Protein Alignment NetA and Lamb3

DIOPT Version :10

• Sequence 1: NP_511154.3
• Gene: NetA / 32398
• FlyBaseID: FBgn0015773
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_032510.2
• Gene: Lamb3 / 16780
• MGIID: 99915
• Length: 1168
• Species: Mus musculus
• Alignment Length: 706
• Identity: 179/706 - (25%)
• Similarity: 267/706 - (37%)
• Gaps: 210/706 - (29%)

  Fly    40 CYNKAHEPRACIPDFVNAAYDAPV-----------VASSTCGSSGAQRYC-EYQDHERSCHTCDM 92
            |..:|....||.|         ||           .||||||.:..:.|| :|...:..|..||.
Mouse    16 CAQQACSRGACYP---------PVGDLLIGRTQLLRASSTCGLTKPETYCTQYGQWQMKCCKCDS 71

  Fly    93 TDPLRSFPARSLTDL-NNSNNVTCWRSEPVTGSGDNVTLTLSLGKKFELTYVILQLCPHAPRPDS 156
            ..| |::.:..:.:: ::|..:..|:|:   .....|:|.|.|.|:.:|..:::..  ....|..
Mouse    72 RLP-RNYNSHRVENVASSSGPMRWWQSQ---NDVSPVSLQLDLDKRMQLQDIMMDF--KGLTPAG 130

  Fly   157 MVIYKSTDHGLSWQPFQFFSSQCRRLF-----GRPARQSTGRHNEHEARCSDVTRPLVSRIAFST 216
            |:|.:|:|.|.:|:.:|:.::.|...|     |:|       .|..:.||    |||..|.....
Mouse   131 MLIERSSDFGKTWRVYQYLATDCASTFPQVHQGQP-------KNWQDVRC----RPLSQRPNGHL 184

  Fly   217 LEGRPSSRDLD--------SSPVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLASGKYS 273
            ..|:.....:|        .|..:|:....|::||.|.:| .|.||              .|.|.
Mouse   185 TGGKVQLNLMDLASAIPASQSKKIQELGDITNLRVNFTKL-APVPQ--------------RGSYP 234

  Fly   274 VPLANGPAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTDASG-----QLN-- 331
             |.|                       ::|:|...:.|.|.|:|||.:|:.:..|     |:|
Mouse   235 -PSA-----------------------YFAVSQLRLQGSCFCHGHADRCAPNPGGSTTAVQVNNV 275

  Fly   332 CECSHNTAGRDCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQGVSGGVC 396
            |.|.|||||.:|:||.||:.:|||..|..::.:||:.|:||.|:..|.|:..:|..|||.:||||
Mouse   276 CVCQHNTAGPNCDRCAPFYNNRPWRPAEGQDTHECQRCDCNGHSETCHFDPAVFAASQGTNGGVC 340

  Fly   397 QNCRHSTTGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGS-SGKICNSTSGQCPCKD----- 455
            .|||..|.|:||.:|:..::|:........:.|..|:|.|.|: .|..|:..:|||.||:
Mouse   341 DNCRDHTEGKNCERCQLHYFRNRRPSAPIHETCIPCECDPDGAVQGAPCDRLTGQCVCKEYVQGE 405

  Fly   456 -------GVTGLT----------------------------------------CNRCARGYQQSR 473
                   |.||||                                        |::||..:.:..
Mouse   406 RCDLCKPGFTGLTFANPKGCHACDCSILGARKDMPCEEETGRCLCLPNVVGPKCDQCAPSHWKLA 470

  Fly   474 SHIA--PCIKQPPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGMAAQSQYYR-----TEGGR 531
            |.:.  ||...|...::....|.|...|           .|.|..|:...|...|     |.|..
Mouse   471 SGLGCEPCACDPRNSLSSQCNQFTGQCP-----------CREGFGGLTCSSAAIRQCPDQTYGHV 524

  Fly   532 ECGKCRVSTKRLNLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVADYEMDQVQPGSA- 595
            ..| ||.          |..|:        |.|......:...|....|.......||.|.|..
Mouse   525 ATG-CRA----------CDCDF--------RGTEGPGCDKASGRCLCRPGFTGPRCDQCQRGHCD 570

  Fly   596 RSPITGVYE--FQAADYPNPNPNPRGSEMERFDLQIQA----VFKRSRPGESSGAG 645
            |.|:.....  |||.|               .|||.||    ..:.:..|..:|.|
Mouse   571 RYPVCVACHSCFQAYD---------------TDLQEQARRLHSLRNATEGLWTGTG 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_511154.3	LamNT	44..280	CDD:214532	64/261 (25%)
		EGF_Lam	312..357	CDD:238012	24/51 (47%)
		EGF_Lam	369..426	CDD:238012	23/56 (41%)
		EGF_Lam	431..479	CDD:238012	20/102 (20%)
		NTR_netrin-1_like	545..723	CDD:239634	24/108 (22%)
Lamb3	NP_032510.2	Laminin_N	20..248	CDD:470680	66/292 (23%)
		EGF_Lam	249..301	CDD:238012	24/51 (47%)
		Laminin_EGF	313..367	CDD:395007	23/53 (43%)
		Laminin_EGF	376..425	CDD:395007	16/48 (33%)
		Laminin_EGF	428..475	CDD:395007	4/46 (9%)
		Laminin_EGF	478..531	CDD:395007	15/74 (20%)
		EGF_Lam	530..579	CDD:238012	12/66 (18%)
		Domain II	576..781		12/51 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	723..760
		Domain alpha	782..812
		Domain I	813..1168
		SMC_prok_B	<830..1161	CDD:274008
		cc_LAMB_C	1098..1168	CDD:424069