DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetA and Ntn1

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_446183.2	Gene:	Ntn1 / 114523	RGDID:	619809	Length:	604	Species:	Rattus norvegicus

Alignment Length:	728	Identity:	317/728 - (43%)
Similarity:	412/728 - (56%)	Gaps:	161/728 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLGTTRFSPIQCISNDVYFKMFSQQAPPEDPCYNKAHEPRACIPDFVNAAYDAPVVASSTCGSSG 73
            |:|..|..|        ...||:.||...|||.::...||.|||||||||:...|..|||||...
  Rat    18 LVGAVRGGP--------GLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPP 74

  Fly    74 AQRYC----EYQDHERSCHTCDMTDPLRSFPARSLTDLNNSNNVTCWRSEPVTGSGDNVTLTLSL 134
            | |||    ..::..||||.|:.:||.::.|...||||||.:|:|||:||.......||||||||
  Rat    75 A-RYCVVSERGEERLRSCHLCNSSDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSL 138

  Fly   135 GKKFELTYVILQLCPHAPRPDSMVIYKSTDHGLSWQPFQFFSSQCRRLFGRPARQSTGRHNEHEA 199
            |||||:|||.||.|  :|||:||.||||.|:|.:|.||||:|:|||:::.||.|....:.||.||
  Rat   139 GKKFEVTYVSLQFC--SPRPESMAIYKSMDYGRTWVPFQFYSTQCRKMYNRPHRAPITKQNEQEA 201

  Fly   200 RCSDV---TRPLV-SRIAFSTLEGRPSSRDLDSSPVLQDWVTATDIRVVFHRLQRPDPQALLSLE 260
            .|:|.   .|||. ..||||||:||||:.|.|:|||||||||||||||.|.||.      ....|
  Rat   202 VCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLH------TFGDE 260

  Fly   261 AGGATDLASGKYSVPLANGPAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTD 325
            ....::||...|                            :||:||..|||||||||||::|..|
  Rat   261 NEDDSELARDSY----------------------------YYAVSDLQVGGRCKCNGHAARCVRD 297

  Fly   326 ASGQLNCECSHNTAGRDCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQG 390
            ....|.|:|.|||||.:|:||||||:||||.||||:|||||..||||.|||:||||||:::||..
  Rat   298 RDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGR 362

  Fly   391 VSGGVCQNCRHSTTGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKD 455
            .|||||.||||:|.||:||.||||||||..||:||||.||||||||:|::||.||.|:|||||||
  Rat   363 KSGGVCLNCRHNTAGRHCHYCKEGFYRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKD 427

  Fly   456 GVTGLTCNRCARGYQQSRSHIAPCIKQPPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGMAA 520
            ||||:||||||:|||||||.||||||.|     :......|...:|||
  Rat   428 GVTGITCNRCAKGYQQSRSPIAPCIKIP-----VAPPTTAASSMEEPE----------------- 470

  Fly   521 QSQYYRTEGGRECGK-CRVSTKRL--NLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDV 582
                       :|.. |:.|..:|  |:.|:|::|||:...::..|
  Rat   471 -----------DCDSYCKASKGKLKMNMKKYCRKDYAVQIHILKAD------------------- 505

  Fly   583 ADYEMDQVQPGSARSPITGVYEFQAADYPNPNPNPRGSEMERFDLQIQAVFKRSRPGESSGAGNV 647
                                   :|.|:            .:|.:.|.:|:|:.
  Rat   506 -----------------------KAGDW------------WKFTVNIISVYKQG----------- 524

  Fly   648 YGMPNTTLKRGPMTWIIPTKDLECRCPRIRVNRSYLILGRDSEAPPGYLGI--GPHSIVIEWKED 710
                .:.::||..:..|.::|:.|:||:|:..:.||:|| ::|..|...||  ...|:||:|::.
  Rat   525 ----TSRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLG-NAEDSPDQSGIVADKSSLVIQWRDT 584

  Fly   711 WYRRMKRFQRRAR 723
            |.||:::||:|.:
  Rat   585 WARRLRKFQQREK 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	126/243 (52%)
		EGF_Lam	312..357	CDD:238012	29/44 (66%)
		EGF_Lam	369..426	CDD:238012	40/56 (71%)
		EGF_Lam	431..479	CDD:238012	38/47 (81%)
		NTR_netrin-1_like	545..723	CDD:239634	38/179 (21%)
Ntn1	NP_446183.2	LamNT	46..283	CDD:214532	131/273 (48%)
		EGF_Lam	284..329	CDD:238012	29/44 (66%)
		Laminin_EGF	341..401	CDD:278482	43/59 (73%)
		Laminin_EGF	404..>441	CDD:278482	28/36 (78%)
		NTR_netrin-1_like	487..601	CDD:239634	38/181 (21%)
		Cell attachment site. /evidence=ECO:0000255	530..532		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341025
Domainoid	1	1.000	229	1.000	Domainoid score	I2396
eggNOG	1	0.900	-	-		E1_KOG3512
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	611	1.000	Inparanoid score	I878
OMA	1	1.010	-	-		QHG48023
OrthoDB	1	1.010	-	-		D368755at33208
OrthoFinder	1	1.000	-	-		FOG0003523
OrthoInspector	1	1.000	-	-		otm45248
orthoMCL	1	0.900	-	-		OOG6_104609
Panther	1	1.100	-	-	LDO	PTHR10574
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1381
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770