Protein Alignment NetA and Megf8

DIOPT Version :10

• Sequence 1: NP_511154.3
• Gene: NetA / 32398
• FlyBaseID: FBgn0015773
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_609180.3
• Gene: Megf8 / 34099
• FlyBaseID: FBgn0031981
• Length: 2892
• Species: Drosophila melanogaster
• Alignment Length: 752
• Identity: 161/752 - (21%)
• Similarity: 241/752 - (32%)
• Gaps: 295/752 - (39%)

  Fly    10 LGTTRFSPIQCISNDVYFK--------------------MFSQQAPPEDP-----------CYNK 43
            |||     ::||:.::..|                    :...|.|.:|.           |...
  Fly  2062 LGT-----VECIAKELVEKNQYRVVESCPLPCHTYENCSLCLSQTPTQDHQECKWSTMLNLCLTP 2121

  Fly    44 AHEPRACIPDFVNAAYDAPVVASSTCG----SSGAQRYCEYQDHERSCHTCDMTDPLRSFPARSL 104
            :.:|..|              |...||    :|..||..|.......|.:|
  Fly  2122 SSQPLLC--------------AGGVCGLVLEASELQRCPEPCHVYTQCSSC-------------- 2158

  Fly   105 TDLNNSNNVTCWRSEPVTG-SGDNVTLTLSL--------GKKFELTYVILQLCPHAPRPDSMVIY 160
              |.:::...|.|.    | :||.:....:|        |...:|.|.       :.|.||.:.:
  Fly  2159 --LEHAHCGWCARE----GFNGDGICTEGALEHKQEHPSGSTCDLIYA-------SWRNDSQLTH 2210

  Fly   161 KSTDHGLSWQPFQFFSSQCRRLFGRPARQS--TGRHNEHEARCSDVTRPLVSRIAFSTLEGRPSS 223
            ...   :||.     ..||      ||...  .|.||     |..|:...:
  Fly  2211 ADV---VSWH-----YVQC------PAENECINGHHN-----CDTVSEQCI-------------- 2242

  Fly   224 RDLDSSPVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLASGKYSVPLANGPAGNNIEAN 288
             |||         ||...:.|..:..|.:..|.|.:.:.|..          ..|..:.:..:.:
  Fly  2243 -DLD---------TAVGYKCVCAQGYREEQGACLPVCSQGCV----------RGNCVSPDQCQCD 2287

  Fly   289 LGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTDASGQLNCECSHNTAGRDCERCKPFHFDR 353
            .|           |..::.|:  :|.|||| |.|.:.:...:..:|.:||.|..||:|:|.....
  Fly  2288 FG-----------YVGANCSI--QCLCNGH-SNCESSSRLDICLKCHNNTMGEQCEKCQPLFVGN 2338

  Fly   354 PWARATAKEANECKEC--NCNKHARQC--------RFNM---EIFR-LSQGVS-GGVCQNCRHST 403
            |      :|.:.|:.|  .|:.|:..|        .|||   |:.| |.:|.: ...|..|.:.|
  Fly  2339 P------REGHACQPCLDYCHGHSDVCVAYDADPAVFNMTRSELERILQEGPAYNATCLRCGNHT 2397

  Fly   404 TGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKDGVTGLTCNRCARG 468
            .|..|..|..|::| .::.|  .|.|:.|.||   ..|.||          |.|||..|| ||
  Fly  2398 AGDRCDSCLTGYFR-GSEDL--HKECRPCQCH---GHGNIC----------DPVTGEKCN-CA-- 2443

  Fly   469 YQQSRSHIAPCIKQPPRMINMLDTQNTAPEPDEPESSPGSGGDRNGA--AGMAAQSQYYRTEGGR 531
                                    .||     |.:::..:||.:|.|  ..|.
  Fly  2444 ------------------------NNT-----ESDATCTAGGGKNSAQLCWMV------------ 2467

  Fly   532 ECGKCRVS-----------TKRLNL-NKFCKRDYAIMAKVIGRDTSSEAVSRE-------VQRRA 577
            :|.|||.|           .|::.: ::.|     ..||.|....|..|..:.       :|.|.
  Fly  2468 QCSKCRDSYAGNPTDGHQCYKQITVESRMC-----FDAKPIEECKSKPAALKPGQTVFFVIQPRF 2527

  Fly   578 MDP------DVADYEMDQVQPGSARSPI------TGVYEFQAADYPNPNP-----NPRGSEMERF 625
            |:.      ||...|:|........|.|      ||.:|....:..|..|     :|....:.|.
  Fly  2528 MNVDIRIIIDVTQGELDVFMSPQDDSFIVETNETTGYHEIFLDNRYNWGPKIKREHPLNVALPRH 2592

  Fly   626 D-LQIQAVFKRSR----------PGESSGAGNVYGMP 651
            | :.||.:|...|          .||..|| |.|.:|
  Fly  2593 DNVTIQKLFSPERRIGGGGLGGGGGERIGA-NTYYVP 2628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_511154.3	LamNT	44..280	CDD:214532	46/250 (18%)
		EGF_Lam	312..357	CDD:238012	16/44 (36%)
		EGF_Lam	369..426	CDD:238012	20/71 (28%)
		EGF_Lam	431..479	CDD:238012	14/47 (30%)
		NTR_netrin-1_like	545..723	CDD:239634	34/143 (24%)
Megf8	NP_609180.3	CUB	33..141	CDD:238001
		NanM	<210..455	CDD:442289
		KELCH repeat	228..268	CDD:276965
		KELCH repeat	370..420	CDD:276965
		KELCH repeat	425..476	CDD:276965
		NanM	431..>630	CDD:442289
		KELCH repeat	480..540	CDD:276965
		EGF_3	1186..1222	CDD:463759
		EGF_Lam	1257..1302	CDD:238012
		EGF_Lam	1304..1354	CDD:238012
		KELCH repeat	1585..1638	CDD:276965
		NanM	1596..1892	CDD:442289
		KELCH repeat	1642..1685	CDD:276965
		KELCH repeat	1760..1813	CDD:276965
		KELCH repeat	1817..1867	CDD:276965
		EGF_Lam	2299..2346	CDD:238012	17/53 (32%)
		EGF_Lam	2422..2487	CDD:238012	27/121 (22%)