DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetA and lamc1

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_775384.1	Gene:	lamc1 / 286832	ZFINID:	ZDB-GENE-021226-3	Length:	1593	Species:	Danio rerio

Alignment Length:	790	Identity:	240/790 - (30%)
Similarity:	341/790 - (43%)	Gaps:	208/790 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DPCYNKAHEPRACIPDFVNAAYDAPVVASSTCGSSGAQRYC---EYQDHERSCHTCDMTDPLRSF 99
            |.|.::...|:.|:|:|||||::|.|||::||||. .:.:|   ......:|||.|:..||....
Zfish    22 DECIDEDDRPQRCMPEFVNAAFNATVVATNTCGSP-PEEFCVQTGVTGVTKSCHICNAADPRLHH 85

  Fly   100 PARSLTDLNNSNNVTCWRSEPVTGS---GDNVTLTLSLGKKFELTYVILQLCPHAPRPDSMVIYK 161
            .|..|||.|.....|.|:|:.:...   .:::.|||.|||.|::|||.|:.  |..||:|..|||
Zfish    86 GAVYLTDYNQPVQPTWWQSQTMLAGIQYPNSINLTLHLGKSFDITYVRLKF--HTSRPESFAIYK 148

  Fly   162 STDHGLSWQPFQFFSSQCRRLFGRPARQ--STGRHNEHEARC----SDVTRPLVSRIAFSTLEGR 220
            .:.....|.|:|::|..|.:.:.:..|.  .|| .:|.:|.|    ||::......:||||||||
Zfish   149 RSSEDGPWTPYQYYSGSCEKTYSKNNRGFIRTG-EDEQQALCTDEFSDISPLYGGNVAFSTLEGR 212

  Fly   221 PSSRDLDSSPVLQDWVTATDIRVVFHRLQR------PDPQALLSLEAGGATDLASGKYSVPLANG 279
            ||:.:.|:|||||||||||||||..:||..      .||:.|.|
Zfish   213 PSAYNFDNSPVLQDWVTATDIRVTLNRLNTFGDEVFNDPKVLKS--------------------- 256

  Fly   280 PAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTDASGQLNCECSHNTAGRDCE 344
                                .:||||||:||||||||||||:|..:...:|.|.|.|||.|.||.
Zfish   257 --------------------YYYAISDFAVGGRCKCNGHASECVKNEYSKLVCNCKHNTEGADCN 301

  Fly   345 RCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNCRHSTTGRNCH 409
            .||||:.||||.||||:..|||..||||..:.:|.|:.|::|.:.  .||.|:||..:|.|..|.
Zfish   302 VCKPFYNDRPWRRATAENPNECLPCNCNGKSAECYFDPELYRATG--HGGHCRNCADNTDGPKCE 364

  Fly   410 QCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKDGVTGLTCNRCARGYQQ-SR 473
            :|...:||:|:     .:.|.:|.|:|:||....|::| |:|.||.||.|..|:||..||.. |.
Zfish   365 RCLANYYREAS-----GQRCLSCGCNPVGSLSTQCDNT-GRCSCKPGVMGDKCDRCQPGYHSLSE 423

  Fly   474 SHIAPCIKQPPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGMAAQSQYYRTEGGRECGKCRV 538
            :...||...|.......|.|                         ..:.|......|..|.:|::
Zfish   424 AGCRPCSCNPAGSTQECDVQ-------------------------TGRCQCKENVDGFNCDRCKL 463

  Fly   539 STKRLNLNK-------FCKRDYAIMAKVIG---------------------RDTSSEAV-----S 570
            ....|:...       ||.:...:.....|                     ||.||..|     |
Zfish   464 GYFNLDPQNPQGCTPCFCFQHSTVCESADGYSVHKITSTFDRDDEGWKGKQRDDSSVPVQWSPSS 528

  Fly   571 REVQRRAMD--------PD------VADYEMD-----QVQPGSAR----------------SPI- 599
            .|:...:.|        ||      :..|..:     ::|...||                .|:
Zfish   529 GEISLISEDYFPIYFVAPDKFLHNQLLSYGQNLTLNFRIQRHDARLSAEDVVLEGSGLRVAVPLI 593

  Fly   600 ----------TGVYEFQ---AADYPNPNPNPRGSEMERFDLQIQAVFKRSRPGESSGAGNVYGMP 651
                      |..:.|:   ..||| ..|..:.::.::....:.::..|......| ||.:..:.
Zfish   594 AQGNSYPGEETQTFVFRLHDTTDYP-WRPTIKHADFQKLLYNLTSIMIRGTYSAQS-AGYLDNVS 656

  Fly   652 NTTLKRGPMTWIIPTKDLE-CRCPRIRVNRSYLILGRDSEAPPGYLGIGPHSIVIEWKEDWYRRM 715
            ..|.:|||.|   |.:.:| |.||:                  |||  |.|   .|..:..:||.
Zfish   657 LVTARRGPGT---PARWVEKCTCPQ------------------GYL--GQH---CEQCDQGFRRS 695

  Fly   716 KRFQRRARTC 725
            :...||..||
Zfish   696 RPELRRFSTC 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	94/253 (37%)
		EGF_Lam	312..357	CDD:238012	27/44 (61%)
		EGF_Lam	369..426	CDD:238012	20/56 (36%)
		EGF_Lam	431..479	CDD:238012	20/48 (42%)
		NTR_netrin-1_like	545..723	CDD:239634	48/260 (18%)
lamc1	NP_775384.1	LamNT	30..268	CDD:214532	101/282 (36%)
		EGF_Lam	269..314	CDD:238012	27/44 (61%)
		Laminin_EGF	326..379	CDD:278482	20/59 (34%)
		Laminin_EGF	382..429	CDD:278482	20/47 (43%)
		Laminin_EGF	429..476	CDD:278482	9/71 (13%)
		Laminin_B	537..662	CDD:295357	19/126 (15%)
		EGF_Lam	707..749	CDD:238012
		Laminin_EGF	812..856	CDD:278482
		EGF_Lam	867..917	CDD:238012
		EGF_Lam	919..964	CDD:214543
		Laminin_EGF	967..1013	CDD:278482
		Domain II and I. /evidence=ECO:0000250	1014..1593
		SPEC	1033..1233	CDD:295325
		Taxilin	1035..1308	CDD:286771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	3	2.870