DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetA and unc-6

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_509165.1	Gene:	unc-6 / 180961	WormBaseID:	WBGene00006746	Length:	612	Species:	Caenorhabditis elegans

Alignment Length:	710	Identity:	302/710 - (42%)
Similarity:	401/710 - (56%)	Gaps:	138/710 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ISNDVYFKMFSQQAPPEDPCYNKAHEPRACIPDFVNAAYDAPVVASSTCGSSGAQRYCEYQDH-- 83
            |::..||..||.:||..|||::....|..|:|:|:|||:..||:||.|||::...:||..::.
Worm    18 IAHGAYFSQFSMRAPDHDPCHDHTGRPVRCVPEFINAAFGKPVIASDTCGTNRPDKYCTVKEGPD 82

  Fly    84 ---ERSCHTCDMTDPLRSFPARSLTDLNNSNNVTCWRSEPVTGSGDNVTLTLSLGKKFELTYVIL 145
               ...|.|||..:..:|.||..|||||:..|:|||.|.| :.|..||:||||||||||||||.:
Worm    83 GIIREQCDTCDARNHFQSHPASLLTDLNSIGNMTCWVSTP-SLSPQNVSLTLSLGKKFELTYVSM 146

  Fly   146 QLCPHAPRPDSMVIYKSTDHGLSWQPFQFFSSQCRRLFGRPARQSTGRHNEHEARC--SDVTRPL 208
            ..|...  ||||.:|||.|.|.:|.||||:||:|||:|||....|..:.||.||.|  |.:..|.
Worm   147 HFCSRL--PDSMALYKSADFGKTWTPFQFYSSECRRIFGRDPDVSITKSNEQEAVCTASHIMGPG 209

  Fly   209 VSRIAFSTLEGRPSSRDLDSSPVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLASGKYS 273
            .:|:||..||.|||:::.::|||||||||||||:|||.||. ||...|..|    :.|:.|
Worm   210 GNRVAFPFLENRPSAQNFENSPVLQDWVTATDIKVVFSRLS-PDQAELYGL----SNDVNS---- 265

  Fly   274 VPLANGPAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTDASGQLNCECSHNT 338
                   .||..:..:       .....|::.:.:||||||||||||:|..|..|:..|:|.|||
Worm   266 -------YGNETDDEV-------KQRYFYSMGELAVGGRCKCNGHASRCIFDKMGRYTCDCKHNT 316

  Fly   339 AGRDCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNCRHST 403
            ||.:||.|||||:||||.||||..||.|..||||:||::|||:.|:||||...|||||.||||:|
Worm   317 AGTECEMCKPFHYDRPWGRATANSANSCVACNCNQHAKRCRFDAELFRLSGNRSGGVCLNCRHNT 381

  Fly   404 TGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKDGVTGLTCNRCARG 468
            .|||||.||.||.||.:.|:||||.||:|.|||:||.||.||.:||||.||.||||.||||||:|
Worm   382 AGRNCHLCKPGFVRDTSLPMTHRKACKSCGCHPVGSLGKSCNQSSGQCVCKPGVTGTTCNRCAKG 446

  Fly   469 YQQSRSHIAPCIKQPPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGMAAQSQYYRTEGGREC 533
            ||||||.:.||||.|.:                        .|..|::....|.|         |
Worm   447 YQQSRSTVTPCIKIPTK------------------------ADFIGSSHSEEQDQ---------C 478

  Fly   534 GKCRVSTKRLNLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVADYEMDQVQPGSARSP 598
            .|||:..||||..||||||:|:...|         ||||:
Worm   479 SKCRIVPKRLNQKKFCKRDHAVQMVV---------VSREM------------------------- 509

  Fly   599 ITGVYEFQAADYPNPNPNPRGSEMERFDLQIQAVFKRSRPGESSGAGNVYGMPNTTLKRGPMT-W 662
            :.|                    ..::.:.:::||||             |..|  ::||..: |
Worm   510 VDG--------------------WAKYKIVVESVFKR-------------GTEN--MQRGETSLW 539

  Fly   663 IIPTKDLECRCPRIRVNRSYLILGR-DSEAPPGYLGIGPHSIVIEWKEDWYRRMKRFQRR 721
            |.| :.:.|:||::||.|.||:||: ||:.....|.:.|.::::||::|...::.||.::
Worm   540 ISP-QGVICKCPKLRVGRRYLLLGKNDSDHERDGLMVNPQTVLVEWEDDIMDKVLRFSKK 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	114/242 (47%)
		EGF_Lam	312..357	CDD:238012	30/44 (68%)
		EGF_Lam	369..426	CDD:238012	37/56 (66%)
		EGF_Lam	431..479	CDD:238012	33/47 (70%)
		NTR_netrin-1_like	545..723	CDD:239634	43/179 (24%)
unc-6	NP_509165.1	LamNT	41..289	CDD:214532	118/273 (43%)
		EGF_Lam	290..333	CDD:238012	28/42 (67%)
		Laminin_EGF	347..400	CDD:278482	35/52 (67%)
		Laminin_EGF	410..453	CDD:278482	32/42 (76%)
		NTR_netrin-1_like	490..604	CDD:239634	43/179 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159483
Domainoid	1	1.000	212	1.000	Domainoid score	I1617
eggNOG	1	0.900	-	-		E1_KOG3512
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	559	1.000	Inparanoid score	I595
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48023
OrthoDB	1	1.010	-	-		D368755at33208
OrthoFinder	1	1.000	-	-		FOG0003523
OrthoInspector	1	1.000	-	-		oto20142
orthoMCL	1	0.900	-	-		OOG6_104609
Panther	1	1.100	-	-	LDO	PTHR10574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1381
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810