Protein Alignment NetA and ntn3

DIOPT Version :10

• Sequence 1: NP_511154.3
• Gene: NetA / 32398
• FlyBaseID: FBgn0015773
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: XP_004918061.1
• Gene: ntn3 / 100486076
• XenbaseID: XB-GENE-960264
• Length: 588
• Species: Xenopus tropicalis
• Alignment Length: 731
• Identity: 313/731 - (42%)
• Similarity: 407/731 - (55%)
• Gaps: 172/731 - (23%)

  Fly     6 LLLLLGTTRFSPIQCISNDVYFKMFSQQAPPEDPCYNKAHEPRACIPDFVNAAYDAPVVASSTCG 70
            |.||:.   |.|:...|....|....||....||||::...||.|:|:|||||::..|.||||||
 Frog    10 LFLLVS---FFPMLPHSTSSPFSGQQQQHSIPDPCYDEHGLPRRCVPEFVNAAFNKEVQASSTCG 71

  Fly    71 SSGAQRYCEYQDHERSCHTCDMTDPLRSFPARSLTDLNNSNNVTCWRSEPV-TGSGDNVTLTLSL 134
            ....:.             ||.|||.:|:||..|||||.:.|:||||||.. ..|..||:|||||
 Frog    72 RLATRH-------------CDTTDPRKSYPASYLTDLNTAGNMTCWRSETFPRHSSQNVSLTLSL 123

  Fly   135 GKKFELTYVILQLCPHAPRPDSMVIYKSTDHGLSWQPFQFFSSQCRRLFGRPARQSTGRHNEHEA 199
            |||||:|||.||.|  :|||:|:.|:||.|:|.||.|:|::|||||:::|:|:|.|..:.||.||
 Frog   124 GKKFEVTYVSLQFC--SPRPESVAIFKSMDYGKSWVPYQYYSSQCRKVYGKPSRASVTKQNEQEA 186

  Fly   200 RCSDVTRPLV----SRIAFSTLEGRPSSRDLDSSPVLQDWVTATDIRVVFHRLQRPDPQALLSLE 260
            .|:|....|.    ..||||||:||||::|||:|||||||:|||||||.|.|     |..|
 Frog   187 LCTDGQTELYPLTGGLIAFSTLDGRPSAQDLDNSPVLQDWLTATDIRVFFSR-----PHLL---- 242

  Fly   261 AGGATDLASGKYSVPLANGPAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTD 325
                                      .|...:.:..|.|.:|::.:|.||||||||||||:|..|
 Frog   243 --------------------------GNKESEASDEGPGFYYSVGEFQVGGRCKCNGHASRCGKD 281

  Fly   326 ASGQLNCECSHNTAGRDCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQG 390
            ...:|.|:|.|||.|.:|:||||||:||||.||||:|||||..|.||.|||:||||||:::||..
 Frog   282 KEARLICDCKHNTEGPECDRCKPFHYDRPWQRATAREANECMACTCNLHARRCRFNMELYKLSGR 346

  Fly   391 VSGGVCQNCRHSTTGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKD 455
            .|||||.||||:|.||:||.||||||||.::.:|.|:.||||||||:|::||.||.|:|||||||
 Frog   347 KSGGVCLNCRHNTAGRHCHYCKEGFYRDVSRAITDRRACKACDCHPVGAAGKTCNQTTGQCPCKD 411

  Fly   456 GVTGLTCNRCARGYQQSRSHIAPCIKQPPRMINMLDTQNTAPEP-----DEPESSPGSGGDRNGA 515
            |||||||||||:|||||||.||||||.|.          ..|.|     :||
 Frog   412 GVTGLTCNRCAKGYQQSRSPIAPCIKIPA----------VVPTPALTSTEEP------------- 453

  Fly   516 AGMAAQSQYYRTEGGRECGKCRVSTKRLNLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDP 580
               |...||.:...|         ..::||.|:||:|:.:...|:
 Frog   454 ---ADCEQYCKPPKG---------NYKINLKKYCKKDFVVQVNVL-------------------- 486

  Fly   581 DVADYEMDQVQPGSARSPITGVYEFQAADYPNPNPNPRGSEMERFDLQIQAVFKRSRPGESSGAG 645
                 ||:.|                            || ..:|.:.|.:|:|
 Frog   487 -----EMEMV----------------------------GS-WAKFTVNILSVYK----------- 506

  Fly   646 NVYGMPNTTLKRGPMTWIIPTKDLECRCPRIRVNRSYLILGRDSEAP---PGYLGIGPHSIVIEW 707
                ..:..:|||.....|..|||.|:||:|.::|.||::| .||.|   || |....:|:||:|
 Frog   507 ----CRDDRIKRGDNFLWIHIKDLSCKCPKILLSRRYLVMG-SSEGPSERPG-LTADKNSMVIQW 565

  Fly   708 KEDWYRRMKRFQRRAR 723
            ::.|.||:::.|||.:
 Frog   566 RDAWTRRLRKLQRREK 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_511154.3	LamNT	44..280	CDD:214532	115/240 (48%)
		EGF_Lam	312..357	CDD:238012	29/44 (66%)
		EGF_Lam	369..426	CDD:238012	37/56 (66%)
		EGF_Lam	431..479	CDD:238012	39/47 (83%)
		NTR_netrin-1_like	545..723	CDD:239634	46/180 (26%)
ntn3	XP_004918061.1	LamNT	45..267	CDD:214532	121/271 (45%)
		EGF_Lam	268..313	CDD:238012	29/44 (66%)
		Laminin_EGF	325..376	CDD:395007	36/50 (72%)
		Laminin_EGF	388..>425	CDD:395007	29/36 (81%)
		NTR_netrin-1_like	471..585	CDD:239634	46/182 (25%)