DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetA and LanA

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_476617.1	Gene:	LanA / 38723	FlyBaseID:	FBgn0002526	Length:	3712	Species:	Drosophila melanogaster

Alignment Length:	640	Identity:	160/640 - (25%)
Similarity:	242/640 - (37%)	Gaps:	176/640 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PDFVNAAYDAPVVASSTCG--SSGAQRYCEY------QDH-------ERSCHTCDMTDPLRSFPA 101
            |.:.|.|....:.|::|||  :.|.:.||:.      .||       .:.|..||.|.|.|:.|.
  Fly    26 PPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYCDPTVPERNHPP 90

  Fly   102 RSLTDLNNSNNVTCWRSEPVT-GSGDN-VTLTLSLGKKFELTYVILQLCPHAPRPDSMVIYKSTD 164
            .:..|    .....|:|.|:: |...| |.||::..::|.:.|:.::: .::|||....:.||||
  Fly    91 ENAID----GTEAWWQSPPLSRGMKFNEVNLTINFEQEFHVAYLFIRM-GNSPRPGLWTLEKSTD 150

  Fly   165 HGLSWQPFQFFS---SQCRRLFGRPARQSTGRHNEHEARCSDVTRPLV----SRIAFSTLEGRPS 222
            :|.:|.|:|.||   :.|...||:...:...|  :.:..|:.....:|    ..|....|..|||
  Fly   151 YGKTWTPWQHFSDTPADCETYFGKDTYKPITR--DDDVICTTEYSKIVPLENGEIPVMLLNERPS 213

  Fly   223 SRDLDSSPVLQDWVTATDIRVVFHR----------LQRPDPQALLSLEAGGATDLASGKYSVPLA 277
            |.:..:|.|||:|..||::|:...|          :.|.||             ..:.:|
  Fly   214 STNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDP-------------TVTRRY----- 260

  Fly   278 NGPAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCST-DASGQ---LNCECSHNT 338
                                   .|:|.|.|:||||.|||||..|.. |....   |.|.|.|:|
  Fly   261 -----------------------FYSIKDISIGGRCMCNGHADTCDVKDPKSPVRILACRCQHHT 302

  Fly   339 AGRDCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQGVS---------GG 394
            .|..|..|.|....:.|.:.|......|:.|||:.|:.:|:::.|:.|  :|:|         ||
  Fly   303 CGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGHSNECKYDEEVNR--KGLSLDIHGHYDGGG 365

  Fly   395 VCQNCRHSTTGRNCHQCKEGFYRDATKPLTHRKV------------------------------- 428
            |||||:|:|.|.||::||..:||...|......|
  Fly   366 VCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPP 430

  Fly   429 --------------CKACDCHPIGSSGKICNSTSG-QCPCKDGVTGLTCNRCARGYQQSRSHIAP 478
                          |:.|:|:..|::|..|.:.|| |||||....|..|.:||.||.
  Fly   431 SCDSCAYGYYGYPNCRECECNLNGTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYY-------- 487

  Fly   479 CIKQPPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGMAAQSQYYRTEGGRECGKCRVSTKRL 543
                            ..||....|.:. .|...|.......:.:.....||..|.:|:......
  Fly   488 ----------------GFPECKACECNK-IGSITNDCNVTTGECKCLTNFGGDNCERCKHGYFNY 535

  Fly   544 NLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVADYEMDQVQPGSARSP 598
            ....:|..|        .:.|.||..:::..:............||..||....|
  Fly   536 PTCSYCDCD--------NQGTESEICNKQSGQCICREGFGGPRCDQCLPGFYNYP 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	68/261 (26%)
		EGF_Lam	312..357	CDD:238012	19/48 (40%)
		EGF_Lam	369..426	CDD:238012	26/65 (40%)
		EGF_Lam	431..479	CDD:238012	18/48 (38%)
		NTR_netrin-1_like	545..723	CDD:239634	10/54 (19%)
LanA	NP_476617.1	LamNT	18..271	CDD:214532	72/292 (25%)
		EGF_Lam	272..>314	CDD:238012	18/41 (44%)
		EGF_Lam	332..389	CDD:238012	24/58 (41%)
		EGF_Lam	402..443	CDD:238012	0/40 (0%)
		EGF_Lam	448..491	CDD:238012	18/66 (27%)
		Laminin_EGF	495..543	CDD:278482	8/48 (17%)
		Laminin_EGF	541..589	CDD:278482	10/50 (20%)
		Laminin_EGF	587..634	CDD:278482
		EGF_Lam	631..673	CDD:238012
		Laminin_EGF	677..729	CDD:278482
		Laminin_EGF	732..782	CDD:278482
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:278482
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:278482
		Laminin_EGF	1514..1562	CDD:278482
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:278482
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2129..2385	CDD:283627
		Tar	2278..2662	CDD:223910
		Laminin_II	2566..2700	CDD:283628
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445153
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940