Protein Alignment NetA and Ntn4

DIOPT Version :10

• Sequence 1: NP_511154.3
• Gene: NetA / 32398
• FlyBaseID: FBgn0015773
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_001100250.1
• Gene: Ntn4 / 299737
• RGDID: 1565947
• Length: 630
• Species: Rattus norvegicus
• Alignment Length: 730
• Identity: 188/730 - (25%)
• Similarity: 288/730 - (39%)
• Gaps: 192/730 - (26%)

  Fly    48 RACIPDFVNAAYDAPVVASSTCGSSGAQRYCEYQDH------ERSCHTCDMTDPLRSFPARSLTD 106
            :||.|...|.|....:.|.:|||.:..:.:|.|.::      :..|..|:......:.|..::.|
  Rat    32 KACNPRMGNLALGRKLQADTTCGQNATELFCFYSENADLTCRQPKCDKCNGAHSHLAHPPSAMAD 96

  Fly   107 LNNSNNVTCWRS-EPVTGSGDNVTLTLSLGKKFELTYVILQLCPHAPRPDSMVIYKSTDHGLSWQ 170
            .:.....|.|:| |.|    ....:.|.|..:|..|::|:..  .:|||.:||:.:|.|.|.:|:
  Rat    97 SSFRFPRTWWQSAEDV----HREKIQLDLEAEFYFTHLIMVF--KSPRPAAMVLDRSQDFGKTWK 155

  Fly   171 PFQFFSSQCRRLFG------RPARQSTGRHNEHEARCSDVTRPLVSRIAFSTLEGRPSSRDLDSS 229
            |:::|::.|...||      :.....|.|:: :...|:.      ..:.|..| ..|...:...|
  Rat   156 PYKYFATNCSATFGLEDDVVKKGAICTSRYS-NPFPCTG------GEVIFRAL-SPPYDIENPYS 212

  Fly   230 PVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLASGKYSVPLANGPAGNNIEANLGGDVA 294
            ..:|:.:..|::||   ||.:                    :.|.|...    |::.|.
  Rat   213 AKVQEQLKITNLRV---RLLK--------------------RQSCPCQR----NDLNAK------ 244

  Fly   295 TSGSGLHYAISDFSVGGRCKCNGHASKC-------STDASGQLN-----CECSHNTAGRDCERCK 347
             .....||||.||.|.|.|.|||||.:|       ...|.|..:     |.|.|||||..|:.|.
  Rat   245 -PHHFTHYAIYDFIVKGSCFCNGHADQCLPVEGFRPVKAPGAFHVVHGKCMCKHNTAGSHCQHCA 308

  Fly   348 PFHFDRPWARATAKEA--NECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNCRHSTTGRNCHQ 410
            |.:.||||..|..:..  |||:.|.||.||..|.|::.::..|...|||||.||:|:|.|::|.:
  Rat   309 PLYNDRPWEAADGRTGAPNECRTCKCNGHADTCHFDINVWEASGNRSGGVCNNCQHNTEGQHCQR 373

  Fly   411 CKEGFYRDATKPLTHRKVCKACDCHPIG------SSGKICNSTSGQCPCKDGVTGLTCNRCARGY 469
            ||.|||||..:|.:....||||.|||:|      ||...|:.::|.||||.||.|..|:||..||
  Rat   374 CKPGFYRDLRRPFSAPDACKACSCHPVGSAILPFSSVTFCDPSNGDCPCKPGVAGPHCDRCMVGY 438

  Fly   470 QQSRSH-IAPCIKQPPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGM-------AAQSQYYR 526
            .....: ..||           |...:.        .|.:|...:..|.:       |..|.:.:
  Rat   439 WGFGDYGCRPC-----------DCAGSC--------DPLTGDCISSNADVDWYHEVPAFHSLHNK 484

  Fly   527 TEGG------------RECGKCRVSTKRL-NLNKFC--KRDYAIMAKVIGRDTSSEAVSREVQRR 576
            :|.|            |..|||....:.| |...||  |..|.:..|::
  Rat   485 SEPGWEWEDEQGFSALRHSGKCECKEQVLGNPKAFCGMKYSYVLKIKIL---------------- 533

  Fly   577 AMDPDVADYEMDQVQPGSARSPITGVYEFQAADYPNPNPNPRGSEMERFDLQIQAVFKRSRPGES 641
                                                 :.:.:||..| .:::|:.|.:.::....
  Rat   534 -------------------------------------SAHDKGSHAE-VNVKIKKVLQATKLKIL 560

  Fly   642 SGAGNVYGMPNTTLKRGPMTWIIPTKDLECRCPRIRVNRSYLILGRDSEAPPGYLGIGPHSIVIE 706
            .|...:|  |.:...||            |.||.:.....||:.|.: :...|.|.:...|.|..
  Rat   561 RGKRTLY--PESWTNRG------------CTCPILNPGLEYLVAGYE-DVRTGRLIVNMKSFVQP 610

  Fly   707 WKEDWYRRMKRFQRR 721
            ||....||:....:|
  Rat   611 WKPALGRRVMHILKR 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_511154.3	LamNT	44..280	CDD:214532	54/244 (22%)
		EGF_Lam	312..357	CDD:238012	23/56 (41%)
		EGF_Lam	369..426	CDD:238012	27/56 (48%)
		EGF_Lam	431..479	CDD:238012	22/54 (41%)
		NTR_netrin-1_like	545..723	CDD:239634	30/179 (17%)
Ntn4	NP_001100250.1	Laminin_N	34..260	CDD:459653	62/273 (23%)
		EGF_Lam	261..320	CDD:238012	23/58 (40%)
		Laminin_EGF	332..392	CDD:395007	27/59 (46%)
		EGF_Lam	395..446	CDD:214543	21/50 (42%)
		NTR_netrin-4_like	517..626	CDD:239633	30/178 (17%)