Protein Alignment NetA and ntn1b

DIOPT Version :10

• Sequence 1: NP_511154.3
• Gene: NetA / 32398
• FlyBaseID: FBgn0015773
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_571073.1
• Gene: ntn1b / 30192
• ZFINID: ZDB-GENE-990415-168
• Length: 602
• Species: Danio rerio
• Alignment Length: 712
• Identity: 306/712 - (42%)
• Similarity: 401/712 - (56%)
• Gaps: 163/712 - (22%)

  Fly    29 MFSQQAPPEDPCYNKAHEPRACIPDFVNAAYDAPVVASSTCGSSGAQRYCEY----QDHERSCHT 89
            ||:.|:.|.||||::...||.|||||||:|:...|..||||||. ..|.|..    ::..|.|:.
Zfish    29 MFAAQSSPPDPCYDENGNPRRCIPDFVNSAFGKDVRVSSTCGSP-PSRCCRVTEKGEERSRDCNI 92

  Fly    90 CDMTDPLRSFPARSLTDLNNSNNVTCWRSEPVTGSGDNVTLTLSLGKKFELTYVILQLCPHAPRP 154
            ||.|||.::.|...||||||.:|:|||:||.......|||||||||||||:|||.||.|  :|||
Zfish    93 CDATDPKKTHPPAYLTDLNNPHNLTCWQSENYVQYPQNVTLTLSLGKKFEVTYVSLQFC--SPRP 155

  Fly   155 DSMVIYKSTDHGLSWQPFQFFSSQCRRLFGRPARQSTGRHNEHEARCSDV---TRPLV-SRIAFS 215
            :||.|:||.|:|.:|.||||:|:||::::.:|::.:..:.||.||.|:|.   .:||. ..||||
Zfish   156 ESMAIFKSMDYGKTWVPFQFYSTQCKKMYNKPSKAAITKQNEQEAICTDSHTDMQPLTGGLIAFS 220

  Fly   216 TLEGRPSSRDLDSSPVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLASGKYSVPLANGP 280
            ||:||||:.|.|:|||||||||||||:|.|:||.      ....|....::||...|
Zfish   221 TLDGRPSAHDFDNSPVLQDWVTATDIKVTFNRLH------TFGDENEDDSELARDSY-------- 271

  Fly   281 AGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTDASGQLNCECSHNTAGRDCER 345
                                .||:||..||||||||||||||..|..|.|.|||.|||||.:|:|
Zfish   272 --------------------FYAVSDLQVGGRCKCNGHASKCVKDREGNLVCECKHNTAGPECDR 316

  Fly   346 CKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNCRHSTTGRNCHQ 410
            |||||:||||.||||:|||||..|:||.|||:||||||:::||...|||||.||||:|.||:||.
Zfish   317 CKPFHYDRPWQRATAREANECVACHCNLHARRCRFNMELYKLSGRRSGGVCLNCRHNTAGRHCHY 381

  Fly   411 CKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKDGVTGLTCNRCARGYQQSRSH 475
            ||||:|||.:|.::||:.||||||||:|::||.||.|:|||||||||||:||||||:|||||||.
Zfish   382 CKEGYYRDMSKAISHRRACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSP 446

  Fly   476 IAPCIKQPPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGMAAQSQYYRTEGGREC------- 533
            ||||||.|            ...|....|||                     :|..:|
Zfish   447 IAPCIKIP------------VAAPTSSYSSP---------------------DGPTDCDSHCKAP 478

  Fly   534 -GKCRVSTKRLNLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVADYEMDQVQPGSARS 597
             ||.:|:.|     |:||:|:|:...|:..|
Zfish   479 KGKMKVTMK-----KYCKKDFAVQVHVLKGD---------------------------------- 504

  Fly   598 PITGVYEFQAADYPNPNPNPRGSEMERFDLQIQAVFKRSRPGESSGAGNVYGMPNTTLKRGPMTW 662
                                :..|..:|.:.|.:|:|:.               ...::||....
Zfish   505 --------------------KAGEWWKFTINIISVYKQG---------------GHRIRRGDQLL 534

  Fly   663 IIPTKDLECRCPRIRVNRSYLILGRDSEAPP-GYLGI--GPHSIVIEWKEDWYRRMKRFQRR 721
            .:..||:.|:||:|:..|.||::|.|.|... |..|:  ...|::|.||:.|.||:::||:|
Zfish   535 WVRAKDVACKCPKIKPGRKYLLMGSDEEEDSRGQSGVVADRGSLLIPWKDLWARRLRKFQQR 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_511154.3	LamNT	44..280	CDD:214532	118/243 (49%)
		EGF_Lam	312..357	CDD:238012	33/44 (75%)
		EGF_Lam	369..426	CDD:238012	36/56 (64%)
		EGF_Lam	431..479	CDD:238012	38/47 (81%)
		NTR_netrin-1_like	545..723	CDD:239634	38/180 (21%)
ntn1b	NP_571073.1	LamNT	45..282	CDD:214532	123/273 (45%)
		EGF_Lam	283..328	CDD:238012	33/44 (75%)
		Laminin_EGF	340..389	CDD:395007	33/48 (69%)
		EGF_Lam	402..450	CDD:238012	38/47 (81%)
		NTR_netrin-1_like	486..602	CDD:239634	39/185 (21%)