DRSC/TRiP Functional Genomics Resources

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Protein Alignment NetA and LAMB3

DIOPT Version :10

Sequence 1:NP_511154.3 Gene:NetA / 32398 FlyBaseID:FBgn0015773 Length:726 Species:Drosophila melanogaster
Sequence 2:NP_000219.2 Gene:LAMB3 / 3914 HGNCID:6490 Length:1172 Species:Homo sapiens


Alignment Length:696 Identity:185/696 - (26%)
Similarity:274/696 - (39%) Gaps:184/696 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 MFSQQAPPEDPCYNKAHEPRACIPDFVNAAYDAPVVASSTCGSSGAQRYC-EYQDHERSCHTCDM 92
            :.:|||.....||....:.......|:.        ||||||.:..:.|| :|.:.:..|..||.
Human    15 LHAQQACSRGACYPPVGDLLVGRTRFLR--------ASSTCGLTKPETYCTQYGEWQMKCCKCDS 71

  Fly    93 TDPLRSFPARSLTDLNNSNNVTCWRSEPVTGSGDNVTLTLSLGKKFELTYVILQLCPHAPRPDSM 157
            ..|...:..|.....::|..:..|:|:   ...:.|:|.|.|.::|:|..|:::.  ..|.|..|
Human    72 RQPHNYYSHRVENVASSSGPMRWWQSQ---NDVNPVSLQLDLDRRFQLQEVMMEF--QGPMPAGM 131

  Fly   158 VIYKSTDHGLSWQPFQFFSSQCRRLFGRPARQSTGR-HNEHEARCSDVTRPLVSRIAFSTLEGRP 221
            :|.:|:|.|.:|:.:|:.::.|...|.| .||  || .:..:.||             .:|..||
Human   132 LIERSSDFGKTWRVYQYLAADCTSTFPR-VRQ--GRPQSWQDVRC-------------QSLPQRP 180

  Fly   222 SSR-----------DLDS------SPVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLAS 269
            ::|           ||.|      |..:|:....|::||.|.|| .|.||.              
Human   181 NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRL-APVPQR-------------- 230

  Fly   270 GKYSVPLANGPAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKC----------ST 324
             .|..|.|                       :||:|...:.|.|.|:|||.:|          ||
Human   231 -GYHPPSA-----------------------YYAVSQLRLQGSCFCHGHADRCAPKPGASAGPST 271

  Fly   325 DASGQLNCECSHNTAGRDCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQ 389
            .......|.|.|||||.:||||.||:.:|||..|..::|:||:.|:||.|:..|.|:..:|..||
Human   272 AVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQ 336

  Fly   390 GVSGGVCQNCRHSTTGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGS-SGKICNSTSGQCPC 453
            |..||||.|||..|.|:||.:|:..::|:.....:.::.|.:|:|.|.|: .|..|:..:|||.|
Human   337 GAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVC 401

  Fly   454 KD------------GVTGLT------CNRCARGYQQSRSHIAPCIKQPPRMI------------- 487
            |:            |.||||      |:||......||..: ||.::..|.:             
Human   402 KEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDM-PCDEESGRCLCLPNVVGPKCDQC 465

  Fly   488 -----NMLDTQNTAPEPDEPESS--------PGSGGDRNGAAGMAAQSQYYRTEGGRECGK---- 535
                 .:...|...|...:|.:|        .|....|.|..|:...:...|....|..|.    
Human   466 APYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATG 530

  Fly   536 CRVSTKRLNLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVADYEMDQVQPGSA-RSPI 599
            ||.          |..|:        |.|......:...|....|.:.....||.|.|.. |.|:
Human   531 CRA----------CDCDF--------RGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPV 577

  Fly   600 TGVYE--FQAADYPNPNPNPRGSEMERFDLQIQAV-FKRSRPGESS 642
            .....  ||..|               .||:.||: |.|.|...:|
Human   578 CVACHPCFQTYD---------------ADLREQALRFGRLRNATAS 608

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NetANP_511154.3 LamNT 44..280 CDD:214532 64/254 (25%)
EGF_Lam 312..357 CDD:238012 24/54 (44%)
EGF_Lam 369..426 CDD:238012 23/56 (41%)
EGF_Lam 431..479 CDD:238012 21/66 (32%)
NTR_netrin-1_like 545..723 CDD:239634 23/102 (23%)
LAMB3NP_000219.2 LamNT 20..248 CDD:214532 70/295 (24%)
EGF_Lam 249..304 CDD:238012 24/54 (44%)
Laminin_EGF 316..366 CDD:395007 23/49 (47%)
Laminin_EGF 379..428 CDD:395007 16/48 (33%)
Laminin_EGF 431..478 CDD:395007 7/47 (15%)
Laminin_EGF 481..534 CDD:395007 11/62 (18%)
EGF_Lam 534..576 CDD:214543 11/49 (22%)
Domain II 579..785 11/45 (24%)
GumC 626..>980 CDD:442439
Domain alpha 786..816
Domain I 817..1170
Smc <838..>1092 CDD:440809
cc_LAMB3_C 1102..1172 CDD:411974
Blue background indicates that the domain is not in the aligned region.

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