DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NetA and LAMA5

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	XP_006723859.1	Gene:	LAMA5 / 3911	HGNCID:	6485	Length:	3700	Species:	Homo sapiens

Alignment Length:	726	Identity:	196/726 - (26%)
Similarity:	285/726 - (39%)	Gaps:	171/726 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PDFVNAAYDAPVVASSTCGSSGAQR---------YCEY-------QDHERS-----CHTCDMTDP 95
            |.:.|.|..|.:.||:|||.....|         ||:.       .|..::     |..|...:.
Human    47 PPYFNLAEGARIAASATCGEEAPARGSPRPTEDLYCKLVGGPVAGGDPNQTIRGQYCDICTAANS 111

  Fly    96 LRSFPARSLTDLNNSNNVTCWRSEPVTG--SGDNVTLTLSLGKKFELTYVILQLCPHAPRPDSMV 158
            .::.||.:..|    .....|:|.|::.  ..:.|.:||.||:.|.:.||:::.. ::||||..|
Human   112 NKAHPASNAID----GTERWWQSPPLSRGLEYNEVNVTLDLGQVFHVAYVLIKFA-NSPRPDLWV 171

  Fly   159 IYKSTDHGLSWQPFQFFSSQCRRLFGRPARQSTGRHNEHEAR-CSDVTRPLV----SRIAFSTLE 218
            :.:|.|.|.::||:|||:|..|....|...|:..|....:|. |:.....:|    ..|..|.:.
Human   172 LERSMDFGRTYQPWQFFASSKRDCLERFGPQTLERITRDDAAICTTEYSRIVPLENGEIVVSLVN 236

  Fly   219 GRPSSRDLDSSPVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLASGKYSVPLANGPAGN 283
            |||.:.:...||:|:::..||::|:.|.|.                                  |
Human   237 GRPGAMNFSYSPLLREFTKATNVRLRFLRT----------------------------------N 267

  Fly   284 NIEANLGGDV---ATSGSGLHYAISDFSVGGRCKCNGHASKCS----TDASGQLNCECSHNTAGR 341
            .:..:|.|..   .|.....:|:|.|.|:||||.|:|||..|.    ||.. :|.|.|.|||.|.
Human   268 TLLGHLMGKALRDPTVTRRYYYSIKDISIGGRCVCHGHADACDAKDPTDPF-RLQCTCQHNTCGG 331

  Fly   342 DCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEI--FRLSQGV-----SGGVCQNC 399
            .|:||.|....:||..|||..||||:.|||..||..|.::.|:  .|.||.:     .||||.:|
Human   332 TCDRCCPGFNQQPWKPATANSANECQSCNCYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDC 396

  Fly   400 RHSTTGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKDGVTGLTCNR 464
            :|.|||.||.:|..||||....||....||:.|:|....:.| .|...:|:|.|:...:|..|:.
Human   397 QHHTTGVNCERCLPGFYRSPNHPLDSPHVCRRCNCESDFTDG-TCEDLTGRCYCRPNFSGERCDV 460

  Fly   465 CARGY-------------QQSRSHIAP------------------CIKQP--PRMINMLDTQNTA 496
            ||.|:             ..:|..:.|                  |.|.|  .|.:...:.|.|.
Human   461 CAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTH 525

  Fly   497 PEPDEPE-----------SSPGSGGDR-NGAAGMAAQSQYYRTEGGRECGKCRVSTKRLNLNKFC 549
            .|...|.           ||||...|| :...|.......:.   |..|.:|........|.:.|
Human   526 CELCAPGFYGPGCQPCQCSSPGVADDRCDPDTGQCRCRVGFE---GATCDRCAPGYFHFPLCQLC 587

  Fly   550 KRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVADYEMDQVQPGSARSPITGVYEFQAADYPNPN 614
            ....|        .|..|... |..|....|:.|....|:.:||         |.    .:||..
Human   588 GCSPA--------GTLPEGCD-EAGRCLCQPEFAGPHCDRCRPG---------YH----GFPNCQ 630

  Fly   615 P---NPRGSEMERFDLQIQA-VFKRSRPGESSGA-----GNVYGMPNTT----LKRGPMTWIIPT 666
            .   :|||:    .|....| ...|.|||.:..|     ...:|.|:..    ...|.:......
Human   631 ACTCDPRGA----LDQLCGAGGLCRCRPGYTGTACQECSPGFHGFPSCVPCHCSAEGSLHAACDP 691

  Fly   667 KDLECRC-PRI 676
            :..:|.| ||:
Human   692 RSGQCSCRPRV 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	63/255 (25%)
		EGF_Lam	312..357	CDD:238012	22/48 (46%)
		EGF_Lam	369..426	CDD:238012	28/63 (44%)
		EGF_Lam	431..479	CDD:238012	14/78 (18%)
		NTR_netrin-1_like	545..723	CDD:239634	32/146 (22%)
LAMA5	XP_006723859.1	Laminin_N	54..298	CDD:278484	68/282 (24%)
		EGF_Lam	299..347	CDD:238012	22/48 (46%)
		EGF_Lam	358..421	CDD:238012	27/62 (44%)
		EGF_Lam	428..470	CDD:238012	12/42 (29%)
		EGF_Lam	494..541	CDD:214543	8/46 (17%)
		EGF_Lam	540..583	CDD:238012	10/45 (22%)
		Laminin_EGF	587..634	CDD:278482	14/68 (21%)
		Laminin_EGF	632..679	CDD:278482	12/50 (24%)
		EGF_Lam	676..718	CDD:238012	5/27 (19%)
		EGF_Lam	775..827	CDD:238012
		EGF_Lam	828..>867	CDD:238012
		Laminin_EGF	1438..1486	CDD:278482
		Laminin_EGF	1528..1579	CDD:278482
		Laminin_EGF	1577..1625	CDD:278482
		Laminin_B	1693..1818	CDD:278481
		Laminin_EGF	1864..1913	CDD:278482
		Laminin_EGF	1913..1966	CDD:278482
		EGF_Lam	1968..2021	CDD:238012
		EGF_Lam	2023..2067	CDD:214543
		EGF_Lam	2069..2115	CDD:238012
		Laminin_EGF	2117..>2145	CDD:278482
		Laminin_I	2188..2450	CDD:283627
		TorS_sensor_domain	2287..2578	CDD:293930
		PspA_IM30	2435..2695	CDD:281941
		Laminin_II	2641..2762	CDD:283628
		LamG	2781..2908	CDD:214598
		LamG	2943..3095	CDD:238058
		LamG	3124..3267	CDD:238058
		LamG	3345..3502	CDD:238058
		LamG	3526..3676	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910