DRSC/TRiP Functional Genomics Resources

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Protein Alignment NetA and LAMB2

DIOPT Version :10

Sequence 1:NP_511154.3 Gene:NetA / 32398 FlyBaseID:FBgn0015773 Length:726 Species:Drosophila melanogaster
Sequence 2:NP_002283.3 Gene:LAMB2 / 3913 HGNCID:6487 Length:1798 Species:Homo sapiens


Alignment Length:733 Identity:199/733 - (27%)
Similarity:289/733 - (39%) Gaps:224/733 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 GILLLLLGTTRFSPIQCISNDVYFKMFSQQAPPEDPCYNKAHEPRACIP---DFVNAAYDAPVVA 65
            |:||.:|..|                .:|...|:.|..::.    :|.|   |.:....|. :.|
Human    21 GLLLSVLAAT----------------LAQAPAPDVPGCSRG----SCYPATGDLLVGRADR-LTA 64

  Fly    66 SSTCGSSGAQRYC---EYQDHERSCHTCDMTDPLRSFPARSLTDLNNSNNVTC----------WR 117
            |||||.:|.|.||   ..|| |:.|..||...|   |.||.....:...||..          |:
Human    65 SSTCGLNGPQPYCIVSHLQD-EKKCFLCDSRRP---FSARDNPHSHRIQNVVTSFAPQRRAAWWQ 125

  Fly   118 SE---PVTGSGDNVTLTLSLGKKFELTYVILQLCPHAPRPDSMVIYKSTDHGLSWQPFQFFSSQC 179
            ||   |.      ||:.|.|..:|..|::|:..  ...||.:|::.:|.|.|.:|..:::||..|
Human   126 SENGIPA------VTIQLDLEAEFHFTHLIMTF--KTFRPAAMLVERSADFGRTWHVYRYFSYDC 182

  Fly   180 RRLF-GRPARQSTGRHNEH---EARCSDVTRPLVSRIAFSTLEGRPSSRDLDSS-PVLQDWVTAT 239
            ...| |.|.  :..||.:.   |:|.|::.         .:.||....|.||.: |:        
Human   183 GADFPGVPL--APPRHWDDVVCESRYSEIE---------PSTEGEVIYRVLDPAIPI-------- 228

  Fly   240 DIRVVFHRLQRPDPQALLSLEAGGATDLASGKYSVPLANGPAGNNIEANLGGDVATSGSGL---- 300
                       |||                  ||..:.|.....|:..|| ..:.|.|..|    
Human   229 -----------PDP------------------YSSRIQNLLKITNLRVNL-TRLHTLGDNLLDPR 263

  Fly   301 -------HYAISDFSVGGRCKCNGHASKCS------TDASGQLN--CECSHNTAGRDCERCKPFH 350
                   :||:.:..|.|.|.|.||||:|:      ..|.|.::  |.|.|||.|.:||:|:.|:
Human   264 REIREKYYYALYELVVRGNCFCYGHASECAPAPGAPAHAEGMVHGACICKHNTRGLNCEQCQDFY 328

  Fly   351 FDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNCRHSTTGRNCHQCKEGF 415
            .|.||..|....::.|::|.|:.|...|.|:|.::..|..||||||..|:|:|.||:|..|:..|
Human   329 RDLPWRPAEDGHSHACRKCECHGHTHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPFF 393

  Fly   416 YRDATKPLTHRKVCKACDCHPIGS-SGKICNS--------TSGQCPCKDGVTGLTCNRCARGY-- 469
            |||.||.|....||::|||.|:|| .|..|:|        .||||.||:.|.|..|.:|..|:  
Human   394 YRDPTKDLRDPAVCRSCDCDPMGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQQCRDGFFG 458

  Fly   470 --QQSRSHIAPCIKQPPRMINMLDTQNTAP--EPDEPESS--------PGSGGDR--NGAAGMAA 520
              ...|.....|         ..:.:.|.|  .|.:|.|.        .|.|.||  .|..|:: 
Human   459 LSISDRLGCRRC---------QCNARGTVPGSTPCDPNSGSCYCKRLVTGRGCDRCLPGHWGLS- 513

  Fly   521 QSQYYRTEGGRECG---------KCRVSTKRLNLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRR 576
                :...|.|.|.         :|...|.:.:    |::      .::||              
Human   514 ----HDLLGCRPCDCDVGGALDPQCDEGTGQCH----CRQ------HMVGR-------------- 550

  Fly   577 AMDPDVADYEMDQVQPGSARSPITGVYEFQAADYPNPNPNPRGSEMERFDLQIQAVFKRSRPGES 641
                     ..:|||||..| |......::|.|       .||..::       .|.:...|||:
Human   551 ---------RCEQVQPGYFR-PFLDHLIWEAED-------TRGQVLD-------VVERLVTPGET 591

  Fly   642 ---SGAGNVYGMPNTTLK 656
               :|:|.|......||:
Human   592 PSWTGSGFVRLQEGQTLE 609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NetANP_511154.3 LamNT 44..280 CDD:214532 67/259 (26%)
EGF_Lam 312..357 CDD:238012 22/52 (42%)
EGF_Lam 369..426 CDD:238012 27/56 (48%)
EGF_Lam 431..479 CDD:238012 21/60 (35%)
NTR_netrin-1_like 545..723 CDD:239634 23/115 (20%)
LAMB2NP_002283.3 Laminin_N 47..281 CDD:459653 76/295 (26%)
EGF_Lam 283..335 CDD:238012 22/51 (43%)
Laminin_EGF 347..398 CDD:395007 24/50 (48%)
Laminin_EGF 410..467 CDD:395007 21/56 (38%)
EGF_Lam 469..520 CDD:238012 13/64 (20%)
EGF_Lam 521..562 CDD:238012 12/74 (16%)
Laminin_EGF 783..831 CDD:395007
Laminin_EGF 831..879 CDD:395007
EGF_Lam 876..921 CDD:238012
EGF_Lam 926..984 CDD:238012
Laminin_EGF 986..>1028 CDD:395007
EGF_Lam 1037..1093 CDD:238012
Laminin_EGF 1095..1143 CDD:395007
Laminin_EGF 1143..1190 CDD:395007
Domain II 1190..1409
SMC_prok_B <1244..1593 CDD:274008
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1338..1364
Domain alpha 1410..1442
Domain I 1443..1798
Smc <1449..>1786 CDD:440809
cc_LAMB2_C 1727..1798 CDD:411970
Blue background indicates that the domain is not in the aligned region.

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