DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetA and lamc3

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	XP_687343.5	Gene:	lamc3 / 558958	ZFINID:	ZDB-GENE-060531-121	Length:	1643	Species:	Danio rerio

Alignment Length:	586	Identity:	203/586 - (34%)
Similarity:	275/586 - (46%)	Gaps:	148/586 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 IRGILLLLLGTTRFSPIQCISNDVYFKMFSQQAPPEDPCYNKAHEPRACIPDFVNAAYDAPVVAS 66
            :..:||||..:            ||| :|:..    |.||::...|..|:|.|.|||::..|:.|
Zfish     6 LHSLLLLLFAS------------VYF-VFAGM----DSCYDENGVPSLCLPKFENAAFNHSVMVS 53

  Fly    67 STCGSSGAQRYCEYQDHERSCHTCDMTDPLRSFPARSLTDLNNSNNVTCWRSEPV---TGSGDNV 128
            :.||.. .:.||......||||.||..|...:..|..|||.:.....|.|:|:.:   ....::|
Zfish    54 NMCGIP-PEDYCMQTGSTRSCHHCDAFDSELNRNATYLTDFHTDEEPTWWQSQSMFYGVQYPNSV 117

  Fly   129 TLTLSLGKKFELTYVILQLCPHAPRPDSMVIYKSTDHGLSWQPFQFFSSQCRRLFGRPARQSTG- 192
            .:||.|||.||:|||.|:.  :..||:|..|||.||....|||:|::|:.||:.:|   |.:.|
Zfish   118 NITLHLGKAFEITYVRLKF--YTSRPESFAIYKRTDENGPWQPYQYYSASCRKTYG---RDNKGF 177

  Fly   193 ---RHNEHEARC----SDVTRPLVSRIAFSTLEGRPSSRDLDSSPVLQDWVTATDIRVVFHRLQR 250
               ..||....|    ||::......:||||||||||:.:.|.|.|||||||||||.:...||
Zfish   178 IRPGDNERTPLCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDQSLVLQDWVTATDILISLDRL-- 240

  Fly   251 PDPQALLSLEAGGATDLASGKYSVPLANGPAGNNIEANLGGDV----ATSGSGLHYAISDFSVGG 311
                                                 |..||.    |.......||||||||||
Zfish   241 -------------------------------------NTFGDEFFKDAKVLRSYFYAISDFSVGG 268

  Fly   312 RCKCNGHASKCSTDASGQLNCECSHNTAGRDCERCKPFHFDRPWARATAKEANECKECNCNKHAR 376
            |||||||||:|..:..|:..|.|.|||||.||:.|.||:.|||||||||..||||..|||:..|.
Zfish   269 RCKCNGHASECVVNEEGRSVCVCEHNTAGVDCQLCAPFYQDRPWARATAHSANECVRCNCSGLAD 333

  Fly   377 QCRFNMEIFRLSQGVSGGVCQNCRHSTTGRNCHQCKEGFYR-DATKPLTHRKVCKACDCHPIGSS 440
            :|.|::|.:| |.| .||.|..||.:|.|.:|.||:|.::| .|.:|      |:.|:|:.:||.
Zfish   334 ECVFDVEQYR-STG-QGGRCLGCRENTAGPHCEQCRENYFRSSALQP------CQNCNCNALGSV 390

  Fly   441 GKICNSTSGQCPCKDGVTGLTCNRCARGYQQSRSHIAPCIKQPPRMINMLDTQNTAPEPDEPESS 505
            ...|:: .|.|.|...|:|:.|:.|..|:.                                  |
Zfish   391 SLQCDA-DGVCVCWPSVSGVKCDICKSGFH----------------------------------S 420

  Fly   506 PGSGG------DRNGAAGMAAQSQYYRTEG---------GRECGKCRVSTKRLNL------NK-F 548
            .|.||      |..|:.|:.:..     :|         |:.|.:|:..:..|.|      || |
Zfish   421 LGPGGCRLCDCDERGSVGVCSAE-----DGRCHCKANVEGQSCNRCKPGSFNLQLENPDGCNKCF 480

  Fly   549 C 549
            |
Zfish   481 C 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	87/246 (35%)
		EGF_Lam	312..357	CDD:238012	27/44 (61%)
		EGF_Lam	369..426	CDD:238012	24/57 (42%)
		EGF_Lam	431..479	CDD:238012	13/47 (28%)
		NTR_netrin-1_like	545..723	CDD:239634	5/12 (42%)
lamc3	XP_687343.5	Laminin_N	46..268	CDD:278484	92/266 (35%)
		EGF_Lam	269..314	CDD:238012	27/44 (61%)
		Laminin_EGF	326..382	CDD:278482	25/63 (40%)
		EGF_Lam	382..426	CDD:214543	16/78 (21%)
		Laminin_EGF	429..476	CDD:278482	9/51 (18%)
		Laminin_B	540..659	CDD:278481
		EGF_Lam	710..751	CDD:238012
		Laminin_EGF	814..861	CDD:278482
		EGF_Lam	871..921	CDD:238012
		Laminin_EGF	923..971	CDD:278482
		EGF_Lam	970..1010	CDD:238012
		ApoLp-III_like	1233..1386	CDD:304399
		PspA	1388..1607	CDD:224755
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	2	1.870