DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetA and epi-1

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001294008.1	Gene:	epi-1 / 177956	WormBaseID:	WBGene00001328	Length:	3715	Species:	Caenorhabditis elegans

Alignment Length:	775	Identity:	194/775 - (25%)
Similarity:	280/775 - (36%)	Gaps:	220/775 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PDFVNAAYDAPVVASSTCGSSGAQR----YC--------------EYQDHER------------- 85
            |..:..::..|:.|:||||....|.    ||              .|||.|:
Worm    32 PSQITISHRKPITATSTCGEIQGQPVTEIYCSLTGSTQYTPLNSYSYQDDEQQKSWSQYENPMVR 96

  Fly    86 ---SCHTCDMTDPLRSFPARSLTDLNNSNNVTCWRSEPVT-GSGDN-VTLTLSLGKKFELTYVIL 145
               .|..|:..:. .|.||.::.|.|||    .|.|.|:: |...| |.:|:.|.::|.:.||.:
Worm    97 GGHGCGHCNAGNE-NSHPAANMVDGNNS----WWMSPPLSRGLQHNEVNITIDLEQEFHVAYVWI 156

  Fly   146 QLCPHAPRPDSMVIYKSTDHGLSWQPFQFF---SSQCRRLFGRPARQSTGRHNEHEARCSDVT-- 205
            |:. ::|||.|.|:.:|||||.::||:..|   :::|.|.||..:.......:....| :|:.
Worm   157 QMA-NSPRPGSWVLERSTDHGKTYQPWFNFAENAAECMRRFGMESLSPISEDDSVTCR-TDMASL 219

  Fly   206 RPLV-SRIAFSTLEGRPSSRDLDSSPVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLAS 269
            :||. :.:....||.|||||...:|..||::..||::|                |...|...|
Worm   220 QPLENAEMVIRILEHRPSSRQFATSEALQNFTRATNVR----------------LRLLGTRTL-- 266

  Fly   270 GKYSVPLANGPAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKC---STDASGQLN 331
                       .|:.::.|...| .|......|||.:..:||||.|||||..|   .......|.
Worm   267 -----------QGHLMDMNEWRD-PTVTRRYFYAIKEIMIGGRCVCNGHAVTCDILEPQRPKSLL 319

  Fly   332 CECSHNTAGRDCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQGV----- 391
            |.|.|||.|..||||.|....:.|..|||.....|:.|||...:.:|.::.|:....|.:
Worm   320 CRCEHNTCGDMCERCCPGFVQKQWQAATAHNNFTCEACNCFGRSNECEYDAEVDLNKQSIDSQGN 384

  Fly   392 --SGGVCQNCRHSTTGRNCHQCKEGFYRDATKPLTHRKVCKACDCHP------------------ 436
              .||||:|||.:|.|.||::|..|::|.........:.||.|||.|
Worm   385 YEGGGVCKNCRENTEGVNCNKCSFGYFRPEGVTWNEPQPCKVCDCDPDKHTGACAEETGKCECLP 449

  Fly   437 ---------------------------IGSSGKICNSTSGQCPCKDGVTGLTCNRCARGYQQSRS 474
                                       .|:.|.:|....||||||.|..|..|..||.||....:
Worm   450 RFVGEDCDQCASGYYDAPKCKPCECNVNGTIGDVCLPEDGQCPCKAGFGGTFCETCADGYTNVTA 514

  Fly   475 HIAPCIKQPPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGMAAQSQYYRTEGGRECGKCRVS 539
            ....|:                        ...:|.:....:....|.:......|..|.||:|.
Worm   515 GCVECV------------------------CDATGSEHGNCSASTGQCECKPAYAGLSCDKCQVG 555

  Fly   540 TKRLNLNKFCKRD-----YAIMAKVIGRDTSSEAVSREVQRRAMDPDVADY-------------- 585
            ....:. |||..|     ..:..:..|:....|..:.:...|.   |:|.|
Worm   556 YFGDDC-KFCNCDPMGTEGGVCDQTTGQCLCKEGFAGDKCDRC---DIAFYGYPNCKACACDGAG 616

  Fly   586 ----EMDQVQPGSARSPITGVYEFQ-----AADYPNPNPNPRGSEM-------ERFDLQIQAVFK 634
                |.|..   |.:.|..|.:..:     ||.:.| .|:.||.|.       :..|...|...|
Worm   617 ITSPECDAT---SGQCPCNGNFTGRTCDKCAAGFYN-YPDCRGCECLLSGAKGQTCDSNGQCYCK 677

  Fly   635 RSRPGESSG--AGNVYGMPNTTLKRGPMTWIIPTKDLECRCPRIRVNRSYLILGRDSEAP 692
            .:..||...  ..|.|..|...               ||.|....|.|.:  .|.|..:|
Worm   678 GNFEGERCDRCKPNFYNFPICE---------------ECNCNPSGVTRDF--QGCDKVSP 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	72/269 (27%)
		EGF_Lam	312..357	CDD:238012	21/47 (45%)
		EGF_Lam	369..426	CDD:238012	20/63 (32%)
		EGF_Lam	431..479	CDD:238012	20/92 (22%)
		NTR_netrin-1_like	545..723	CDD:239634	38/185 (21%)
epi-1	NP_001294008.1	LamNT	24..296	CDD:214532	79/300 (26%)
		EGF_Lam	297..345	CDD:238012	21/47 (45%)
		Laminin_EGF	427..474	CDD:278482	4/46 (9%)
		EGF_Lam	471..520	CDD:238012	16/48 (33%)
		EGF_Lam	519..564	CDD:214543	9/69 (13%)
		Laminin_EGF	564..612	CDD:278482	8/50 (16%)
		Laminin_EGF	610..658	CDD:278482	11/51 (22%)
		Laminin_EGF	656..703	CDD:278482	11/61 (18%)
		Laminin_EGF	701..753	CDD:278482	7/22 (32%)
		Laminin_EGF	756..806	CDD:278482
		EGF_Lam	808..854	CDD:238012
		CBM6-CBM35-CBM36_like	855..988	CDD:271143
		EGF_Lam	1425..1468	CDD:238012
		EGF_Lam	1472..1515	CDD:238012
		Laminin_EGF	1517..1567	CDD:278482
		Laminin_EGF	1565..1613	CDD:278482
		LamB	1669..1793	CDD:214597
		EGF_Lam	1840..1883	CDD:238012
		Laminin_EGF	1891..1945	CDD:278482
		EGF_Lam	1947..1998	CDD:238012
		EGF_Lam	2001..2045	CDD:214543
		EGF_Lam	2048..2092	CDD:214543
		EGF_Lam	2095..2140	CDD:214543
		Tar	<2145..2378	CDD:223910
		BAR	2289..2486	CDD:299863
		Apolipoprotein	2289..2472	CDD:279749
		COG1340	2414..2690	CDD:224259
		ApoLp-III_like	2510..2635	CDD:304399
		Laminin_II	2589..2730	CDD:283628
		LamG	2704..2875	CDD:238058
		LamG	2909..3057	CDD:238058
		LamG	3353..3510	CDD:238058
		LamG	3532..3682	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910