DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetA and Ntn5

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	XP_017444633.2	Gene:	Ntn5 / 308587	RGDID:	1565197	Length:	516	Species:	Rattus norvegicus

Alignment Length:	697	Identity:	208/697 - (29%)
Similarity:	277/697 - (39%)	Gaps:	241/697 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DPCYNKAHEPRACIPDFVNAAYDAPVVASSTCGSSGAQRYCEYQDHERSCHTCDMTDPLRSFPAR 102
            ||||:....||.|:|........|....|.||                            :.||.
  Rat    32 DPCYDPGGRPRFCLPPVTQLVGKAAAPCSQTC----------------------------ALPAD 68

  Fly   103 SLTDLNNSNNVTCWRSEPVTGSGDNVTLTLSLGKKFELTYVILQLCPHAPRPDSMVIYKSTDHGL 167
            |              .:||.    |.||||.|...|.||.|.|:.|  ...|.::|:..:...|.
  Rat    69 S--------------PDPVC----NGTLTLDLDGSFLLTSVTLRFC--TAGPPALVLSAAWAIGG 113

  Fly   168 SWQPFQFFSSQCRRLFGRPARQSTGRHNEHEARCSDVTRPLVSRIAFSTLEGRPSSRDLDSSPVL 232
            .|                                    |||..|.|:..:.|.|.
  Rat   114 PW------------------------------------RPLWRRPAWPGVLGGPK---------- 132

  Fly   233 QDWVTATDIRVVFHRLQRPDPQ-----ALLSLEAGGATDLASGKYSVPLANGPAGNNIEANLGGD 292
                     :|.||  ..|.|:     :.|.:|.||...|
  Rat   133 ---------KVTFH--SPPGPKTRIVASYLRVELGGKAGL------------------------- 161

  Fly   293 VATSGSGLHYAISDFSVGGRCKCNGHASKCSTDASGQLNCECSHNTAGRDCERCKPFHFDRPWAR 357
             .|:|           |.|||:|:|||::|:..|... .|.|.|:|.|..||.|:|.|.|.||..
  Rat   162 -VTTG-----------VRGRCQCHGHAARCAARAQPP-RCRCRHHTTGPGCESCRPSHRDWPWRP 213

  Fly   358 ATAKEANECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNCRHSTTGRNCHQCKEGFYRDATKP 422
            ||.:..:.|..|:||:|||:||||.|:||||.|.|||||:.|||.|.||:||.|:.||:||.::|
  Rat   214 ATPQHPHPCLPCSCNQHARRCRFNSELFRLSGGRSGGVCERCRHHTAGRHCHYCQPGFWRDPSQP 278

  Fly   423 LTHRKVCKACDCHPIGSSGKICNSTSGQCPCKDGVTGLTCNRCARGYQQSRSHIAPCIKQPPRMI 487
            :|..|.|:||.|||||::|.:||.|||||.||.||||||||.|..|||||||...||.:.|..
  Rat   279 ITSPKACRACQCHPIGATGGMCNQTSGQCSCKLGVTGLTCNHCGPGYQQSRSPRMPCQRIPEA-- 341

  Fly   488 NMLDTQNTAPEPDEPESSPGSGGDRNGAAGMAAQSQYYRTEGGREC-GKCRVSTK--RLNLNKFC 549
                |...|..|....|.|                         :| |.|.||..  .:||.|:|
  Rat   342 ----TTALATTPVASRSDP-------------------------QCQGYCNVSVSSVHMNLQKYC 377

  Fly   550 KRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVADYEMDQVQPGSARSPITGVYEFQAADYPNPN 614
            ::||.:.|:|.                         |..||...|:.|.::...
  Rat   378 QQDYVLHARVA-------------------------ESAQVSASSSLSSLSEAV----------- 406

  Fly   615 PNPRGSEMERFDLQIQAVFK-RSRPGESSGAGNVYGMPNTTLKRGPMTWIIPTKDLECRCPRIRV 678
                |.|..|..:.:.|||| |:.|                ::||.....:|..||.|.|.|:|.
  Rat   407 ----GPEWWRLAVHVLAVFKQRAWP----------------VRRGSQEAWVPRADLSCGCLRLRP 451

  Fly   679 NRSYLILGRDSE--APPGYLGIGPHSIVIEWKEDWYRRMKRFQRRAR 723
            ...||:|||.:|  ..|.:|.:..||:.:.|:..|...::|.|::.|
  Rat   452 GADYLLLGRAAENHTDPAHLILNRHSLALPWRPRWAGPLRRLQQKER 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	46/240 (19%)
		EGF_Lam	312..357	CDD:238012	21/44 (48%)
		EGF_Lam	369..426	CDD:238012	36/56 (64%)
		EGF_Lam	431..479	CDD:238012	33/47 (70%)
		NTR_netrin-1_like	545..723	CDD:239634	44/180 (24%)
Ntn5	XP_017444633.2	Laminin_N	<77..>120	CDD:413488	18/80 (23%)
		EGF_Lam	169..213	CDD:238012	21/44 (48%)
		EGF_Lam	224..278	CDD:238012	34/53 (64%)
		EGF_Lam	287..336	CDD:238012	34/48 (71%)
		NTR_netrin-1_like	373..502	CDD:239634	45/182 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	65	1.000	Domainoid score	I9776
eggNOG	1	0.900	-	-		E1_KOG3512
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368755at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880