Protein Alignment NetA and unc-6

DIOPT Version :10

• Sequence 1: NP_511154.3
• Gene: NetA / 32398
• FlyBaseID: FBgn0015773
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_509165.1
• Gene: unc-6 / 180961
• WormBaseID: WBGene00006746
• Length: 612
• Species: Caenorhabditis elegans
• Alignment Length: 710
• Identity: 302/710 - (42%)
• Similarity: 401/710 - (56%)
• Gaps: 138/710 - (19%)

  Fly    21 ISNDVYFKMFSQQAPPEDPCYNKAHEPRACIPDFVNAAYDAPVVASSTCGSSGAQRYCEYQDH-- 83
            |::..||..||.:||..|||::....|..|:|:|:|||:..||:||.|||::...:||..::.
 Worm    18 IAHGAYFSQFSMRAPDHDPCHDHTGRPVRCVPEFINAAFGKPVIASDTCGTNRPDKYCTVKEGPD 82

  Fly    84 ---ERSCHTCDMTDPLRSFPARSLTDLNNSNNVTCWRSEPVTGSGDNVTLTLSLGKKFELTYVIL 145
               ...|.|||..:..:|.||..|||||:..|:|||.|.| :.|..||:||||||||||||||.:
 Worm    83 GIIREQCDTCDARNHFQSHPASLLTDLNSIGNMTCWVSTP-SLSPQNVSLTLSLGKKFELTYVSM 146

  Fly   146 QLCPHAPRPDSMVIYKSTDHGLSWQPFQFFSSQCRRLFGRPARQSTGRHNEHEARC--SDVTRPL 208
            ..|...  ||||.:|||.|.|.:|.||||:||:|||:|||....|..:.||.||.|  |.:..|.
 Worm   147 HFCSRL--PDSMALYKSADFGKTWTPFQFYSSECRRIFGRDPDVSITKSNEQEAVCTASHIMGPG 209

  Fly   209 VSRIAFSTLEGRPSSRDLDSSPVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLASGKYS 273
            .:|:||..||.|||:::.::|||||||||||||:|||.||. ||...|..|    :.|:.|
 Worm   210 GNRVAFPFLENRPSAQNFENSPVLQDWVTATDIKVVFSRLS-PDQAELYGL----SNDVNS---- 265

  Fly   274 VPLANGPAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTDASGQLNCECSHNT 338
                   .||..:..:       .....|::.:.:||||||||||||:|..|..|:..|:|.|||
 Worm   266 -------YGNETDDEV-------KQRYFYSMGELAVGGRCKCNGHASRCIFDKMGRYTCDCKHNT 316

  Fly   339 AGRDCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNCRHST 403
            ||.:||.|||||:||||.||||..||.|..||||:||::|||:.|:||||...|||||.||||:|
 Worm   317 AGTECEMCKPFHYDRPWGRATANSANSCVACNCNQHAKRCRFDAELFRLSGNRSGGVCLNCRHNT 381

  Fly   404 TGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKDGVTGLTCNRCARG 468
            .|||||.||.||.||.:.|:||||.||:|.|||:||.||.||.:||||.||.||||.||||||:|
 Worm   382 AGRNCHLCKPGFVRDTSLPMTHRKACKSCGCHPVGSLGKSCNQSSGQCVCKPGVTGTTCNRCAKG 446

  Fly   469 YQQSRSHIAPCIKQPPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGMAAQSQYYRTEGGREC 533
            ||||||.:.||||.|.:                        .|..|::....|.|         |
 Worm   447 YQQSRSTVTPCIKIPTK------------------------ADFIGSSHSEEQDQ---------C 478

  Fly   534 GKCRVSTKRLNLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVADYEMDQVQPGSARSP 598
            .|||:..||||..||||||:|:...|         ||||:
 Worm   479 SKCRIVPKRLNQKKFCKRDHAVQMVV---------VSREM------------------------- 509

  Fly   599 ITGVYEFQAADYPNPNPNPRGSEMERFDLQIQAVFKRSRPGESSGAGNVYGMPNTTLKRGPMT-W 662
            :.|                    ..::.:.:::||||             |..|  ::||..: |
 Worm   510 VDG--------------------WAKYKIVVESVFKR-------------GTEN--MQRGETSLW 539

  Fly   663 IIPTKDLECRCPRIRVNRSYLILGR-DSEAPPGYLGIGPHSIVIEWKEDWYRRMKRFQRR 721
            |.| :.:.|:||::||.|.||:||: ||:.....|.:.|.::::||::|...::.||.::
 Worm   540 ISP-QGVICKCPKLRVGRRYLLLGKNDSDHERDGLMVNPQTVLVEWEDDIMDKVLRFSKK 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_511154.3	LamNT	44..280	CDD:214532	114/242 (47%)
		EGF_Lam	312..357	CDD:238012	30/44 (68%)
		EGF_Lam	369..426	CDD:238012	37/56 (66%)
		EGF_Lam	431..479	CDD:238012	33/47 (70%)
		NTR_netrin-1_like	545..723	CDD:239634	43/179 (24%)
unc-6	NP_509165.1	LamNT	41..289	CDD:214532	118/273 (43%)
		EGF_Lam	290..333	CDD:238012	28/42 (67%)
		Laminin_EGF	347..400	CDD:395007	35/52 (67%)
		Laminin_EGF	410..453	CDD:395007	32/42 (76%)
		NTR_netrin-1_like	490..604	CDD:239634	43/179 (24%)