Protein Alignment NetA and NTN3

DIOPT Version :10

• Sequence 1: NP_511154.3
• Gene: NetA / 32398
• FlyBaseID: FBgn0015773
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_006172.1
• Gene: NTN3 / 4917
• HGNCID: 8030
• Length: 580
• Species: Homo sapiens
• Alignment Length: 737
• Identity: 292/737 - (39%)
• Similarity: 363/737 - (49%)
• Gaps: 190/737 - (25%)

  Fly     6 LLLLLGTTRFSPIQCISNDVYFKMFSQQAP----PEDPCYNKAHEPRACIPDFVNAAYDAPVVAS 66
            |||..||                :|:..:|    |.|||:::...||.|:|..||||....|:||
Human     8 LLLTAGT----------------LFAALSPGPPAPADPCHDEGGAPRGCVPGLVNAALGREVLAS 56

  Fly    67 STCGSSGAQRYCEYQDHERSCHTCDMTDPLRSFPARSLTDLNNSNNVTCWRSEPVTGSGDNVTLT 131
            ||||....:             .||.:||.|:.....||....:.:..|||||.:..:..|||||
Human    57 STCGRPATR-------------ACDASDPRRAHSPALLTSPGGTASPLCWRSESLPRAPLNVTLT 108

  Fly   132 LSLGKKFELTYVILQLCPHAPRPDSMVIYKSTDHGLSWQPFQFFSSQCRRLFGR---PARQSTGR 193
            :.|||.|||.:|.|:.| .|| |.|:.:.||.|||.||.|..||||.|...:||   ||....|
Human   109 VPLGKAFELVFVSLRFC-SAP-PASVALLKSQDHGRSWAPLGFFSSHCDLDYGRLPAPANGPAG- 170

  Fly   194 HNEHEARCSDVTRPLV-----SRIAFSTLEGRPSSRDLDSSPVLQDWVTATDIRVVFHRLQRPDP 253
             ...||.|  ...||.     ..:|||..:..|...||||||||||||||||:|||   |.||.
Human   171 -PGPEALC--FPAPLAQPDGSGLLAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVV---LTRPS- 228

  Fly   254 QALLSLEAGGATDLASGKYSVPLANGPAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGH 318
                  .||...|:.:   .||.:                        ||.:|..||||||||||
Human   229 ------TAGDPRDMEA---VVPYS------------------------YAATDLQVGGRCKCNGH 260

  Fly   319 ASKCSTDASGQLNCECSHNTAGRDCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNME 383
            ||:|..|..|.|.|:|.|.|.|.||.|||||:.||||.||||:|::.|..|:||.|||:||||||
Human   261 ASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNME 325

  Fly   384 IFRLSQGVSGGVCQNCRHSTTGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTS 448
            ::|||...|||||.||||:|.||:||.|:||||||..:.|:.|:.|:||||||:|::||.||.|:
Human   326 LYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTT 390

  Fly   449 GQCPCKDGVTGLTCNRCARGYQQSRSHIAPCIKQPPRMINMLDTQNTAPEPDEPESSPGSGGDRN 513
            ||||||||||||||||||.|:|||||.:|||:|.|            .|.|.| :|||....|.:
Human   391 GQCPCKDGVTGLTCNRCAPGFQQSRSPVAPCVKTP------------IPGPTE-DSSPVQPQDCD 442

  Fly   514 GAAGMAAQSQYYRTEGGRECGKCRVSTKRLNLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAM 578
            .                 .|...| .:.|::|.||||:|||:...|..|
Human   443 S-----------------HCKPAR-GSYRISLKKFCKKDYAVQVAVGAR---------------- 473

  Fly   579 DPDVADYEMDQVQPGSARSPITGVYEFQAADYPNPNPNPRGSEMERFDLQIQAVFKRSRPGESSG 643
                          |.||...|                       ||.:.:.|||   |.||...
Human   474 --------------GEARGAWT-----------------------RFPVAVLAVF---RSGEERA 498

  Fly   644 AGNVYGMPNTTLKRGPMTWIIPTKDLECRCPRIRVNRSYLILGRDSEAPPGYL-GIGP------H 701
                        :||.....:|..|..|.|||:...|.||:||....|..|.. |.||      .
Human   499 ------------RRGSSALWVPAGDAACGCPRLLPGRRYLLLGGGPGAAAGGAGGRGPGLIAARG 551

  Fly   702 SIVIEWKEDWYRRMKRFQRRAR 723
            |:|:.|::.|.||::|.|||.|
Human   552 SLVLPWRDAWTRRLRRLQRRER 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_511154.3	LamNT	44..280	CDD:214532	99/243 (41%)
		EGF_Lam	312..357	CDD:238012	29/44 (66%)
		EGF_Lam	369..426	CDD:238012	37/56 (66%)
		EGF_Lam	431..479	CDD:238012	37/47 (79%)
		NTR_netrin-1_like	545..723	CDD:239634	50/184 (27%)
NTN3	NP_006172.1	LamNT	34..253	CDD:214532	103/274 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..83		6/33 (18%)
		EGF_Lam	254..299	CDD:238012	29/44 (66%)
		Laminin_EGF	311..362	CDD:395007	36/50 (72%)
		EGF_Lam	373..422	CDD:238012	38/48 (79%)
		NTR_like	456..562	CDD:470599	43/173 (25%)
		Cell attachment site, atypical. /evidence=ECO:0000255	500..502		1/1 (100%)