DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NetA and Megf9

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001101410.1	Gene:	Megf9 / 313270	RGDID:	1308330	Length:	599	Species:	Rattus norvegicus

Alignment Length:	414	Identity:	98/414 - (23%)
Similarity:	136/414 - (32%)	Gaps:	135/414 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 PHAPRPDSMVIYKSTDHGLSWQPFQFFSSQCRRLFGRPARQSTGRHNEHEARCSDVTRPLVSRIA 213
            |.|..|:::.:..|.....:..|....||            :|...:.|    :..|.||.||.|
  Rat    91 PSAGSPETIPVRTSAQPAATLFPVVDLSS------------ATPSEDGH----TPTTEPLPSRPA 139

  Fly   214 FSTL-------------------------------EGRPSSRDLDSSPVLQDWVTATDIRVVFHR 247
            .:||                               .||.|||...::||.:   ..|.
  Rat   140 PTTLASTAGQAPTTSVVTTAQASSTPGTPTAESPDRGRNSSRVPPTAPVTE---APTP------- 194

  Fly   248 LQRPDPQALLSLEAGGATDL------------------------ASGKY-------SVPLANGPA 281
               |.|:.:.:....|:.|:                        ..|.|       .:|....|.
  Rat   195 ---PPPEYMCNCSEVGSLDVKRCNQTTGQCDCHVGYQGLHCDTCKEGFYLNHTVGLCLPCHCSPR 256

  Fly   282 G---------NNIEANLG--GDVATSGSGLHYAISDFSVGG--RCKCNGHASKCSTDASGQLNCE 333
            |         .|.:..||  |.:.......||.   |...|  .|:||..:..|.......|||:
  Rat   257 GAVSILCNSSGNCQCKLGVTGSMCDQCQDGHYG---FGKTGCLPCQCNNRSDSCDVLTGACLNCQ 318

  Fly   334 CSHNTAGRDCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQN 398
              .||.|..||.||...:..|.|      |.||..|.|:.........:|.     |.....|..
  Rat   319 --ENTKGEHCEECKEGFYQSPDA------ARECLRCPCSAVTSTGNCTIEF-----GALEPTCDQ 370

  Fly   399 CRHSTTGRNCHQCKEGFYRDATKPLTHRKVCKACDCH----PIGSSGKICNSTSGQC-PCKDGVT 458
            |:...||:||:.|:.|:|...:       :|..|:||    || .:.|||...||:| .|....|
  Rat   371 CKDGYTGQNCNTCENGYYHSDS-------ICLQCECHGHVDPI-KTPKICKPESGECINCLHNTT 427

  Fly   459 GLTCNRCARGYQQSRSHIAPCIKQ 482
            ||.|.:|..||.:....  .||||
  Rat   428 GLWCEKCLEGYVRDLQR--NCIKQ 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	32/192 (17%)
		EGF_Lam	312..357	CDD:238012	15/44 (34%)
		EGF_Lam	369..426	CDD:238012	13/56 (23%)
		EGF_Lam	431..479	CDD:238012	19/52 (37%)
		NTR_netrin-1_like	545..723	CDD:239634
Megf9	NP_001101410.1	Baseplate_J	<54..>175	CDD:294789	17/99 (17%)
		Laminin_EGF	201..244	CDD:278482	4/42 (10%)
		Laminin_EGF	251..298	CDD:278482	10/49 (20%)
		EGF_Lam	297..343	CDD:238012	17/53 (32%)
		EGF_Lam	362..398	CDD:238012	11/42 (26%)
		Laminin_EGF	397..441	CDD:278482	19/44 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000