Protein Alignment NetA and lamb2l

DIOPT Version :10

• Sequence 1: NP_511154.3
• Gene: NetA / 32398
• FlyBaseID: FBgn0015773
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: XP_692838.6
• Gene: lamb2l / 553337
• ZFINID: ZDB-GENE-030131-4205
• Length: 1836
• Species: Danio rerio
• Alignment Length: 728
• Identity: 194/728 - (26%)
• Similarity: 291/728 - (39%)
• Gaps: 220/728 - (30%)

  Fly    47 PRACIPDFVNAAYDAP----------VVASSTCGSSGAQRYC---EYQDHERSCHTCDMTDPLRS 98
            |..|:.   .:.|.|.          :..|||||..|.:.||   ..:|.|: |..||..:|
Zfish    24 PHGCMD---GSCYPATGNLLIGRAINLTTSSTCGLDGPEPYCIVSHLKDSEK-CFICDSENP--- 81

  Fly    99 FPARSLTDLNNSNNV----------TCWRSEPVTGSGDNVTLTLSLGKKFELTYVILQLCPHAPR 153
            :.|....|.:...||          |.|::  |.|. :||::.|:|..:|..|::|::.  ...|
Zfish    82 YDANYHRDSHRVENVIYPMDSTGELTWWQA--VNGE-ENVSVRLNLEAEFHFTHLIMKF--KTFR 141

  Fly   154 PDSMVIYKSTDHGLSWQPFQFFSSQCRRLFGRPARQSTGRHNE--HEARCSDVTRPLVSRIAFST 216
            |.:|:|.:|:|.|.:|:.:::|:..|.:.|.|....|....:|  .|.|.||:.......:.:..
Zfish   142 PAAMIIERSSDFGRTWRIYRYFAYNCTKTFPRVPAHSLRFIDEVICEERYSDIEPSTDGEVIYKV 206

  Fly   217 LEGRPSSRD---LDSSPVLQDWVTATDIRVVFHRL---------QRPDPQALLSLEAGGATDLAS 269
            |:.....:|   ||    :||.:..|::|:.|.:|         :|||               ..
Zfish   207 LDPAIHVKDPYSLD----IQDLLRITNLRINFTKLHTLGDNLLDRRPD---------------VL 252

  Fly   270 GKYSVPLANGPAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKC------STDASG 328
            .||                            :||:.:..|.|.|.|.||||:|      :|..||
Zfish   253 QKY----------------------------YYALYELVVRGSCFCYGHASECAPVPGVTTRDSG 289

  Fly   329 QLN--CECSHNTAGRDCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQGV 391
            .::  |.|.|||.|.:||||:.|:.|.||..|....|:.|:|||||.|:.||.|:|.::..:..|
Zfish   290 MIHGRCVCKHNTVGLNCERCRDFYHDAPWRPAETDNAHTCRECNCNGHSNQCHFDMAVYLATGNV 354

  Fly   392 SGGVCQNCRHSTTGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGS-SGKICNS--------T 447
            |||||.||.|:|.||||..||..:|:|..|.:.....|..|||.|:|| .|.:|:|        .
Zfish   355 SGGVCNNCLHNTMGRNCESCKPFYYQDPEKDIRDPAACVPCDCDPVGSVEGGVCDSHTDLDLGMI 419

  Fly   448 SGQCPCKDGVTGLTCNRCARG-YQQSRSHIAPCIKQP----PRMINMLDTQNTAPEPDEPESSPG 507
            .|||.||..|.|..|:.|..| |..|......|  ||    ||.|..|..      |.:..|
Zfish   420 GGQCRCKQNVRGQRCDYCKEGHYGLSLDDPLGC--QPCNCDPRGITTLGV------PCDQIS--- 473

  Fly   508 SGGDRNGAAGMAAQSQYYRTEGGRECGKCRVSTKRLNLN----KFCKRDYAIMAKVIGRDTSSEA 568
              ||        ...:.|.|  ||.|.:|......|:.:    :.|..|:       |..|||
Zfish   474 --GD--------CSCKRYVT--GRYCNQCLPEYWGLSHDLAGCRPCNCDF-------GGATSS-- 517

  Fly   569 VSREVQRRAMD-------PDVADYEMDQVQPGSARSPITGVYEFQA--------ADYPNP-NPNP 617
                  |..||       |.:...:..:|||....:.: ..|:::|        .|...| :|.|
Zfish   518 ------RCMMDSGQCDCRPHLIGRQCSEVQPAFFCASL-DYYKYEAEAVMGRSPEDLTLPGSPRP 575

  Fly   618 RG---------------------SEMERFDLQ----------IQAVFKRSRPGE----------- 640
            :.                     ::.:|..|:          :.:|.:..:||:
Zfish   576 QAETDCVQHLNNQLRRHRRHRHIAQQQRAALRRIRQLQQTPSVSSVHRERQPGQMVTWTGPGFAR 640

  Fly   641 -SSGAGNVYGMPN 652
             ..|||..:.:.|
Zfish   641 VKDGAGLEFAISN 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_511154.3	LamNT	44..280	CDD:214532	66/269 (25%)
		EGF_Lam	312..357	CDD:238012	24/52 (46%)
		EGF_Lam	369..426	CDD:238012	28/56 (50%)
		EGF_Lam	431..479	CDD:238012	21/57 (37%)
		NTR_netrin-1_like	545..723	CDD:239634	28/171 (16%)
lamb2l	XP_692838.6	Laminin_N	32..266	CDD:459653	67/289 (23%)
		EGF_Lam	267..320	CDD:238012	24/52 (46%)
		EGF_Lam	332..384	CDD:238012	27/51 (53%)
		Laminin_EGF	395..452	CDD:395007	21/56 (38%)
		EGF_Lam	454..505	CDD:238012	16/71 (23%)
		EGF_Lam	506..>545	CDD:238012	13/53 (25%)
		EGF_Lam	816..861	CDD:214543
		Laminin_EGF	864..912	CDD:395007
		EGF_Lam	910..954	CDD:238012
		Laminin_EGF	960..1016	CDD:395007
		Laminin_EGF	1019..1063	CDD:395007
		Laminin_EGF	<1089..1129	CDD:395007
		EGF_Lam	1126..1168	CDD:238012
		Laminin_EGF	1175..1215	CDD:395007
		COG4372	1245..>1436	CDD:443500
		Mplasa_alph_rch	1492..>1818	CDD:275316
		cc_LAMB_C	1766..1835	CDD:411969