DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NetA and Ntn5

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	XP_006540948.1	Gene:	Ntn5 / 243967	MGIID:	2685330	Length:	523	Species:	Mus musculus

Alignment Length:	725	Identity:	211/725 - (29%)
Similarity:	290/725 - (40%)	Gaps:	245/725 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GTTRFSPIQCISNDVYFKMFSQQAPPEDPCYNKAHEPRACIPDFVNAAYDAPVVASSTCGSSGAQ 75
            |:|..:||     .:...:...|| ..||||:....||.|:|........|....|.||
Mouse    14 GSTVTTPI-----TLSLLLLLSQA-TSDPCYDPGGRPRFCLPPVTQLVGKAAAPCSQTC------ 66

  Fly    76 RYCEYQDHERSCHTCDMTDPLRSFPARSLTDLNNSNNVTCWRSEPVTGSGDNVTLTLSLGKKFEL 140
                                  :.||.|                  .|...|.:|||.|...|.|
Mouse    67 ----------------------ALPAAS------------------PGPACNSSLTLDLDGSFLL 91

  Fly   141 TYVILQLCPHAPRPDSMVIYKSTDHGLSWQPFQFFSSQCRRLFGRPARQSTGRHNEHEARCSDVT 205
            |.|.|:.|  ...|.::|:..:...|..|
Mouse    92 TSVTLRFC--TAGPPALVLSAAWATGGPW------------------------------------ 118

  Fly   206 RPLVSRIAFSTLEGRPSSRDLDSSPVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLASG 270
            |||..|.|:....|.|......|.|..:..:.|:.:||.|
Mouse   119 RPLWRRPAWPGALGGPKKVTFHSPPGPKTRIVASYLRVEF------------------------- 158

  Fly   271 KYSVPLANGPAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTDASGQLNCECS 335
                   .|.||          :.|:|           |.|||:|:|||::|:|.|... .|.|.
Mouse   159 -------GGKAG----------LVTTG-----------VRGRCQCHGHAARCATRAQPP-RCRCR 194

  Fly   336 HNTAGRDCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNCR 400
            |:|.|..||.|:|.|.|.||..||.:..:.|..|:||:|||:||||.|:||||.|.|||||:.||
Mouse   195 HHTTGPGCESCRPSHRDWPWRPATPQHPHPCLPCSCNQHARRCRFNSELFRLSGGRSGGVCERCR 259

  Fly   401 HSTTGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKDGVTGLTCNRC 465
            |.|.||:||.|:.||:||.::|:|..|.|:||.|||||::|.:||.|||||.||.||||||||||
Mouse   260 HHTAGRHCHYCQPGFWRDPSQPITSHKACRACQCHPIGATGGMCNQTSGQCSCKLGVTGLTCNRC 324

  Fly   466 ARGYQQSRSHIAPCIKQPPRMINMLDTQNTAPE-PDEPESSPGSGGDRNGAAGMAAQSQYYRTEG 529
            ..|||||||...||.::      ...|::..|| ...|.::|           :|::|.
Mouse   325 GPGYQQSRSPRMPCQRE------SYGTRSRIPEATTTPATTP-----------VASRSD------ 366

  Fly   530 GREC-GKCRVSTK--RLNLNKFCKRDYAIMAKVIGRDTS-SEAVSREVQRRAMDPDVADYEMDQV 590
             .:| |.|.||..  .::|.::|::||.:.|:|....:. ||||
Mouse   367 -PQCQGYCNVSVSSVHMSLQRYCQQDYVLHAQVSASSSQPSEAV--------------------- 409

  Fly   591 QPGSARSPITGVYEFQAADYPNPNPNPRGSEMERFDLQIQAVFK-RSRPGESSGAGNVYGMPNTT 654
                                        |.|..|..:.:.|||| |:.|
Mouse   410 ----------------------------GPEWWRLAVHVLAVFKQRAWP---------------- 430

  Fly   655 LKRGPMTWIIPTKDLECRCPRIRVNRSYLILGR------DSEAPPGYLGIGPHSIVIEWKEDWYR 713
            ::||.....:|..||.|.|.|:|....||:|||      |....|..|.:..|.:.:.|:..|.|
Mouse   431 VRRGGQEAWVPRADLICGCLRLRPGADYLLLGRAAQTHDDDNYDPARLILNRHGLALPWRPRWAR 495

  Fly   714 RMKRFQRRAR 723
            .::|.|::.|
Mouse   496 PLRRLQQKER 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	40/235 (17%)
		EGF_Lam	312..357	CDD:238012	22/44 (50%)
		EGF_Lam	369..426	CDD:238012	36/56 (64%)
		EGF_Lam	431..479	CDD:238012	34/47 (72%)
		NTR_netrin-1_like	545..723	CDD:239634	42/185 (23%)
Ntn5	XP_006540948.1	EGF_Lam	172..216	CDD:238012	22/44 (50%)
		EGF_Lam	227..281	CDD:238012	34/53 (64%)
		EGF_Lam	290..339	CDD:238012	35/48 (73%)
		NTR_netrin-1_like	384..509	CDD:239634	43/187 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9271
eggNOG	1	0.900	-	-		E1_KOG3512
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.870