DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sbm and slc7a6

DIOPT Version :9

Sequence 1:	NP_727785.1	Gene:	sbm / 32397	FlyBaseID:	FBgn0030574	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001017197.1	Gene:	slc7a6 / 549951	XenbaseID:	XB-GENE-963214	Length:	514	Species:	Xenopus tropicalis

Alignment Length:	520	Identity:	190/520 - (36%)
Similarity:	297/520 - (57%)	Gaps:	34/520 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 TDNNRGHNVPTKTTSNGTMCANGSLGTEGPEAPETDSSGTGRMRKPLERNGSTQNHVVHLERRLG 85
            |:|   ..||..:||.|                :|..:.|...:.|.:        .:.|::.:.
Frog     4 TEN---QTVPLNSTSPG----------------DTSHTSTSDSKDPQD--------TMQLKKEIS 41

  Fly    86 LFSGVALIVGTMIGSGIFVSPSGLLVRTGSVGVSFIIWLACGVLSLLGALAYAELGTMNTSSGAE 150
            |.:||:||||.||||||||||.|:|:.:.|.|:|.|:|...|:.|::|||.||||||....|||.
Frog    42 LLNGVSLIVGNMIGSGIFVSPKGVLIYSASYGLSLILWSLGGIFSVIGALCYAELGTTIKKSGAS 106

  Fly   151 WAYFMDAYGPAPAFLFSWVSTLVLKPSQMAIICLSFAQYAVEAFVTECDPPRGVVKMVALVAIVM 215
            :||.::|:|...||:..|.|.|:::|:..|:|.::||.|.|:.....|.||....:::|...:.:
Frog   107 YAYILEAFGDFVAFIRLWTSLLIIEPTSQAVIAITFANYLVQPVFPSCYPPYMASRLIAAACVCL 171

  Fly   216 ILFVNCYSVNLGMAVQNVFTAAKLVAVVVVICGGAWKLMQGNTQHLSNAFNGPMPNVGAIATAFY 280
            |.|:||..|..|..||::||.||::|::.:|..|..||.||.|::..::|.|...:.|.|:...|
Frog   172 ITFINCAYVKWGTRVQDLFTYAKVIALIAIIITGIVKLSQGQTENFEDSFAGSSWDAGEISLGLY 236

  Fly   281 TGLWAYDGWNNLNYVTEEIKNPSKNLPRSIIIGIPLVTLCYALINISYLAAMSPQEMIESEAVAV 345
            :.|::|.||:.||:||||||||.:|||.||.|.:||||:.|.|.|::|...:....::.||||||
Frog   237 SALFSYSGWDTLNFVTEEIKNPERNLPLSIGISMPLVTIIYILTNVAYYTVLDFNAVVASEAVAV 301

  Fly   346 TFGNRILGALAWLMPLSVTISTFGSANGTLFAAGRLCFAASREGHLLDILSYVHVRRLTPAPGLI 410
            ||.:.:.|..:|.:|::|.:|.||..|.::.||.||.|..:|||||.|:|..:|..|.||.|.|:
Frog   302 TFADMVYGVFSWTIPVAVALSCFGGLNSSILAASRLFFVGAREGHLPDMLCLIHQERFTPVPALL 366

  Fly   411 FHSLIASAMVLHGTIDSLIDFFSFTAWIFYGGAMLALIVMRYTKPNYPRPYKVPIIIPVVVLVIS 475
            |:.:.....:....:..||:::||:.|.|.|.::...|.:|..||..|||.|:.:..|:|..:.:
Frog   367 FNCVATLIYLAVKDVFQLINYYSFSYWFFVGLSIAGQIYLRIKKPELPRPVKLSLFYPIVFCLCT 431

  Fly   476 VYLVAAPIFETPRVEYLYALLFIFAGLIFYVPFVKL--GMTPRFMNKVTLFF----QLLLEVVPT 534
            |:||..|:: :..|..|..:....:|:..|...:.|  ...|.|:::|..|.    |::...|.|
Frog   432 VFLVIVPLY-SDTVNSLIGIGIALSGIPVYFMGIYLPESKRPPFISRVLAFLTRRTQMIFNCVLT 495

Fly 535 534
Frog 496 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbm	NP_727785.1	2A0308	53..532	CDD:273332	181/484 (37%)
slc7a6	NP_001017197.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		9/45 (20%)
slc7a6	NP_001017197.1	2A0308	29..496	CDD:273332	181/476 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D621852at2759
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960