DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NetA and LAMC1

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_002284.3	Gene:	LAMC1 / 3915	HGNCID:	6492	Length:	1609	Species:	Homo sapiens

Alignment Length:	749	Identity:	237/749 - (31%)
Similarity:	341/749 - (45%)	Gaps:	151/749 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DPCYNKAHEPRACIPDFVNAAYDAPVVASSTCGSSGAQRYC---EYQDHERSCHTCDMTDPLRSF 99
            |.|.::...|:.|:|:|||||::..|||::|||:. .:.||   ......:|||.||...|....
Human    38 DECTDEGGRPQRCMPEFVNAAFNVTVVATNTCGTP-PEEYCVQTGVTGVTKSCHLCDAGQPHLQH 101

  Fly   100 PARSLTDLNNSNNVTCWRSEPVTGS---GDNVTLTLSLGKKFELTYVILQLCPHAPRPDSMVIYK 161
            .|..|||.||..:.|.|:|:.:...   ..::.|||.|||.|::|||.|:.  |..||:|..|||
Human   102 GAAFLTDYNNQADTTWWQSQTMLAGVQYPSSINLTLHLGKAFDITYVRLKF--HTSRPESFAIYK 164

  Fly   162 STDHGLSWQPFQFFSSQCRRLFGRPARQ--STGRHNEHEARC----SDVTRPLVSRIAFSTLEGR 220
            .|.....|.|:|::|..|...:.:..|.  .|| .:|.:|.|    ||::......:||||||||
Human   165 RTREDGPWIPYQYYSGSCENTYSKANRGFIRTG-GDEQQALCTDEFSDISPLTGGNVAFSTLEGR 228

  Fly   221 PSSRDLDSSPVLQDWVTATDIRVVFHRLQR------PDPQALLSLEAGGATDLASGKYSVPLANG 279
            ||:.:.|:|||||:|||||||||..:||..      .||:.|.|
Human   229 PSAYNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKS--------------------- 272

  Fly   280 PAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTDASGQLNCECSHNTAGRDCE 344
                                .:||||||:||||||||||||:|..:...:|.|.|.|||.|.|||
Human   273 --------------------YYYAISDFAVGGRCKCNGHASECMKNEFDKLVCNCKHNTYGVDCE 317

  Fly   345 RCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNCRHSTTGRNCH 409
            :|.||..||||.||||:.|:||..|:||..:::|.|:.|::| |.| .||.|.||:.:|.|.:|.
Human   318 KCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYR-STG-HGGHCTNCQDNTDGAHCE 380

  Fly   410 QCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKDGVTGLTCNRCARGYQQ-SR 473
            :|:|.|:|     |.:.:.|.:|.|.|:||....|:| .|:|.||.||.|..|:||..|:.. :.
Human   381 RCRENFFR-----LGNNEACSSCHCSPVGSLSTQCDS-YGRCSCKPGVMGDKCDRCQPGFHSLTE 439

  Fly   474 SHIAPCIKQPPRMIN--------------------------MLDTQNTAPEPDEPESSPGSGGDR 512
            :...||...|...|:                          ..:.:::.|....|....|.....
Human   440 AGCRPCSCDPSGSIDECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSVC 504

  Fly   513 NGAAGMAAQS---------QYYRTE--GGRECGKCRVSTKRLNL----NKFCKRDYAIMAKVIGR 562
            ..|.|.:..|         ..:|.|  .|.| .....|::|.::    :.:..|.:...||.:|:
Human   505 TNAVGYSVYSISSTFQIDEDGWRAEQRDGSE-ASLEWSSERQDIAVISDSYFPRYFIAPAKFLGK 568

  Fly   563 DTSSE----AVSREVQRRAMDPDVADYEMDQ----------VQPGSARSPITGVYEF---QAADY 610
            ...|.    :.|..|.||.......|..::.          .|..|..|..|..|.|   :|.||
Human   569 QVLSYGQNLSFSFRVDRRDTRLSAEDLVLEGAGLRVSVPLIAQGNSYPSETTVKYVFRLHEATDY 633

  Fly   611 P-NPNPNPRGSEMERFDLQIQAVFKRSRPGESSGAGNVYGMPNTTLKRG---PMTWIIPTKDLEC 671
            | .|...|  .|.::....:.::..|....|.| ||.:..:...:.:.|   |.||:     ..|
Human   634 PWRPALTP--FEFQKLLNNLTSIKIRGTYSERS-AGYLDDVTLASARPGPGVPATWV-----ESC 690

  Fly   672 RCPRIRVNRSY---LILGRDSEAPPGYLGIGPHS 702
            .|| :.....:   .:.|...|.|    .:||:|
Human   691 TCP-VGYGGQFCEMCLSGYRRETP----NLGPYS 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	94/253 (37%)
		EGF_Lam	312..357	CDD:238012	27/44 (61%)
		EGF_Lam	369..426	CDD:238012	22/56 (39%)
		EGF_Lam	431..479	CDD:238012	18/48 (38%)
		NTR_netrin-1_like	545..723	CDD:239634	41/186 (22%)
LAMC1	NP_002284.3	Domain VI	34..285		104/291 (36%)
		LamNT	44..284	CDD:214532	101/284 (36%)
		EGF_Lam	285..330	CDD:238012	27/44 (61%)
		Domain V	286..509		82/230 (36%)
		Laminin_EGF	342..396	CDD:278482	22/60 (37%)
		Laminin_EGF	398..445	CDD:278482	18/47 (38%)
		Laminin_EGF	445..492	CDD:278482	4/46 (9%)
		Domain IV	510..689		39/187 (21%)
		LamB	553..678	CDD:214597	28/127 (22%)
		Domain III	690..1030		9/35 (26%)
		EGF_Lam	724..771	CDD:238012
		EGF_Lam	772..820	CDD:238012
		Laminin_EGF	828..875	CDD:278482
		EGF_Lam	883..933	CDD:238012
		EGF_Lam	935..980	CDD:214543
		EGF_Lam	982..1029	CDD:238012
		Domain I/II	1031..1609
		t_SNARE	1072..1155	CDD:197699
		MA	1091..1302	CDD:214599
		MCP_signal	1123..1255	CDD:304920
		V_Alix_like	1180..>1336	CDD:187408
		Laminin_I	1287..1530	CDD:283627
		SH3BP5	1361..1592	CDD:283045
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870