DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetA and ntn4

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	XP_009301345.1	Gene:	ntn4 / 561440	ZFINID:	ZDB-GENE-050310-1	Length:	639	Species:	Danio rerio

Alignment Length:	715	Identity:	192/715 - (26%)
Similarity:	276/715 - (38%)	Gaps:	197/715 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 CYNKAHEPRACIPDFVNAAYDAPVVASSTCGSSGAQRYCEYQDHE--RSCHTCDMTDPLRSFPAR 102
            |.|     |.|.|...|.|...|:...|.|||:..:::|.|:...  ..|..||.:....:....
Zfish    74 CVN-----RVCNPRMGNLAVGRPIQTVSQCGSTSPEQFCMYRPDSCVLDCEICDASVSQHAHSPS 133

  Fly   103 SLTDLNNSNNVTCWRSEPVTGSGDNVTLTLSLGKKFELTYVILQLCPHAPRPDSMVIYKSTDHGL 167
            |:||......:|.|:|.|.|..   .||.|.|..:|..|::|:...  :|||.:|.|.:|.|.|.
Zfish   134 SMTDSPFKQPLTWWQSAPGTAI---ETLQLDLEVEFYFTHLIIIFM--SPRPAAMAIDRSRDFGQ 193

  Fly   168 SWQPFQFFSSQCRRLFGRPARQSTGRHNEHEARCSDVTRPLVSRIAFSTLEG--RPSSRDLDSSP 230
            :|.....||                 ||     ||:|          |:||.  |.:::...:.|
Zfish   194 TWSLLMLFS-----------------HN-----CSEV----------SSLEDGQRCTAKYSSAEP 226

  Fly   231 VLQDWVTATDIRVVFHRL---QRPDPQALLSLEAGGATD-----LASGKYSVPLANGPAGNNIEA 287
                   .|:..|::..|   :|.||.:..:....|.|:     |.......|:|:..|
Zfish   227 -------CTNGEVIYRALSPYERLDPYSTDARSLLGVTNVRIRLLQPHSCPCPIADANA------ 278

  Fly   288 NLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTDASGQLN------------CECSHNTAG 340
                  ||.    .|||||..:.|.|.|:|||.:| ....|:.|            |.|.|:|||
Zfish   279 ------ATP----RYAISDLILKGGCLCHGHADQC-VPTGGKHNSKTFGKHVVHGKCLCRHHTAG 332

  Fly   341 RDCERCKPFHFDRPW--ARATAKEANECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNCRHST 403
            ..||||...:.||||  |.....|||:|.||.||.||..|.|:..::..|....|||| :|.|:|
Zfish   333 DHCERCHRLYNDRPWRAADGLTGEANQCVECKCNGHAESCHFDESVWLRSGQQHGGVC-DCLHNT 396

  Fly   404 TGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKDGVTGLTCNRCARG 468
            ||::|..|:.|||||..||.|....|..|.|:.:|||  .|...:|:|.||.||.|..|.:|..|
Zfish   397 TGQHCQHCQSGFYRDPEKPSTAPDSCTPCMCNHVGSS--YCKPDNGECVCKPGVAGRHCEQCMLG 459

  Fly   469 YQQSRSHIAPCIKQPPRMINMLDTQNTAPEPDEPESSPGSG-------GDRNGAAGMAAQSQYYR 526
            |..                  ||.....|.....:..|.:|       .|.|.    .|::..:|
Zfish   460 YWG------------------LDEYGCKPCQCAGDCDPYTGDCMIRSESDDNS----TAENHLFR 502

  Fly   527 TE----GGRECGKCRVSTKRLNLNK-FCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVADYE 586
            ||    ......||....:.|..:| ||...||...||
Zfish   503 TEELFSALSHPDKCICKQQALGNSKVFCNAKYAYAVKV--------------------------- 540

  Fly   587 MDQVQPGSARSPITGVYEFQAADYPNPNPNPRGSEMERFDLQI-QAVFKRSRPGESSGAGNVYGM 650
                       .:.|.::             :||..| .|::| :.::..:|...|.|:..:|
Zfish   541 -----------RVLGAHD-------------KGSHAE-VDVKILKVLWDNTRLRLSRGSRTLY-- 578

  Fly   651 PNTTLKRGPMTWIIPTKDLECRCPRIRVNRSYLILGRDSEAPPGYLGIGPHSIVIEWKEDWYRRM 715
            |.:.:.||            |.||.:.....||::|.: :...|...:...|||..|:....|::
Zfish   579 PESWMSRG------------CTCPVLFPGLEYLVVGHE-DVRKGRPVVNMKSIVKPWRASLSRKV 630

Fly 716 715
Zfish 631 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	62/247 (25%)
		EGF_Lam	312..357	CDD:238012	22/58 (38%)
		EGF_Lam	369..426	CDD:238012	27/56 (48%)
		EGF_Lam	431..479	CDD:238012	17/47 (36%)
		NTR_netrin-1_like	545..723	CDD:239634	32/173 (18%)
ntn4	XP_009301345.1	Laminin_N	89..292	CDD:278484	65/262 (25%)
		EGF_Lam	294..351	CDD:238012	22/57 (39%)
		Laminin_EGF	363..422	CDD:278482	27/59 (46%)
		EGF_Lam	425..468	CDD:214543	19/62 (31%)
		NTR_netrin-4_like	526..637	CDD:239633	32/172 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910