180/642 - (28%)
Similarity:	267/642 - (41%)	Gaps:	151/642 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLLLGTTRFSPIQCISNDVYFKMFSQQAPPEDPCYNKAHEPRACIPDFVNAAYDAPVVASSTCG 70
            :|.||... ||.:.|:.        :||              |...|..:|.|.:|.:..::|||
Zfish     8 MLWLLALV-FSSVICVE--------AQQ--------------RGLFPAILNLASNAEISTNATCG 49

  Fly    71 SSGAQRYCEYQDH-------ERSCHTCDMT--DPLRSFPARSLTDLNNSNNVTCWRSEPVTGSGD 126
            ....:.:|:..:|       ...|..||..  :|....|..:..|..|     .|...|...:|.
Zfish    50 DPDPEMFCKLVEHVPGRRIRNPQCRICDANSQNPKEQHPITNAIDGTN-----LWWQSPSIKNGR 109

  Fly   127 N---VTLTLSLGKKFELTYVILQLCPHAPRPDSMVIYKSTDHGLSWQPFQFFS---SQCRRLF-- 183
            .   ||:||.|.:.|::.|:|:: ..::|||.:.::.:|.| |:::||:||::   ::|...:
Zfish   110 QFHWVTVTLDLRQVFQVAYIIIK-AANSPRPGNWILERSLD-GVNFQPWQFYAISDTECLTRYNI 172

  Fly   184 ----GRPARQSTGRHNEHEARCSDVTRPLV----SRIAFSTLEGRPSSRDLDSSPVLQDWVTATD 240
                |.|..:     .:.|..|:.....||    ..|..|.:.||||:.||  :|.|.::.:|..
Zfish   173 TPRIGPPTYK-----RDDEVICTSYYSRLVPLEHGEIHTSLINGRPSADDL--TPELLEFTSARF 230

  Fly   241 IRVVFHRLQRPDPQALLSLEAGGATDLASGKYSVPLANGPAGNNIEANLGGDVATSGSGLHYAIS 305
            ||:   ||||     :.:|.|    ||.:..|..|....|            :.|  ...:|:|.
Zfish   231 IRL---RLQR-----IRTLNA----DLMTLSYRDPKDVDP------------IVT--RRYYYSIK 269

  Fly   306 DFSVGGRCKCNGHASKCSTD-ASGQLNCECSHNTAGRDCERCKPFHFDRPWARATAKEANECKEC 369
            |.||||.|.|.|||..|..| .:.:|.|.|.|||.|..|..|.|.:...||...|..:.|.|::|
Zfish   270 DISVGGMCICYGHAQSCPWDPVTKKLQCVCEHNTCGESCNECCPGYHQEPWQPGTLSDGNTCEKC 334

  Fly   370 NCNKHARQCRFNMEI--FRLS-----QGVSGGVCQNCRHSTTGRNCHQCKEGFYRDATKPLTHRK 427
            ||:..|..|.:|..:  .:||     |...||||.||||:|.|.||..|.:|:||.........:
Zfish   335 NCHNKADDCFYNQTVADLKLSMNTHGQFTGGGVCVNCRHNTAGVNCETCADGYYRPHQVSPYAEE 399

  Fly   428 VCKACDCHPIGSSGKIC-----------NSTSGQCPCKDGVTGLTCNRCARGYQQ----SRSHIA 477
            .|..|.|...||...:|           ..:.|||.||:|..|..|:|||.|::.    ||   .
Zfish   400 PCVECQCDMRGSVSPVCIRDDNHANPDAGLSPGQCVCKEGFAGEKCDRCAFGFRDFPVCSR---C 461

  Fly   478 PCIKQPPRMINMLDTQNTAP--EPDEPESSPGSGGD--RNGAAGMAAQSQYYRTEGGRECGKCRV 538
            .|        |:..:.||.|  |.....:..||..|  :.|...:.|.:    .||..|| .|
Zfish   462 EC--------NLDGSHNTDPCMECVCKANVMGSHCDLCKQGFYNLQASN----PEGCTEC-FC-- 511

  Fly   539 STKRLNLNKFCKRDYAIMAKVIGRD--------TSS---EAVSRE---VQRRAMDPD 581
                ..::..|:......:.|:.||        ||.   ..||.|   :..|:.|.|
Zfish   512 ----FGVSDVCESSTWFSSSVVHRDGVLHRLHQTSISFWSPVSDENLIISNRSTDAD 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	68/260 (26%)
		EGF_Lam	312..357	CDD:238012	19/45 (42%)
		EGF_Lam	369..426	CDD:238012	25/63 (40%)
		EGF_Lam	431..479	CDD:238012	19/62 (31%)
		NTR_netrin-1_like	545..723	CDD:239634	12/51 (24%)
lama1	NP_001030158.1	LamNT	25..275	CDD:214532	77/303 (25%)
		EGF_Lam	277..324	CDD:238012	19/46 (41%)
		EGF_Lam	<364..390	CDD:238012	15/25 (60%)
		Laminin_EGF	404..463	CDD:278482	19/61 (31%)
		Laminin_EGF	461..506	CDD:278482	12/56 (21%)
		Laminin_B	571..699	CDD:278481
		EGF_Lam	744..792	CDD:238012
		Laminin_EGF	809..849	CDD:278482
		EGF_Lam	851..903	CDD:238012
		Laminin_EGF	905..951	CDD:278482
		Laminin_EGF	954..1001	CDD:278482
		EGF_Lam	1000..1045	CDD:238012
		Laminin_EGF	1047..1095	CDD:278482
		Laminin_EGF	1093..1149	CDD:278482
		Laminin_B	1221..1346	CDD:278481
		EGF_Lam	<1365..1385	CDD:238012
		Laminin_EGF	1407..1453	CDD:278482
		Laminin_EGF	1456..1509	CDD:278482
		Laminin_EGF	1512..>1549	CDD:278482
		Laminin_I	1580..1842	CDD:283627
		Baculo_PEP_C	1581..1711	CDD:282382
		Laminin_II	2015..2148	CDD:283628
		LamG	2133..2281	CDD:238058
		LamG	2310..2466	CDD:238058
		LamG	2491..2641	CDD:238058
		Laminin_G_1	2750..2877	CDD:278483
		LamG	2897..3048	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910