DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetA and Lamc3

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001101300.1	Gene:	Lamc3 / 311862	RGDID:	1309399	Length:	1580	Species:	Rattus norvegicus

Alignment Length:	811	Identity:	251/811 - (30%)
Similarity:	351/811 - (43%)	Gaps:	209/811 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 IRGILLLLLGTTRFSPIQCISNDVYFKMFSQQAPPEDPCYNKAHEPRACIPDFVNAAYDAPVVAS 66
            :.|||      :|.:.:.|::. |..|...........||:.|...:.|:|:|.|||:.....||
  Rat     3 VSGIL------SRLATVVCVAL-VMLKAHCATGAGMGSCYDGAGRAQRCLPEFENAAFGRRAEAS 60

  Fly    67 STCGSSGAQRYCEYQDHERS---CHTCDMTDPLRSFPARSLTDLNNSNNVTCWRSEPVTGSG--- 125
            .|||.. .:.:|.:.....:   |..||..||.|...|..|||.::.::.|.|:| |....|
  Rat    61 HTCGQP-PEDFCPHVGAPGAGPQCQRCDDADPRRRHDASYLTDFHSPDDSTWWQS-PSMAFGVQY 123

  Fly   126 -DNVTLTLSLGKKFELTYVILQLCPHAPRPDSMVIYKSTDHGLSWQPFQFFSSQCRRLFGRPARQ 189
             .:|.|||.|||.:|:|||.|:.  |..||:|..|||.|..|..|:|:|::|:.|::.:|.|
  Rat   124 PTSVNLTLHLGKAYEITYVRLKF--HTSRPESFAIYKRTHTGGPWEPYQYYSASCQKTYGHP--- 183

  Fly   190 STGRH-----NEHEARC----SDVTRPLVSRIAFSTLEGRPSSRDLDSSPVLQDWVTATDIRVVF 245
             .|.:     :|..|.|    ||::......:||||||||||:.:.:.|||||:|||:||:.:..
  Rat   184 -EGHYLRPGEDERVAFCTSEFSDISPLNGGNVAFSTLEGRPSAYNFEESPVLQEWVTSTDLLISL 247

  Fly   246 HRLQR------PDPQALLSLEAGGATDLASGKYSVPLANGPAGNNIEANLGGDVATSGSGLHYAI 304
            .||..      .||:.|.|                                         .:||:
  Rat   248 DRLNTFGDDIFKDPRVLQS-----------------------------------------YYYAV 271

  Fly   305 SDFSVGGRCKCNGHASKCSTDASGQLNCECSHNTAGRDCERCKPFHFDRPWARATAKEANECKEC 369
            ||||||||||||||||.|..:.:|||.|.|.|||.|.|||||.||..||||||.||::||||..|
  Rat   272 SDFSVGGRCKCNGHASACGPNEAGQLACHCQHNTTGVDCERCLPFFQDRPWARGTAEDANECLPC 336

  Fly   370 NCNKHARQCRFNMEIFRLSQGVSGGVCQNCRHSTTGRNCHQCKEGFYR-DATKPLTHRKVCKACD 433
            ||:.|:.:|.|:.|::| |.| .||.||.||..|.|.:|..|::.:|| |...|      |:.||
  Rat   337 NCSGHSEECTFDRELYR-STG-HGGHCQRCRDHTAGPHCEHCEKNYYRWDPKTP------CQPCD 393

  Fly   434 CHPIGSSGKICNSTSGQCPCKDGVTGLTCNRCARGYQQ-SRSHIAPCIKQPPRMINMLDTQNTAP 497
            |||.||....|:: ||.||||..|||..|:||..|:.. |.....||            |.|.|
  Rat   394 CHPAGSLSLQCDN-SGTCPCKLTVTGWKCDRCLPGFHSLSEGGCRPC------------TCNVA- 444

  Fly   498 EPDEPESSPGSGGDRNGAAGMAAQSQYYRTEGGRECGKCRVSTKRLNLNK-------FCKRDYAI 555
                     ||.|..:..:|.....:  ..|||. |.:||..|..|..:.       ||.....:
  Rat   445 ---------GSLGTCDPRSGNCPCKE--NVEGGL-CDRCRPGTFNLQPHNPAGCSSCFCYGHSKV 497

  Fly   556 MAKVIGRDTSS------------EAVSREVQRRAMD------------------PD--VADYEMD 588
            .|...|.....            :|.|.||..|.:.                  |:  :.|..:.
  Rat   498 CAPASGFQEHHIRSDFRHGADGWQARSTEVSERPLQWSQSGILLGLRGGEELSAPEKFLGDQRLS 562

  Fly   589 ---------QVQPGSARSPITGVYE---FQAADYPNPNPNPRGSEME-RFDLQ--IQAVFKRSRP 638
                     ||.||.:..|:....|   ...|..|:..|:.:.:... |..||  :|...:.:.|
  Rat   563 YGQPLILTLQVPPGGSPPPMQLRLEGAGLSLALKPSNLPSSQDTRQPGRVQLQFLLQETSEEAEP 627

  Fly   639 ----------------------GESSG-AGNV----YGMPNTTLKRG---PMTWIIPTKDLECRC 673
                                  |:..| :|:|    ..:.:...:||   |.:|:     ..|.|
  Rat   628 PLPAFHFQRLLSNLTTLSIWTSGQGLGHSGHVLLCEVHLTSARPQRGLAPPASWV-----ETCLC 687

  Fly   674 PRIRVNR--SYLILGRDSEAPPGYLGIGPHS 702
            |:....:  .:..||...|.|.|    ||::
  Rat   688 PQGYTGQFCEFCALGYKREIPHG----GPYT 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	88/257 (34%)
		EGF_Lam	312..357	CDD:238012	30/44 (68%)
		EGF_Lam	369..426	CDD:238012	24/57 (42%)
		EGF_Lam	431..479	CDD:238012	22/48 (46%)
		NTR_netrin-1_like	545..723	CDD:239634	43/244 (18%)
Lamc3	NP_001101300.1	Laminin_N	53..278	CDD:278484	88/273 (32%)
		EGF_Lam	279..326	CDD:238012	32/46 (70%)
		Laminin_EGF	336..392	CDD:278482	25/63 (40%)
		Laminin_EGF	392..439	CDD:278482	22/47 (47%)
		Laminin_EGF	439..486	CDD:278482	16/71 (23%)
		Laminin_B	550..671	CDD:278481	20/120 (17%)
		EGF_Lam	718..765	CDD:238012
		EGF_Lam	766..814	CDD:238012
		EGF_Lam	821..864	CDD:238012
		Laminin_EGF	878..925	CDD:278482
		Laminin_EGF	928..976	CDD:278482
		Laminin_EGF	976..>1013	CDD:278482
		Laminin_I	1183..1464	CDD:283627
		ATP-synt_B	<1211..1308	CDD:304375
		KASH_CCD	1387..1574	CDD:291334
		SPEC	<1407..1572	CDD:295325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910