Protein Alignment NetA and LAMA4

DIOPT Version :9

• Sequence 1: NP_001285243.1
• Gene: NetA / 32398
• FlyBaseID: FBgn0015773
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_001098676.2
• Gene: LAMA4 / 3910
• HGNCID: 6484
• Length: 1823
• Species: Homo sapiens
• Alignment Length: 395
• Identity: 90/395 - (22%)
• Similarity: 145/395 - (36%)
• Gaps: 93/395 - (23%)

  Fly   225 DLDSSPVL--QDWVTATDIRVVFHRLQRPDPQALLSLEA----------------GGATDLASGK 271
            |::.|..:  ||....::.||...||    |.|.....|                |.:.:...|.
Human    35 DIEGSSAVGRQDPPETSEPRVALGRL----PPAAEKCNAGFFHTLSGECVPCDCNGNSNECLDGS 95

  Fly   272 -YSVPLANGPAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKC-----NGHASKCSTDASGQL 330
             |.|.......|.:.|..|.|.:..|..|.......      |.|     ...|..|.. .:|.:
Human    96 GYCVHCQRNTTGEHCEKCLDGYIGDSIRGAPQFCQP------CPCPLPHLANFAESCYR-KNGAV 153

  Fly   331 NCECSHNTAGRDCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQGVSGGV 395
            .|.|:.|.||.:||||.|.::..|....:.     ||:|:|:.::..   |: ||.....|: |.
Human   154 RCICNENYAGPNCERCAPGYYGNPLLIGST-----CKKCDCSGNSDP---NL-IFEDCDEVT-GQ 208

  Fly   396 CQNCRHSTTGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKDGV--- 457
            |:||..:|||..|.:|..|:|.||    ...|.|..|:|     .|..|:|.:|:| .::|.
Human   209 CRNCLRNTTGFKCERCAPGYYGDA----RIAKNCAVCNC-----GGGPCDSVTGEC-LEEGFEPP 263

  Fly   458 TGLTCNRCARGYQQSRSHIAPCIKQPPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGMAAQS 522
            ||:.|               |.|.....:.::.|....|....|    .|..|..:.::|.||..
Human   264 TGMDC---------------PTISCDKCVWDLTDDLRLAALSIE----EGKSGVLSVSSGAAAHR 309

  Fly   523 QYYRTEGGRECGKCRVSTKRLNLNKFCKRDYAI-------------MAKVIGRDTSSEAVSREVQ 574
            ............|.::|.:.   |::..|...|             :.:::.::..:....:.||
Human   310 HVNEINATIYLLKTKLSERE---NQYALRKIQINNAENTMKSLLSDVEELVEKENQASRKGQLVQ 371

  Fly   575 RRAMD 579
            :.:||
Human   372 KESMD 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	15/73 (21%)
		EGF_Lam	312..357	CDD:238012	16/49 (33%)
		EGF_Lam	369..426	CDD:238012	19/56 (34%)
		EGF_Lam	431..479	CDD:238012	11/50 (22%)
		NTR_netrin-1_like	545..723	CDD:239634	7/48 (15%)
LAMA4	NP_001098676.2	EGF_Lam	81..130	CDD:238012	10/48 (21%)
		EGF_Lam	131..185	CDD:238012	16/65 (25%)
		EGF_Lam	187..238	CDD:238012	20/59 (34%)
		Laminin_I	296..554	CDD:283627	13/84 (15%)
		SPEC	339..531	CDD:295325	5/38 (13%)
		COG1340	426..724	CDD:224259
		Prefoldin	510..609	CDD:298833
		Laminin_II	734..861	CDD:283628
		LamG	835..1012	CDD:238058
		LamG	1049..1207	CDD:238058
		LamG	1237..1376	CDD:238058
		LamG	1492..1624	CDD:238058
		LamG	1648..1799	CDD:238058

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910