DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetA and ntn3

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	XP_004918061.1	Gene:	ntn3 / 100486076	XenbaseID:	XB-GENE-960264	Length:	588	Species:	Xenopus tropicalis

Alignment Length:	731	Identity:	313/731 - (42%)
Similarity:	407/731 - (55%)	Gaps:	172/731 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLLLGTTRFSPIQCISNDVYFKMFSQQAPPEDPCYNKAHEPRACIPDFVNAAYDAPVVASSTCG 70
            |.||:.   |.|:...|....|....||....||||::...||.|:|:|||||::..|.||||||
Frog    10 LFLLVS---FFPMLPHSTSSPFSGQQQQHSIPDPCYDEHGLPRRCVPEFVNAAFNKEVQASSTCG 71

  Fly    71 SSGAQRYCEYQDHERSCHTCDMTDPLRSFPARSLTDLNNSNNVTCWRSEPV-TGSGDNVTLTLSL 134
            ....:.             ||.|||.:|:||..|||||.:.|:||||||.. ..|..||:|||||
Frog    72 RLATRH-------------CDTTDPRKSYPASYLTDLNTAGNMTCWRSETFPRHSSQNVSLTLSL 123

  Fly   135 GKKFELTYVILQLCPHAPRPDSMVIYKSTDHGLSWQPFQFFSSQCRRLFGRPARQSTGRHNEHEA 199
            |||||:|||.||.|  :|||:|:.|:||.|:|.||.|:|::|||||:::|:|:|.|..:.||.||
Frog   124 GKKFEVTYVSLQFC--SPRPESVAIFKSMDYGKSWVPYQYYSSQCRKVYGKPSRASVTKQNEQEA 186

  Fly   200 RCSDVTRPLV----SRIAFSTLEGRPSSRDLDSSPVLQDWVTATDIRVVFHRLQRPDPQALLSLE 260
            .|:|....|.    ..||||||:||||::|||:|||||||:|||||||.|.|     |..|
Frog   187 LCTDGQTELYPLTGGLIAFSTLDGRPSAQDLDNSPVLQDWLTATDIRVFFSR-----PHLL---- 242

  Fly   261 AGGATDLASGKYSVPLANGPAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTD 325
                                      .|...:.:..|.|.:|::.:|.||||||||||||:|..|
Frog   243 --------------------------GNKESEASDEGPGFYYSVGEFQVGGRCKCNGHASRCGKD 281

  Fly   326 ASGQLNCECSHNTAGRDCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQG 390
            ...:|.|:|.|||.|.:|:||||||:||||.||||:|||||..|.||.|||:||||||:::||..
Frog   282 KEARLICDCKHNTEGPECDRCKPFHYDRPWQRATAREANECMACTCNLHARRCRFNMELYKLSGR 346

  Fly   391 VSGGVCQNCRHSTTGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKD 455
            .|||||.||||:|.||:||.||||||||.::.:|.|:.||||||||:|::||.||.|:|||||||
Frog   347 KSGGVCLNCRHNTAGRHCHYCKEGFYRDVSRAITDRRACKACDCHPVGAAGKTCNQTTGQCPCKD 411

  Fly   456 GVTGLTCNRCARGYQQSRSHIAPCIKQPPRMINMLDTQNTAPEP-----DEPESSPGSGGDRNGA 515
            |||||||||||:|||||||.||||||.|.          ..|.|     :||
Frog   412 GVTGLTCNRCAKGYQQSRSPIAPCIKIPA----------VVPTPALTSTEEP------------- 453

  Fly   516 AGMAAQSQYYRTEGGRECGKCRVSTKRLNLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDP 580
               |...||.:...|         ..::||.|:||:|:.:...|:
Frog   454 ---ADCEQYCKPPKG---------NYKINLKKYCKKDFVVQVNVL-------------------- 486

  Fly   581 DVADYEMDQVQPGSARSPITGVYEFQAADYPNPNPNPRGSEMERFDLQIQAVFKRSRPGESSGAG 645
                 ||:.|                            || ..:|.:.|.:|:|
Frog   487 -----EMEMV----------------------------GS-WAKFTVNILSVYK----------- 506

  Fly   646 NVYGMPNTTLKRGPMTWIIPTKDLECRCPRIRVNRSYLILGRDSEAP---PGYLGIGPHSIVIEW 707
                ..:..:|||.....|..|||.|:||:|.::|.||::| .||.|   || |....:|:||:|
Frog   507 ----CRDDRIKRGDNFLWIHIKDLSCKCPKILLSRRYLVMG-SSEGPSERPG-LTADKNSMVIQW 565

  Fly   708 KEDWYRRMKRFQRRAR 723
            ::.|.||:::.|||.:
Frog   566 RDAWTRRLRKLQRREK 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	115/240 (48%)
		EGF_Lam	312..357	CDD:238012	29/44 (66%)
		EGF_Lam	369..426	CDD:238012	37/56 (66%)
		EGF_Lam	431..479	CDD:238012	39/47 (83%)
		NTR_netrin-1_like	545..723	CDD:239634	46/180 (26%)
ntn3	XP_004918061.1	Laminin_N	52..267	CDD:395009	118/264 (45%)
		EGF_Lam	268..313	CDD:238012	29/44 (66%)
		Laminin_EGF	325..376	CDD:395007	36/50 (72%)
		Laminin_EGF	388..>425	CDD:395007	29/36 (81%)
		NTR_netrin-1_like	471..585	CDD:239634	46/182 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I2507
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	619	1.000	Inparanoid score	I870
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368755at33208
OrthoFinder	1	1.000	-	-		FOG0003523
OrthoInspector	1	1.000	-	-		otm48313
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17280
SonicParanoid	1	1.000	-	-		X1381
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.090