Protein Alignment NetA and LAMA2

DIOPT Version :9

• Sequence 1: NP_001285243.1
• Gene: NetA / 32398
• FlyBaseID: FBgn0015773
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: XP_016866340.1
• Gene: LAMA2 / 3908
• HGNCID: 6482
• Length: 3212
• Species: Homo sapiens
• Alignment Length: 683
• Identity: 178/683 - (26%)
• Similarity: 286/683 - (41%)
• Gaps: 141/683 - (20%)

  Fly    44 AHEPRA--CIPDFVNAAYDAPVVASSTCGSSGAQRYCEYQDH-------ERSCHTCDM--TDPLR 97
            |||.||  ..|..:|.|.:|.:..::|||..|.:.||:..:|       ...|..|:.  ::|.:
Human    33 AHELRARGLFPAVLNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPNQ 97

  Fly    98 SFPARSLTDLNNSNNVTCWRSEPVTGSGD--NVTLTLSLGKKFELTYVILQLCPHAPRPDSMVIY 160
            ..|..:..|..|    |.|:|..:....:  .||:||.|.:.|::.|||:: ..::|||.:.::.
Human    98 RHPITNAIDGKN----TWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVK-AANSPRPGNWILE 157

  Fly   161 KSTDHGLSWQPFQFFS---SQCRRLFG-RPARQSTGRHNEHEARCSDV---TRPLVS-RIAFSTL 217
            :|.| .:.::|:|:.:   ::|..|:. .|.........:.|..|:..   ..||.: .|..|.:
Human   158 RSLD-DVEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLI 221

  Fly   218 EGRPSSRDLDSSPVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLASGKYSVPLANGPAG 282
            .||||:.  |.||.|.::.:|..||:.|.|::        :|.|    ||....:..|....|
Human   222 NGRPSAD--DPSPELLEFTSARYIRLRFQRIR--------TLNA----DLMMFAHKDPREIDP-- 270

  Fly   283 NNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTD-ASGQLNCECSHNTAGRDCERC 346
                      :.|  ...:|::.|.||||.|.|.|||..|..| |:.:..|||.|||.|..|::|
Human   271 ----------IVT--RRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQC 323

  Fly   347 KPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLS-------QGVSGGVCQNCRHSTT 404
            .|....:||...|.....||:.|||:..|.:|.::..:.|.:       :.:.||||.||..:|.
Human   324 CPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTA 388

  Fly   405 GRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKIC---------NSTSGQCPCKDGVTGL 460
            |.||..|.:||:|.......:.:.|:.|.|.||||..::|         ....|.|.||.|..|:
Human   389 GINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGV 453

  Fly   461 TCNRCARGY----------------QQSRSHIAPCIKQPPRMINMLDTQNTAPEPDEPESSPGSG 509
            :|:||||||                :.......|||.:          :|.            .|
Human   454 SCDRCARGYTGYPDCKACNCSGLGSKNEDPCFGPCICK----------ENV------------EG 496

  Fly   510 GDRNGAAGMAAQSQYY--RTEGGRECGKCRVSTKRLNLNKFCKRDYAIMAKVIGRDTSSEAVSRE 572
            ||.:     ..:|.::  :.:..:.|.:|..|    .::..|:..|....|:  :|.|...::..
Human   497 GDCS-----RCKSGFFNLQEDNWKGCDECFCS----GVSNRCQSSYWTYGKI--QDMSGWYLTDL 550

  Fly   573 VQRRAMDPDVADYEMDQ---VQPGSARSPITGVYEFQA-ADY-PNPNPNPRGS---------EME 623
            ..|..:.|...|.:..|   :....||..:...|.:.| |.| .|..|...|.         |.|
Human   551 PGRIRVAPQQDDLDSPQQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGGQLTFTISYDLEEE 615

  Fly   624 RFD----LQIQAVFKRSRPGESSGAGNVYGMPN 652
            ..|    ||:..:.:.:....|:....||..|:
Human   616 EEDTERVLQLMIILEGNDLSISTAQDEVYLHPS 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	68/256 (27%)
		EGF_Lam	312..357	CDD:238012	20/45 (44%)
		EGF_Lam	369..426	CDD:238012	20/63 (32%)
		EGF_Lam	431..479	CDD:238012	20/72 (28%)
		NTR_netrin-1_like	545..723	CDD:239634	27/126 (21%)
LAMA2	XP_016866340.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910