DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NetA and ntng2b

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	XP_009293374.1	Gene:	ntng2b / 101885039	ZFINID:	ZDB-GENE-110502-1	Length:	1579	Species:	Danio rerio

Alignment Length:	514	Identity:	100/514 - (19%)
Similarity:	163/514 - (31%)	Gaps:	175/514 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 HGLSWQPFQFFSSQCRRLFGRPARQSTGRHNEHEARCSDVTRPLVSRIAFSTLEGRPSSRDLD-- 227
            ||....|           .|..|......||.|    ..|..|..|       ..:|...:.:
Zfish  1128 HGSEHNP-----------HGSEANPHGSEHNSH----GSVANPHGS-------GHKPHGSEYNPH 1170

  Fly   228 ---SSPVLQDWVTATDIRVVFHRLQRP-----DPQALLSLEAGGATDLASGKY-----------S 273
               ::|::.::.|...:       ..|     :|...::...|...|....:|           |
Zfish  1171 GSVANPLVSEYNTHGSV-------ANPHGSAHNPHGSVANPHGSGHDPHGSEYNPHGSVENPQGS 1228

  Fly   274 VPLANGPAGN---NIE------ANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTDASGQ 329
            .|.::|...|   ::|      .|..|.||......|.:....:.......|.|.|..:...||.
Zfish  1229 APNSHGSVANPHGSVENPHASAHNSHGSVANPHGSAHNSHGSVASPHGSAHNSHGSGHNPHGSGH 1293

  Fly   330 LNCECSHNTAGRDCERCKPF-------------------------HFDRPWARATAKEA------ 363
            ...|..|.|.|   .|.||.                         |...|.:..|..|:
Zfish  1294 NPHESGHKTHG---PRHKPHGSVVYPHEPMHNPHGHLHNEPKSESHGPIPESARTTDESVLPISA 1355

  Fly   364 -----------------------------------------------NECKECNCNKHARQCRFN 381
                                                           ::.::|.||.|:.:|.:
Zfish  1356 LESDPNIEMVSIHMSPEEKKEGYTHKALMKFLLSGGKQTVQLKGIIYDDFQDCECNGHSNRCSY- 1419

  Fly   382 MEIFRLSQGVSGGVCQNCRHSTTGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNS 446
            ::...:.      .|.:|:|:|.|:||..|:..:|::.:.......||..|:|:.:||....||.
Zfish  1420 IDFLNIV------TCVSCKHNTRGQNCEHCRMSYYKNMSAEPDDENVCIECNCNALGSVHDRCNG 1478

  Fly   447 TSGQCPCKDGVTGLTCNRCARGYQQSRSHIAPCIKQPPRMIN--MLDTQN--TAPEPDEPESSPG 507
            | |.|.||:|.||:.|:.|..||...:.    |:   |.:.:  :|..||  |..:......:|.
Zfish  1479 T-GFCQCKEGTTGVKCDECLPGYYWKQG----CL---PNVCDDELLLCQNGGTCVQNQRCICTPD 1535

  Fly   508 SGGDRNGAAGMAAQSQYYRTEGGRECGKCRVSTKRLNLN-KFCKRDYAIMAKVIGRDTS 565
            ..|         ...|:.|.|.|::|.  ..|..||:|. ..|    .::|.::|...|
Zfish  1536 FKG---------VLCQHSRCEEGKKCN--GASALRLSLALLLC----PLLATLLGSTAS 1579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	21/135 (16%)
		EGF_Lam	312..357	CDD:238012	14/69 (20%)
		EGF_Lam	369..426	CDD:238012	14/56 (25%)
		EGF_Lam	431..479	CDD:238012	18/47 (38%)
		NTR_netrin-1_like	545..723	CDD:239634	5/22 (23%)
ntng2b	XP_009293374.1	EGF_Lam	<3..34	CDD:238012
		EGF_CA	1408..1457	CDD:304395	14/55 (25%)
		Laminin_EGF	1464..1511	CDD:278482	20/54 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910