DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NetA and ushbp1

DIOPT Version :9

Sequence 1:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	XP_005155764.1	Gene:	ushbp1 / 100148935	ZFINID:	ZDB-GENE-121024-2	Length:	649	Species:	Danio rerio

Alignment Length:	256	Identity:	53/256 - (20%)
Similarity:	91/256 - (35%)	Gaps:	67/256 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   459 GLTCNRCARGYQQSRSHIAPCIKQP-----PRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGM 518
            |::|:........|....:||...|     |    :|..:..:..||.|  .|.|..|      .
Zfish   224 GVSCSPPVSPSLSSSRTSSPCFSSPSYPGSP----LLSRKLPSSRPDSP--LPPSTID------S 276

  Fly   519 AAQSQYYRTEGGRECGKCRVSTKRLNLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVA 583
            ..|::   ||..:.|           |.:...|:..:.|.::.|...||.:|..:.|:..|....
Zfish   277 VLQAE---TEKMQRC-----------LERLKARNERLSAALVRRKGESEQLSMSLSRQEADSSAL 327

  Fly   584 DYEMDQVQP-GSARSPITGVYEFQ----AADYPNPNPNPRGSEMERFDLQIQAVFKRSRPGESSG 643
            ...:...:. ..|.|.:..:||.:    ||....|.|:...|:.|      .:..:.|.|.|  |
Zfish   328 HMALAYCEECEEAYSDLLSLYEARKQQHAATNSTPQPDLSKSKEE------NSKCESSSPPE--G 384

  Fly   644 AGNVYGMPNTTLKR------GPMTWIIPTKDLECRCPRIRVNRSYLIL------GRDSEAP 692
            |.:  ..||:..|:      |.:|.         |..|::.:|:.:.:      |.|..:|
Zfish   385 AAD--ARPNSLSKQEFEDKAGVITQ---------RISRLQQDRAAVCIPQRGKAGEDKISP 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetA	NP_001285243.1	LamNT	44..280	CDD:214532
		EGF_Lam	312..357	CDD:238012
		EGF_Lam	369..426	CDD:238012
		EGF_Lam	431..479	CDD:238012	3/19 (16%)
		NTR_netrin-1_like	545..723	CDD:239634	35/165 (21%)
ushbp1	XP_005155764.1	MCC-bdg_PDZ	284..348	CDD:287477	12/74 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3512
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900