DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetA and NTN5

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_665806.1	Gene:	NTN5 / 126147	HGNCID:	25208	Length:	489	Species:	Homo sapiens

Alignment Length:	722	Identity:	208/722 - (28%)
Similarity:	285/722 - (39%)	Gaps:	261/722 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLLLGTTRFSPIQCISNDVYFKMFSQQAPPEDPCYNKAHEPRACIPDFVNAAYDAPVVASSTCG 70
            ||||||                     || ..||||:....|:.|:|.....|    .||:
Human     7 LLLLLG---------------------QA-TADPCYDPQGRPQFCLPPVTQLA----AVAA---- 41

  Fly    71 SSGAQRYCEYQDHERSCHTCDMTDPLRSFPARSLTDLNNSNNVTCWRSEPVTGSGDNVTLTLSLG 135
                           ||.......|.....||.          ||           |.:|||:||
Human    42 ---------------SCPQACALSPGNHLGARE----------TC-----------NGSLTLALG 70

  Fly   136 KKFELTYVILQLCPHAPRPDSMVIYKSTDHGLSWQPFQFFSSQCRRLFGRPARQSTGRHNEHEAR 200
            ..|.||.|.|:.|  .|.|.::::..:...|..|          |.|:.||
Human    71 GPFLLTSVSLRFC--TPGPPALILSAAWASGGPW----------RLLWHRP-------------- 109

  Fly   201 CSDVTRPLVSRIAFSTLEGRPSSRDLDSSPVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGAT 265
                        |:....|.|.                   ||.||  ..|.|:|.:
Human   110 ------------AWPGALGGPE-------------------RVTFH--STPGPKATV-------- 133

  Fly   266 DLASGKYSVPLANGPAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTDASGQL 330
                           |.:::....||....:.:||.         |||:|:|||::|:..|...
Human   134 ---------------AASHLRVEFGGQAGLAAAGLR---------GRCQCHGHAARCAARARPP- 173

  Fly   331 NCECSHNTAGRDCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQGVSGGV 395
            .|.|.|:|.|..||.|:|.|.|.||..||.:..:.|..|:||:|||:||||.|:||||.|.||||
Human   174 RCHCRHHTTGPGCESCRPSHRDWPWRPATPRHPHPCLPCSCNQHARRCRFNSELFRLSGGRSGGV 238

  Fly   396 CQNCRHSTTGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKDGVTGL 460
            |:.|||.|.||:||.|:.||:||.::|:..|:.|:||.|||||::|..||.|||||.||.|||||
Human   239 CERCRHHTAGRHCHYCQPGFWRDPSQPIFSRRACRACQCHPIGATGGTCNQTSGQCTCKLGVTGL 303

  Fly   461 TCNRCARGYQQSRSHIAPCIKQPPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGMAAQSQYY 525
            |||||..|||||||...||.:.|..      |...|..|....|.|              |.|.|
Human   304 TCNRCGPGYQQSRSPRMPCQRIPEA------TTTLATTPGAYSSDP--------------QCQNY 348

  Fly   526 RTEGGRECGKCRVSTKR--LNLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVADYEMD 588
                      |.:|..|  ::|.::|::|:.:.|:|:    :|||.
Human   349 ----------CNMSDTRVHMSLRRYCQQDHVLRAQVL----ASEAA------------------- 380

  Fly   589 QVQPGSARSPITGVYEFQAADYPNPNPNPRGSEMERFDLQIQAVFK-RSRPGESSGAGNVYGMPN 652
                                          |...:|..:::.||:| |::|
Human   381 ------------------------------GPAWQRLAVRVLAVYKQRAQP-------------- 401

  Fly   653 TTLKRGPMTWIIPTKDLECRCPRIRVNRSYLILGRDSEAP-PGYLGIGPHSIVIEWKEDWYRRMK 716
              ::||.....:|..||.|.|.|::....||:||.....| |..|.:..|.:.:.|:..|.|.:|
Human   402 --VRRGDQDAWVPRADLTCGCLRLQPGTDYLLLGSAVGDPDPTRLILDRHGLALPWRPRWARPLK 464

  Fly   717 RFQRRAR 723
            |.|:..|
Human   465 RLQQEER 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	43/235 (18%)
		EGF_Lam	312..357	CDD:238012	21/44 (48%)
		EGF_Lam	369..426	CDD:238012	35/56 (63%)
		EGF_Lam	431..479	CDD:238012	34/47 (72%)
		NTR_netrin-1_like	545..723	CDD:239634	37/179 (21%)
NTN5	NP_665806.1	EGF_Lam	211..265	CDD:238012	34/53 (64%)
		EGF_Lam	274..323	CDD:238012	35/48 (73%)
		NTR_netrin-1_like	360..475	CDD:239634	38/181 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..489		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9319
eggNOG	1	0.900	-	-		E1_KOG3512
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368755at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.880