Protein Alignment NetA and LAMB1

DIOPT Version :10

• Sequence 1: NP_511154.3
• Gene: NetA / 32398
• FlyBaseID: FBgn0015773
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: XP_054214165.1
• Gene: LAMB1 / 3912
• HGNCID: 6486
• Length: 1810
• Species: Homo sapiens
• Alignment Length: 734
• Identity: 188/734 - (25%)
• Similarity: 287/734 - (39%)
• Gaps: 197/734 - (26%)

  Fly    43 KAHEPR--------ACIPD----FVNAAYDAPVVASSTCGSSGAQRYC--EYQDHERSCHTCDMT 93
            :|.||.        :|.|.    .:..|....|  :||||....:.||  .:...::.|..|:..
Human    44 RAQEPEFSYGCAEGSCYPATGDLLIGRAQKLSV--TSTCGLHKPEPYCIVSHLQEDKKCFICNSQ 106

  Fly    94 DPLRSF--PARSLTDLNNSNNVTC---------WRSEPVTGSGDNVTLTLSLGKKFELTYVILQL 147
            ||....  |...|.:    |.||.         |:||   ...:|||:.|.|..:|..|::|:..
Human   107 DPYHETLNPDSHLIE----NVVTTFAPNRLKIWWQSE---NGVENVTIQLDLEAEFHFTHLIMTF 164

  Fly   148 CPHAPRPDSMVIYKSTDHGLSWQPFQFFSSQCRRLFGRPARQSTGRHNE-----HEARCSDVTRP 207
              ...||.:|:|.:|:|.|.:|..:::|:..|...|  |. .|||...:     .::|.||:...
Human   165 --KTFRPAAMLIERSSDFGKTWGVYRYFAYDCEASF--PG-ISTGPMKKVDDIICDSRYSDIEPS 224

  Fly   208 LVSRIAFSTLEGRPSSRDLDS-SPVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLASGK 271
            ....:.|..|:  |:.:..|. ||.:|:.:..|::|:.|.:|.
Human   225 TEGEVIFRALD--PAFKIEDPYSPRIQNLLKITNLRIKFVKLH---------------------- 265

  Fly   272 YSVPLANGPAGNNIEANLGGDVATSGSGL----HYAISDFSVGGRCKCNGHASKC------STDA 326
                            .||.::..|...:    :||:.|..|.|.|.|.||||:|      :.:.
Human   266 ----------------TLGDNLLDSRMEIREKYYYAVYDMVVRGNCFCYGHASECAPVDGFNEEV 314

  Fly   327 SGQL--NCECSHNTAGRDCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQ 389
            .|.:  :|.|.|||.|.:||.|..|:.|.||..|..:.:|.||:||||:|:..|.|:|.::..:.
Human   315 EGMVHGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKCNCNEHSISCHFDMAVYLATG 379

  Fly   390 GVSGGVCQNCRHSTTGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGSSGK-ICNS------- 446
            .||||||.:|:|:|.||||.|||..:|:...:.:.....|:.|.|.|.||..: ||:|
Human   380 NVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPNFCERCTCDPAGSQNEGICDSYTDFSTG 444

  Fly   447 -TSGQCPCKDGVTGLTCNRCARGYQQSRSH----IAPCIKQPPRMI---NMLDTQN--------- 494
             .:|||.||..|.|..|:.|..|:....|.    ...|...|...|   |..|::.
Human   445 LIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFGCKSCACNPLGTIPGGNPCDSETGHCYCKRLV 509

  Fly   495 TAPEPDE--PESSPGSGGDRNGA------AGMAAQSQYYRTEG---------GRECGKCRVSTKR 542
            |....|:  ||.. |...|.:|.      .|.|..:..:...|         ||:|.:....
Human   510 TGQHCDQCLPEHW-GLSNDLDGCRPCDCDLGGALNNSCFAESGQCSCRPHMIGRQCNEVEPG--- 570

  Fly   543 LNLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVADYEMDQVQ--------PGSARSPI 599
               ..|...|:.:.               |.:...:.|.|:..|...:|        .|..|.|.
Human   571 ---YYFATLDHYLY---------------EAEEANLGPGVSIVERQYIQDRIPSWTGAGFVRVPE 617

  Fly   600 TGVYEFQAADYPNPNPNPRGSEME-----RFDLQI-----QAVFKRSRPGE---SSGAGNVYGMP 651
            ....||...:.|        ..||     |::.|:     :||....|||.   ||..||.  :|
Human   618 GAYLEFFIDNIP--------YSMEYDILIRYEPQLPDHWEKAVITVQRPGRIPTSSRCGNT--IP 672

  Fly   652 N-----TTLKRGPMTWIIP 665
            :     .:|..|....::|
Human   673 DDDNQVVSLSPGSRYVVLP 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_511154.3	LamNT	44..280	CDD:214532	62/266 (23%)
		EGF_Lam	312..357	CDD:238012	21/52 (40%)
		EGF_Lam	369..426	CDD:238012	25/56 (45%)
		EGF_Lam	431..479	CDD:238012	19/60 (32%)
		NTR_netrin-1_like	545..723	CDD:239634	30/147 (20%)
LAMB1	XP_054214165.1	Laminin_N	59..293	CDD:459653	66/287 (23%)
		EGF_Lam	295..347	CDD:238012	21/51 (41%)
		EGF_Lam	359..411	CDD:238012	25/51 (49%)
		Laminin_EGF	422..479	CDD:395007	19/56 (34%)
		Laminin_EGF	482..536	CDD:395007	12/54 (22%)
		EGF_Lam	533..>572	CDD:238012	6/44 (14%)
		EGF_Lam	797..842	CDD:214543
		Laminin_EGF	845..893	CDD:395007
		Laminin_EGF	891..938	CDD:395007
		Laminin_EGF	941..997	CDD:395007
		Laminin_EGF	1000..1044	CDD:395007
		Laminin_EGF	1052..1106	CDD:395007
		Laminin_EGF	1108..1156	CDD:395007
		Laminin_EGF	1156..>1195	CDD:395007
		PTZ00121	<1248..1802	CDD:173412
		cc_LAMB1_C	1738..1810	CDD:411971