DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetA and lam-3

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_492775.2	Gene:	lam-3 / 172952	WormBaseID:	WBGene00002248	Length:	3102	Species:	Caenorhabditis elegans

Alignment Length:	729	Identity:	191/729 - (26%)
Similarity:	288/729 - (39%)	Gaps:	181/729 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 EDPCYNK---AHEPRACIPDFVNAAYDAPVVASSTCGSSGAQRYCEYQDH----------ERSCH 88
            ||..|::   :...|...|:..|.|.::.:.|:.|||...|:.||:..:|          ...|.
Worm    32 EDSNYHEFISSESERGLFPNIFNLATNSLITATDTCGQYTAEEYCKLVEHVLLRKTTNTQSPQCD 96

  Fly    89 TCDMTDPLRSFPARSLTDLNNSNNVTCWRSEPVTGSG---DNVTLTLSLGKKFELTYVILQLCPH 150
            .||..:..:..|.....|     ....|...|...:|   :.|.:|:.|.:::::.|:||:: .:
Worm    97 ICDANNVHKRHPIEYAID-----GTRRWWQSPSLANGLRFEKVNITIDLRQEYQVAYIILKM-GN 155

  Fly   151 APRPDSMVIYKSTDHGLSWQPFQFFSSQ---CRRLFGRPARQSTGR-HNEHEARC----SDVTRP 207
            :|||.:.|:.||.| |..::|:|:::.|   |.|.||.||.....| ..|.|..|    |.:| |
Worm   156 SPRPGTWVLEKSLD-GEYYEPWQYYAMQDAECMRQFGIPATTGVPRFQKEDEVHCTSEYSKIT-P 218

  Fly   208 LVS-RIAFSTLEGRPSSRDLDSSPVLQDWVTATDIRVVFHRLQRPDPQAL------LSLEAGGAT 265
            |.: .|..|.:.|||.:.  ::|..||.:.     |..|.||:...|:.|      ::.::....
Worm   219 LENGEIHTSLVNGRPGAE--NTSLELQKFT-----RARFVRLRLISPRTLNADLMIINKKSDSLD 276

  Fly   266 DLASGKYSVPLANGPAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTD-ASGQ 329
            ...:.:|                            .|:|||.|:||:|.|.|||..|.:| .:||
Worm   277 KSVTMRY----------------------------FYSISDISIGGQCICYGHAESCPSDPVTGQ 313

  Fly   330 LNCECSHNTAGRDCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFR-----LSQ 389
            ..|||.|||.|..|.||.|.....||...|....|.|::|.|..||..|.::.|:.|     ..:
Worm   314 FKCECRHNTCGESCNRCCPLFNQLPWKPGTNSHPNVCQQCQCFNHAHSCVYDDELDRNKWSITPE 378

  Fly   390 GV--SGGVCQNCRHSTTGRNCHQCKEGFYRDATKPLTHRK--VCKACDCHPIGSSGKIC------ 444
            ||  .||.|..|.|:|.|.||.:||:|:||.:  .|:|.:  .|:.|:|.|:||....|
Worm   379 GVYEGGGRCLECAHNTEGFNCERCKDGYYRPS--GLSHYREDACRTCECDPVGSVSDACVRDDQS 441

  Fly   445 ---NSTSGQCPCKDGVTGLTCNRCARGYQQSRSH--IAPCIKQPPRMINMLDTQNTAPEPDEPES 504
               ....|.|.||.|..|..|.|||.||   |:|  ..||.......:| .||.:
Worm   442 AENGQKPGDCICKPGFGGRRCERCAPGY---RNHPTCEPCPCNRAGSVN-FDTCD---------- 492

  Fly   505 SPGSGGDRNGAAGMAAQSQYYRTEGGRECGKCRVSTKRLNLNK-------FC----------KRD 552
                          .|..|......|..|.:|:..|..|:.:.       ||          |.:
Worm   493 --------------GASCQCKANVEGIYCDRCKAGTIHLSASNPLGCQPCFCFGHSSTCTQGKWN 543

  Fly   553 YAIMAKVIGRDTSSEAVSREVQRRAMDPDVADYEMDQVQPGSARSPITGVYEFQAADYPNPN--- 614
            .|.:...||...:.....::|:....:.:|..:..:|.|..|       :|.::|.|....|
Worm   544 KAQIINNIGWHLTDLTGGKDVKPEVENGEVLMFNANQNQDRS-------LYYWKAPDSFKGNMLN 601

  Fly   615 -------------PNPRGSEMERFDLQIQAVFKRSRPGESSGAGNVYGMPNTTLKRGPMTWIIPT 666
                         |..:|:.:...|:.|          |.:|....|......|.|..||..||.
Worm   602 SYGGYLHYDVYYVPTEQGATVFVADVAI----------EGNGIKIEYHSRIEFLPREKMTVAIPM 656

  Fly   667 KDL------ECRCP 674
            .:|      |.|.|
Worm   657 SELSGWYNAEARSP 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	66/263 (25%)
		EGF_Lam	312..357	CDD:238012	22/45 (49%)
		EGF_Lam	369..426	CDD:238012	24/63 (38%)
		EGF_Lam	431..479	CDD:238012	20/58 (34%)
		NTR_netrin-1_like	545..723	CDD:239634	32/169 (19%)
lam-3	NP_492775.2	LamNT	42..294	CDD:214532	71/294 (24%)
		EGF_Lam	296..343	CDD:238012	22/46 (48%)
		EGF_Lam	<384..411	CDD:214543	14/28 (50%)
		Laminin_EGF	423..480	CDD:278482	22/59 (37%)
		EGF_Lam	477..526	CDD:238012	12/73 (16%)
		LamB	583..711	CDD:214597	22/105 (21%)
		EGF_Lam	774..818	CDD:238012
		Laminin_EGF	889..943	CDD:278482
		EGF_Lam	941..985	CDD:214543
		EGF_Lam	988..1033	CDD:214543
		EGF_Lam	1036..1083	CDD:214543
		Laminin_EGF	1086..1134	CDD:278482
		EGF_Lam	1133..1179	CDD:238012
		Laminin_EGF	1181..1229	CDD:278482
		Laminin_EGF	1227..1281	CDD:278482
		LamB	1341..1478	CDD:214597
		EGF_Lam	1539..1583	CDD:238012
		EGF_Lam	1590..1637	CDD:214543
		EGF_Lam	1646..1694	CDD:238012
		BAR	1848..2058	CDD:299863
		PspA	1864..2121	CDD:224755
		Laminin_II	2157..2286	CDD:283628
		LamG	2285..2443	CDD:214598
		LamG	2471..2622	CDD:238058
		LamG	2655..2821	CDD:238058
		LamG	2919..3065	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910