Protein Alignment NetA and Lama2

DIOPT Version :10

• Sequence 1: NP_511154.3
• Gene: NetA / 32398
• FlyBaseID: FBgn0015773
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_032507.2
• Gene: Lama2 / 16773
• MGIID: 99912
• Length: 3118
• Species: Mus musculus
• Alignment Length: 807
• Identity: 207/807 - (25%)
• Similarity: 322/807 - (39%)
• Gaps: 201/807 - (24%)

  Fly     5 ILLLLLGTTRFSPIQCISNDVYFKMFSQQAPPEDPCYNKAHEPRACIPDFVNAAYDAPVVASSTC 69
            :|||||||...|..|           .:|        ::||:.|...|..:|.|.:|.:..::||
Mouse     9 LLLLLLGTLEGSQTQ-----------RRQ--------SQAHQQRGLFPAVLNLASNALITTNATC 54

  Fly    70 GSSGAQRYCEYQDH-------ERSCHTCDM--TDPLRSFPARSLTDLNNSNNVTCWRSEPVTGSG 125
            |..|.:.||:..:|       ...|..|:.  ::|.:..|..:..|..|    |.|:|..:....
Mouse    55 GEKGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPYQRHPITNAIDGKN----TWWQSPSIKNGV 115

  Fly   126 D--NVTLTLSLGKKFELTYVILQLCPHAPRPDSMVIYKSTDHGLSWQPFQFFS---SQCRRLFG- 184
            :  .||:||.|.:.|::.|||:: ..::|||.:.::.:|.| .:.::|:|:.:   ::|..|:.
Mouse   116 EYHYVTITLDLQQVFQIAYVIVK-AANSPRPGNWILERSLD-DVEYKPWQYHAVTDTECLTLYNI 178

  Fly   185 RPARQSTGRHNEHEARCSDV---TRPLVS-RIAFSTLEGRPSSRDLDSSPVLQDWVTATDIRVVF 245
            .|.........:.|..|:..   ..||.: .|..|.:.||||:.  |.||.|.::.:|..||:.|
Mouse   179 YPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSAD--DPSPELLEFTSARYIRLRF 241

  Fly   246 HRLQRPDPQALLSLEAGGATDLASGKYSVPLANGPAGNNIEANLGGDVATSGSGLHYAISDFSVG 310
            .|::        :|.|    ||....:..|....|            :.|  ...:|::.|.|||
Mouse   242 QRIR--------TLNA----DLMMFAHKDPREIDP------------IVT--RRYYYSVKDISVG 280

  Fly   311 GRCKCNGHASKCSTD-ASGQLNCECSHNTAGRDCERCKPFHFDRPWARATAKEANECKECNCNKH 374
            |.|.|.|||..|..| |:.:..|||.|||.|..|:||.|....:||...|....:||:.|||:..
Mouse   281 GMCICYGHARACPLDPATNKSRCECEHNTCGESCDRCCPGFHQKPWRAGTFLTKSECEACNCHGK 345

  Fly   375 ARQCRF-------NMEIFRLSQGVSGGVCQNCRHSTTGRNCHQCKEGFYRDATKPLTHRKVCKAC 432
            |.:|.:       |:.:....:.:.||||.||.|:|.|.||..|.:||:|.......:.:.|:.|
Mouse   346 AEECYYDETVASRNLSLNIHGKYIGGGVCINCTHNTAGINCETCVDGFFRPKGVSPNYPRPCQPC 410

  Fly   433 DCHPIGSSGKIC---------NSTSGQCPCKDGVTGLTCNRCARGYQQSRSHIAP-CIKQPPRMI 487
            .|.|.||..::|         ....|.|.||.|..|:.|:||.|||     |..| |  ||....
Mouse   411 HCDPTGSLSEVCVKDEKYAQRGLKPGSCHCKTGFGGVNCDRCVRGY-----HGYPDC--QPCNCS 468

  Fly   488 NMLDTQNTAPEPDEPESSPGS------GGD----RNGAAGMAAQSQYYRTEGGRECGKCRVSTKR 542
            .:..|.      ::|...|.|      |.|    ::|...:...:|    :|..||....||.:
Mouse   469 GLGSTN------EDPCVGPCSCKENVEGEDCSRCKSGFFNLQEDNQ----KGCEECFCSGVSNR- 522

  Fly   543 LNLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVADYEMDQ---VQPGSARSPITGVYE 604
                  |:..|.....:  :|.....::....|..|.|.:.:.:..|   :....||..:...|.
Mouse   523 ------CQSSYWTYGNI--QDMRGWYLTDLSGRIRMAPQLDNPDSPQQISISNSEARKSLLDGYY 579

  Fly   605 FQAADYPNPN-----PNPRGS---------EMERFD----LQIQAVFKRSRPGESSGAGNVYGMP 651
            :.|   |.|.     |...|.         |.|..|    ||:..:|:.:....|:....||..|
Mouse   580 WSA---PPPYLGNRLPAVGGQLSFTISYDLEEEEDDTEKILQLMIIFEGNDLRISTAYKEVYLEP 641

  Fly   652 N------TTLKRGPMT------------WIIPTKDLECRCPRIRVNRSYLILGRDS--------- 689
            :      .:||....|            ::|...:||....:|..|     ||.|:
Mouse   642 SEEHIEEVSLKEEAFTIHGTNLPVTRKDFMIVLTNLERVLMQITYN-----LGMDAIFRLSSVNL 701

  Fly   690 -------------------EAPPGYLG 697
                               :.||||.|
Mouse   702 ESAVPYPTDRRIATDVEVCQCPPGYSG 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_511154.3	LamNT	44..280	CDD:214532	66/254 (26%)
		EGF_Lam	312..357	CDD:238012	21/45 (47%)
		EGF_Lam	369..426	CDD:238012	21/63 (33%)
		EGF_Lam	431..479	CDD:238012	20/57 (35%)
		NTR_netrin-1_like	545..723	CDD:239634	41/220 (19%)
Lama2	NP_032507.2	LamNT	29..281	CDD:214532	72/285 (25%)
		EGF_Lam	283..330	CDD:238012	21/46 (46%)
		Laminin_EGF	410..467	CDD:395007	23/63 (37%)
		Laminin_EGF	465..511	CDD:395007	8/55 (15%)
		Laminin_B	579..718	CDD:459652	26/146 (18%)
		EGF_Lam	752..801	CDD:238012
		EGF_Lam	802..859	CDD:238012
		EGF_Lam	860..912	CDD:238012
		EGF_Lam	913..960	CDD:238012
		EGF_Lam	963..1007	CDD:214543
		EGF_Lam	1009..1054	CDD:238012
		Laminin_EGF	1056..1104	CDD:395007
		Laminin_EGF	1102..1159	CDD:395007
		LamB	1225..1360	CDD:214597
		EGF_Lam	<1375..1403	CDD:238012
		Laminin_EGF	1416..1462	CDD:395007
		Laminin_EGF	1465..1520	CDD:395007
		EGF_Lam	1523..1566	CDD:214543
		Domain II and I	1570..2140
		Laminin_I	1589..1848	CDD:310534
		COG4372	1694..2054	CDD:443500
		Laminin_II	2033..2168	CDD:368703
		Laminin_G_1	2170..2310	CDD:395008
		Laminin_G_1	2364..2503	CDD:395008
		LamG	2524..2686	CDD:238058
		Laminin_G_1	2789..2917	CDD:395008
		LamG	2937..3089	CDD:238058