DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sbm and slc7a6

DIOPT Version :9

Sequence 1:	NP_727785.1	Gene:	sbm / 32397	FlyBaseID:	FBgn0030574	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_005166451.1	Gene:	slc7a6 / 57957	ZFINID:	ZDB-GENE-000607-21	Length:	494	Species:	Danio rerio

Alignment Length:	514	Identity:	190/514 - (36%)
Similarity:	302/514 - (58%)	Gaps:	42/514 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NSTDNNRGHNVPTKTTSNGTMCANGSLGTEGPEAPETDSSGTGRMRKPLERNGSTQNHVVHLERR 83
            |:||:.:               .||.     ||:|       ..:.||.|.        :.|::.
Zfish     3 NNTDSKK---------------MNGQ-----PESP-------AALSKPRES--------MQLKKE 32

  Fly    84 LGLFSGVALIVGTMIGSGIFVSPSGLLVRTGSVGVSFIIWLACGVLSLLGALAYAELGTMNTSSG 148
            :.|.:||:||||.||||||||||.|:|:.:.|.|:|.:||...|:.|::|||.||||||..|.||
Zfish    33 ISLLNGVSLIVGNMIGSGIFVSPKGVLIYSASYGLSLVIWAIGGIFSVVGALCYAELGTTITKSG 97

  Fly   149 AEWAYFMDAYGPAPAFLFSWVSTLVLKPSQMAIICLSFAQYAVEAFVTECDPPRGVVKMVALVAI 213
            |.:||.::::|...||:..|.|.|:::|:..|:|.::||.|.|:.....|:||....:::|...|
Zfish    98 ASYAYILESFGGFIAFIRLWTSLLIIEPTSQAVIAITFANYLVQPLFPTCEPPYSASRLIAAACI 162

  Fly   214 VMILFVNCYSVNLGMAVQNVFTAAKLVAVVVVICGGAWKLMQGNTQHLSNAFNGPMPNVGAIATA 278
            .::.|:|...|..|..||:|||.||::|::|:|..|..||.||.|.:..::|.|...:.|.||.|
Zfish   163 CLLTFINSAYVKWGTRVQDVFTYAKVLALIVIIITGIVKLCQGFTINFEDSFQGSSRDPGGIALA 227

  Fly   279 FYTGLWAYDGWNNLNYVTEEIKNPSKNLPRSIIIGIPLVTLCYALINISYLAAMSPQEMIESEAV 343
            .|:.|::|.||:.||:||||||||.:|||.||.|.:|:||:.|.|.|::|.|.:....::.|:||
Zfish   228 LYSALFSYSGWDTLNFVTEEIKNPERNLPLSIAISMPIVTIIYILTNVAYYAVLDMSAILASDAV 292

  Fly   344 AVTFGNRILGALAWLMPLSVTISTFGSANGTLFAAGRLCFAASREGHLLDILSYVHVRRLTPAPG 408
            ||||.:..||.::|.:|::|.:|.:|..|.::.||.||.|..:|||||.|.||.:|:.|.||.|.
Zfish   293 AVTFADHTLGVMSWTIPIAVALSCYGGLNSSIIAASRLFFVGAREGHLPDALSMIHIERFTPVPA 357

  Fly   409 LIFHSLIASAMVLHGTIDSLIDFFSFTAWIFYGGAMLALIVMRYTKPNYPRPYKVPIIIPVVVLV 473
            |:|:..:|...:....:..||:::||:.|.|.|.::...|.:|:.:|:.|||.|:.::.|::..:
Zfish   358 LLFNCAMALIYLTVEDVFQLINYYSFSYWFFVGLSIAGQIYLRWKEPDRPRPLKLSLVYPIIFCL 422

  Fly   474 ISVYLVAAPIFETPRVEYLYALLFIFAGLIFYVPFVKLGMTPR------FMNKVTLFFQ 526
            ..|:|||.|:: :..:..|..:....:|:..|...:.|..:.|      .::.:|.|.|
Zfish   423 CVVFLVAVPLY-SDTLNSLIGIAIALSGVPVYFLGIHLPESKRPPIITKLLSAITRFTQ 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbm	NP_727785.1	2A0308	53..532	CDD:273332	183/480 (38%)
slc7a6	XP_005166451.1	2A0308	2..489	CDD:273332	190/514 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D621852at2759
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.760