DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NetA and ntn1a

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_571104.1	Gene:	ntn1a / 30227	ZFINID:	ZDB-GENE-990415-169	Length:	603	Species:	Danio rerio

Alignment Length:	708	Identity:	313/708 - (44%)
Similarity:	412/708 - (58%)	Gaps:	153/708 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 MFSQQAPPEDPCYNKAHEPRACIPDFVNAAYDAPVVASSTCGSSGAQRYC----EYQDHERSCHT 89
            ||:.|..|.||||::...||.|||||||||:...|.||||||.: ..|||    :..:..|:|||
Zfish    29 MFAAQTSPPDPCYDENGHPRRCIPDFVNAAFGKEVRASSTCGKT-PSRYCVVTEKGDERHRNCHT 92

  Fly    90 CDMTDPLRSFPARSLTDLNNSNNVTCWRSEPVTGSGDNVTLTLSLGKKFELTYVILQLCPHAPRP 154
            ||.:||.::.|...||||||.:|:|||:|:.......|||||||||||||:|||.||.|  :|||
Zfish    93 CDASDPKKNHPPAYLTDLNNPHNLTCWQSDNYLQYPQNVTLTLSLGKKFEVTYVSLQFC--SPRP 155

  Fly   155 DSMVIYKSTDHGLSWQPFQFFSSQCRRLFGRPARQSTGRHNEHEARCSDV---TRPLV-SRIAFS 215
            :||.|:||.|:|.||.|||::|:|||:::.:|::.:..:.||.||.|:|.   ..||. ..||||
Zfish   156 ESMAIFKSMDYGKSWVPFQYYSTQCRKMYNKPSKATITKQNEQEAICTDSHTDMHPLSGGLIAFS 220

  Fly   216 TLEGRPSSRDLDSSPVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLASGKYSVPLANGP 280
            ||:||||:.|.|:|||||||||||||:|.|.||.      ....|....::||...|
Zfish   221 TLDGRPSAHDFDNSPVLQDWVTATDIKVTFSRLH------TFGDENEDDSELARDSY-------- 271

  Fly   281 AGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTDASGQLNCECSHNTAGRDCER 345
                                .||:||..||||||||||||:|..|..|.|.|||.|||||.:|:|
Zfish   272 --------------------FYAVSDLQVGGRCKCNGHASRCVKDRDGNLVCECKHNTAGPECDR 316

  Fly   346 CKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNCRHSTTGRNCHQ 410
            |||||:||||.||||:|||||..||||.|||:||||||:::||...|||||.||||:|.||:||.
Zfish   317 CKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHY 381

  Fly   411 CKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKDGVTGLTCNRCARGYQQSRSH 475
            ||||:|||.:||::|||.||||||||:|::||.||.|:|||||||||||:||||||.|||||||.
Zfish   382 CKEGYYRDMSKPISHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCANGYQQSRSP 446

  Fly   476 IAPCIK---QPPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGMAAQSQYYRTEGGRECGKCR 537
            ||||||   .||     ..|.::..||.:.||                   |.:...|:
Zfish   447 IAPCIKIPIAPP-----TTTASSTEEPSDCES-------------------YCKASKGK------ 481

  Fly   538 VSTKRLNLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVADYEMDQVQPGSARSPITGV 602
               .::|:.|:||:|||:...::..|
Zfish   482 ---LKINMKKYCKKDYAVQVHILKAD--------------------------------------- 504

  Fly   603 YEFQAADYPNPNPNPRGSEMERFDLQIQAVFKRSRPGESSGAGNVYGMPNTTLKRGPMTWIIPTK 667
                           :..|..:|.:.|.:|:|:   |||            .::||.....:..|
Zfish   505 ---------------KAGEWWKFTVNIISVYKQ---GES------------RIRRGDQFLWVRAK 539

  Fly   668 DLECRCPRIRVNRSYLILGRDSEAPPGYLGI--GPHSIVIEWKEDWYRRMKRFQRRAR 723
            |:.|:||:|:..:.||:||.|.:: ||..|:  ...|:||:|::.|.||:::||:|.:
Zfish   540 DVACKCPKIKSGKKYLLLGNDEDS-PGQSGMVADKGSLVIQWRDTWARRLRKFQQREK 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	121/243 (50%)
		EGF_Lam	312..357	CDD:238012	32/44 (73%)
		EGF_Lam	369..426	CDD:238012	38/56 (68%)
		EGF_Lam	431..479	CDD:238012	38/47 (81%)
		NTR_netrin-1_like	545..723	CDD:239634	41/179 (23%)
ntn1a	NP_571104.1	LamNT	45..282	CDD:214532	126/273 (46%)
		EGF_Lam	283..328	CDD:238012	32/44 (73%)
		Laminin_EGF	340..393	CDD:278482	36/52 (69%)
		EGF_Lam	402..450	CDD:238012	38/47 (81%)
		NTR_netrin-1_like	486..600	CDD:239634	41/181 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580913
Domainoid	1	1.000	228	1.000	Domainoid score	I2420
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	631	1.000	Inparanoid score	I821
OMA	1	1.010	-	-		QHG48023
OrthoDB	1	1.010	-	-		D368755at33208
OrthoFinder	1	1.000	-	-		FOG0003523
OrthoInspector	1	1.000	-	-		otm24307
orthoMCL	1	0.900	-	-		OOG6_104609
Panther	1	1.100	-	-	LDO	PTHR10574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1381
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910