DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sbm and SLC7A4

DIOPT Version :9

Sequence 1:	NP_727785.1	Gene:	sbm / 32397	FlyBaseID:	FBgn0030574	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_004164.2	Gene:	SLC7A4 / 6545	HGNCID:	11062	Length:	635	Species:	Homo sapiens

Alignment Length:	438	Identity:	110/438 - (25%)
Similarity:	187/438 - (42%)	Gaps:	76/438 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 KPLERNGSTQNHVVHLERRLGLFSGVALIVGTMIGSGIFV----------SPSGLLVRTGSVGVS 119
            ||||  .||..  ..|.|.|.......|.||.|:|||::|          .|:.||    |.||:
Human    22 KPLE--DSTME--TSLRRCLSTLDLTLLGVGGMVGSGLYVLTGAVAKEVAGPAVLL----SFGVA 78

  Fly   120 FIIWLACGVLSLLGALAYAELGTMNTSSGAEWAYFMDAYGPAPAFLFSWVSTLVLKPSQMAIICL 184
                   .|.|||.||.|||.|.....:|:.:.:...:.|...|||..| :.|:......|.:..
Human    79 -------AVASLLAALCYAEFGARVPRTGSAYLFTYVSMGELWAFLIGW-NVLLEYIIGGAAVAR 135

  Fly   185 SFAQYAVEAF------VTECDPPRGVVKMVA-----LVAIVMIL---FVNCYSVNLGMAVQNVFT 235
            :::.|....|      .||.......|.::.     |.|.:::|   ||:| ...:...:.:.|:
Human   136 AWSGYLDSMFSHSIRNFTETHVGSWQVPLLGHYPDFLAAGIILLASAFVSC-GARVSSWLNHTFS 199

  Fly   236 AAKLVAVVVVICGG-------AWKLMQGNTQHLSNAFNGPMPNVGAIATAFYTGLWAYDGWNNLN 293
            |..|:.::.::..|       .|...:|.....  .|:|.|   ...|:.||    |:.|::.:.
Human   200 AISLLVILFIVILGFILAQPHNWSADEGGFAPF--GFSGVM---AGTASCFY----AFVGFDVIA 255

  Fly   294 YVTEEIKNPSKNLPRSIIIGIPLVTLCYALINISYLAAMSPQEMIESE-AVAVTF---GNRILGA 354
            ..:||.:||.:::|.:|.|.:.:....|.|:: :.|..|.|...::.: |:|..|   |.|..|.
Human   256 ASSEEAQNPRRSVPLAIAISLAIAAGAYILVS-TVLTLMVPWHSLDPDSALADAFYQRGYRWAGF 319

  Fly   355 LAWLMPLSVTISTFGSAN----GTLFAAGRLCFAASREGHLLDILSYVHVRRLTPAPGLIFHSLI 415
            :       |...:..:.|    ..||:..|:.:|.:.:|....:.::||.|...|..|.:...|:
Human   320 I-------VAAGSICAMNTVLLSLLFSLPRIVYAMAADGLFFQVFAHVHPRTQVPVAGTLAFGLL 377

  Fly   416 ASAMVLHGTIDSLIDFFSFTAWIFYGGAMLALIVMRYTK---PNYPRP 460
            .:.:.|...::||:.|.|....:.|.....::||:|:.|   |:.|.|
Human   378 TAFLALLLDLESLVQFLSLGTLLAYTFVATSIIVLRFQKSSPPSSPGP 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbm	NP_727785.1	2A0308	53..532	CDD:273332	110/438 (25%)
SLC7A4	NP_004164.2	2A0303	26..592	CDD:273330	106/432 (25%)
SLC7A4	NP_004164.2	AA_permease_C	540..590	CDD:290617
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920