Protein Alignment NetA and Ntng2

DIOPT Version :9

• Sequence 1: NP_001285243.1
• Gene: NetA / 32398
• FlyBaseID: FBgn0015773
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_598008.1
• Gene: Ntng2 / 171171
• MGIID: 2159341
• Length: 589
• Species: Mus musculus
• Alignment Length: 521
• Identity: 138/521 - (26%)
• Similarity: 203/521 - (38%)
• Gaps: 161/521 - (30%)

  Fly    49 ACIP------DFVNAAYDAPVVASSTCGSSGAQRYCEYQDHERSCHTCDMTDPLRSFPARSLTDL 107
            ||.|      |:|....:.   :..|||.. .:|:|.:::.....:.||.::|..:.|.|.:.|.
Mouse    38 ACQPKVMRLKDYVKVKVEP---SGITCGDP-PERFCSHENPYLCSNECDASNPDLAHPPRLMFDR 98

  Fly   108 NNSNNVTCWRSEPVTGSGD----NVTLTLSLGKKFELTYVILQLCPHAPRPDSMVIYKSTDHGLS 168
            .:....|.|:|  ||.|..    ...:|||..|..|||..::....:. ||..||:.||.|:|.:
Mouse    99 EDEGLATYWQS--VTWSRYPSPLEANITLSWNKSVELTDDVVVTFEYG-RPTVMVLEKSLDNGRT 160

  Fly   169 WQPFQFFSSQCRRLFGRPARQS--TGRHNEHEARCSDVTRPLVSRIAFSTLE------------- 218
            |||:||::..|...||..||::  ....:.|...|::.    .||.|.|..|
Mouse   161 WQPYQFYAEDCMEAFGMSARRARDMSPSSAHRVLCTEE----YSRWAGSKKEKHVRFEVRDRFAI 221

  Fly   219 -GRPSSRDLD-------SSPVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLASGKYSVP 275
             ..|..|::|       |:..|:::.|.||:|:   ||.||   ||     ||........|.
Mouse   222 FAGPDLRNMDNLYTRMESAKGLKEFFTFTDLRM---RLLRP---AL-----GGTYVQRENLYK-- 273

  Fly   276 LANGPAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTDASGQLNCECSHNTAG 340
                                    ..||||:..|.||||||.||:.| |...|.|.|||.|||.|
Mouse   274 ------------------------YFYAISNIEVIGRCKCNLHANLC-TVREGSLQCECEHNTTG 313

  Fly   341 RDCERCKPFHFDRPWARAT---------------------------------------------- 359
            .||.|||.....|.|...:
Mouse   314 PDCGRCKKNFRTRAWRAGSYLPLPHGSPNACAAAGSAFGSQTKPPTMAPLGDSSFWPQVSSSAEA 378

  Fly   360 ----------AKEA---------------NECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNC 399
                      ||::               .|.::|.|..|:.:|.: ::...:.      .|.:|
Mouse   379 VAISVAVPSQAKDSTLFELKPRSPQVIPIEEFQDCECYGHSNRCSY-IDFLNVV------TCVSC 436

  Fly   400 RHSTTGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKDGVTGLTCNR 464
            :|:|.|::|..|:.|:||:.:..|....||..|:|:.|||....||.| |.|.|::|..|..|:.
Mouse   437 KHNTRGQHCQHCRLGYYRNGSAELDDENVCIECNCNQIGSVHDRCNET-GFCECREGAVGPKCDD 500

  Fly   465 C 465
            |
Mouse   501 C 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	72/263 (27%)
		EGF_Lam	312..357	CDD:238012	25/44 (57%)
		EGF_Lam	369..426	CDD:238012	15/56 (27%)
		EGF_Lam	431..479	CDD:238012	15/35 (43%)
		NTR_netrin-1_like	545..723	CDD:239634
Ntng2	NP_598008.1	Laminin_N	60..285	CDD:278484	72/269 (27%)
		NGL discriminant loop I. /evidence=ECO:0000250	69..88		4/18 (22%)
		NGL discriminant loop II. /evidence=ECO:0000250	201..203		1/1 (100%)
		NGL discriminant loop III. /evidence=ECO:0000250	264..267		0/2 (0%)
		EGF_Lam	286..332	CDD:238012	25/46 (54%)
		EGF_Lam	413..461	CDD:238012	14/54 (26%)
		Laminin_EGF	469..516	CDD:278482	15/34 (44%)
		EGF_2	516..546	CDD:285248

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3512
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810