DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetA and Ntn4

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001100250.1	Gene:	Ntn4 / 299737	RGDID:	1565947	Length:	630	Species:	Rattus norvegicus

Alignment Length:	730	Identity:	188/730 - (25%)
Similarity:	288/730 - (39%)	Gaps:	192/730 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 RACIPDFVNAAYDAPVVASSTCGSSGAQRYCEYQDH------ERSCHTCDMTDPLRSFPARSLTD 106
            :||.|...|.|....:.|.:|||.:..:.:|.|.::      :..|..|:......:.|..::.|
  Rat    32 KACNPRMGNLALGRKLQADTTCGQNATELFCFYSENADLTCRQPKCDKCNGAHSHLAHPPSAMAD 96

  Fly   107 LNNSNNVTCWRS-EPVTGSGDNVTLTLSLGKKFELTYVILQLCPHAPRPDSMVIYKSTDHGLSWQ 170
            .:.....|.|:| |.|    ....:.|.|..:|..|::|:..  .:|||.:||:.:|.|.|.:|:
  Rat    97 SSFRFPRTWWQSAEDV----HREKIQLDLEAEFYFTHLIMVF--KSPRPAAMVLDRSQDFGKTWK 155

  Fly   171 PFQFFSSQCRRLFG------RPARQSTGRHNEHEARCSDVTRPLVSRIAFSTLEGRPSSRDLDSS 229
            |:::|::.|...||      :.....|.|:: :...|:.      ..:.|..| ..|...:...|
  Rat   156 PYKYFATNCSATFGLEDDVVKKGAICTSRYS-NPFPCTG------GEVIFRAL-SPPYDIENPYS 212

  Fly   230 PVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLASGKYSVPLANGPAGNNIEANLGGDVA 294
            ..:|:.:..|::||   ||.:                    :.|.|...    |::.|.
  Rat   213 AKVQEQLKITNLRV---RLLK--------------------RQSCPCQR----NDLNAK------ 244

  Fly   295 TSGSGLHYAISDFSVGGRCKCNGHASKC-------STDASGQLN-----CECSHNTAGRDCERCK 347
             .....||||.||.|.|.|.|||||.:|       ...|.|..:     |.|.|||||..|:.|.
  Rat   245 -PHHFTHYAIYDFIVKGSCFCNGHADQCLPVEGFRPVKAPGAFHVVHGKCMCKHNTAGSHCQHCA 308

  Fly   348 PFHFDRPWARATAKEA--NECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNCRHSTTGRNCHQ 410
            |.:.||||..|..:..  |||:.|.||.||..|.|::.::..|...|||||.||:|:|.|::|.:
  Rat   309 PLYNDRPWEAADGRTGAPNECRTCKCNGHADTCHFDINVWEASGNRSGGVCNNCQHNTEGQHCQR 373

  Fly   411 CKEGFYRDATKPLTHRKVCKACDCHPIG------SSGKICNSTSGQCPCKDGVTGLTCNRCARGY 469
            ||.|||||..:|.:....||||.|||:|      ||...|:.::|.||||.||.|..|:||..||
  Rat   374 CKPGFYRDLRRPFSAPDACKACSCHPVGSAILPFSSVTFCDPSNGDCPCKPGVAGPHCDRCMVGY 438

  Fly   470 QQSRSH-IAPCIKQPPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGM-------AAQSQYYR 526
            .....: ..||           |...:.        .|.:|...:..|.:       |..|.:.:
  Rat   439 WGFGDYGCRPC-----------DCAGSC--------DPLTGDCISSNADVDWYHEVPAFHSLHNK 484

  Fly   527 TEGG------------RECGKCRVSTKRL-NLNKFC--KRDYAIMAKVIGRDTSSEAVSREVQRR 576
            :|.|            |..|||....:.| |...||  |..|.:..|::
  Rat   485 SEPGWEWEDEQGFSALRHSGKCECKEQVLGNPKAFCGMKYSYVLKIKIL---------------- 533

  Fly   577 AMDPDVADYEMDQVQPGSARSPITGVYEFQAADYPNPNPNPRGSEMERFDLQIQAVFKRSRPGES 641
                                                 :.:.:||..| .:::|:.|.:.::....
  Rat   534 -------------------------------------SAHDKGSHAE-VNVKIKKVLQATKLKIL 560

  Fly   642 SGAGNVYGMPNTTLKRGPMTWIIPTKDLECRCPRIRVNRSYLILGRDSEAPPGYLGIGPHSIVIE 706
            .|...:|  |.:...||            |.||.:.....||:.|.: :...|.|.:...|.|..
  Rat   561 RGKRTLY--PESWTNRG------------CTCPILNPGLEYLVAGYE-DVRTGRLIVNMKSFVQP 610

  Fly   707 WKEDWYRRMKRFQRR 721
            ||....||:....:|
  Rat   611 WKPALGRRVMHILKR 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	54/244 (22%)
		EGF_Lam	312..357	CDD:238012	23/56 (41%)
		EGF_Lam	369..426	CDD:238012	27/56 (48%)
		EGF_Lam	431..479	CDD:238012	22/54 (41%)
		NTR_netrin-1_like	545..723	CDD:239634	30/179 (17%)
Ntn4	NP_001100250.1	Laminin_N	43..260	CDD:278484	58/264 (22%)
		EGF_Lam	261..320	CDD:238012	23/58 (40%)
		Laminin_EGF	332..392	CDD:278482	27/59 (46%)
		Laminin_EGF	395..449	CDD:278482	21/53 (40%)
		NTR_netrin-4_like	517..626	CDD:239633	30/178 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910