DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sbm and SLC7A5

DIOPT Version :9

Sequence 1:	NP_727785.1	Gene:	sbm / 32397	FlyBaseID:	FBgn0030574	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_016879224.1	Gene:	SLC7A5 / 8140	HGNCID:	11063	Length:	509	Species:	Homo sapiens

Alignment Length:	469	Identity:	196/469 - (41%)
Similarity:	290/469 - (61%)	Gaps:	13/469 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 GPE-------APETDSSGTGRMRKPLERNGST---QNHVVHLERRLGLFSGVALIVGTMIGSGIF 103
            ||:       |.|.......:|......:||.   :...|.|:|.:.|.:|||:||||:||||||
Human     5 GPKRRALAAPAAEEKEEAREKMLAAKSADGSAPAGEGEGVTLQRNITLLNGVAIIVGTIIGSGIF 69

  Fly   104 VSPSGLLVRTGSVGVSFIIWLACGVLSLLGALAYAELGTMNTSSGAEWAYFMDAYGPAPAFLFSW 168
            |:|:|:|...||.|::.::|.||||.|::|||.||||||..:.||.::||.::.||..||||..|
Human    70 VTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLW 134

  Fly   169 VSTLVLKPSQMAIICLSFAQYAVEAFVTECDPPRGVVKMVALVAIVMILFVNCYSVNLGMAVQNV 233
            :..|:::||...|:.|.||.|.::.....|..|....|:||.:.::::..||||||.....||:.
Human   135 IELLIIRPSSQYIVALVFATYLLKPLFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDA 199

  Fly   234 FTAAKLVAVVVVICGGAWKLMQGNTQHL--SNAFNGPMPNVGAIATAFYTGLWAYDGWNNLNYVT 296
            |.||||:|:.::|..|..::.:|:..:|  :.:|.|...:||.|..|.|:||:||.|||.||:||
Human   200 FAAAKLLALALIILLGFVQIGKGDVSNLDPNFSFEGTKLDVGNIVLALYSGLFAYGGWNYLNFVT 264

  Fly   297 EEIKNPSKNLPRSIIIGIPLVTLCYALINISYLAAMSPQEMIESEAVAVTFGNRILGALAWLMPL 361
            ||:.||.:|||.:|||.:|:|||.|.|.|::|...:|.::|:.||||||.|||..||.::|::|:
Human   265 EEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPV 329

  Fly   362 SVTISTFGSANGTLFAAGRLCFAASREGHLLDILSYVHVRRLTPAPGLIFHSLIASAMVLHGTID 426
            .|.:|.|||.||:||.:.||.|..||||||..|||.:|.:.|||.|.|:|..::.........|.
Human   330 FVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIF 394

  Fly   427 SLIDFFSFTAWIFYGGAMLALIVMRYTKPNYPRPYKVPIIIPVVVLVISVYLVAAPIFETPRVEY 491
            |:|:||||..|:....|::.:|.:|:.||...||.||.:.:||..::..::|:|...::|| ||.
Human   395 SVINFFSFFNWLCVALAIIGMIWLRHRKPELERPIKVNLALPVFFILACLFLIAVSFWKTP-VEC 458

  Fly   492 LYALLFIFAGLIFY 505
            ......|.:||..|
Human   459 GIGFTIILSGLPVY 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbm	NP_727785.1	2A0308	53..532	CDD:273332	193/458 (42%)
SLC7A5	XP_016879224.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D621852at2759
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760