DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sbm and Slc7a8

DIOPT Version :9

Sequence 1:	NP_727785.1	Gene:	sbm / 32397	FlyBaseID:	FBgn0030574	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_058668.1	Gene:	Slc7a8 / 50934	MGIID:	1355323	Length:	531	Species:	Mus musculus

Alignment Length:	533	Identity:	209/533 - (39%)
Similarity:	312/533 - (58%)	Gaps:	51/533 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LQKNACKNNSTDNNRGHNVPTKTTSNGTMCANGSLGTEGPEAPETDSSGTGRMRKPLERNGSTQN 75
            ::|.|.:.|:|..|.    |...||              ||| |..|.|.|
Mouse     1 MEKGARQRNNTAKNH----PGSDTS--------------PEA-EASSGGGG-------------- 32

  Fly    76 HVVHLERRLGLFSGVALIVGTMIGSGIFVSPSGLLVRTGSVGVSFIIWLACGVLSLLGALAYAEL 140
              |.|::.:||.|...:|||.:|||||||||.|:|...||||::.|:|:..|:::.:|||.||||
Mouse    33 --VALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGIITAVGALCYAEL 95

  Fly   141 GTMNTSSGAEWAYFMDAYGPAPAFLFSWVSTLVLKPSQMAIICLSFAQYAVEAFVTECDPPRGVV 205
            |.....||.:::|..|.:|....||..|::.||:.|:..|:|.|:|:.|.::.....|.||...:
Mouse    96 GVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGL 160

  Fly   206 KMVALVAIVMILFVNCYSVNLGMAVQNVFTAAKLVAVVVVICGGAWKLMQGNTQHL--SNAF-NG 267
            :::|.:.::::.:|||.||.....||::|||.||:|:.::|..|..::.:|....|  .||| |.
Mouse   161 RLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEFFWLEPKNAFENF 225

  Fly   268 PMPNVGAIATAFYTGLWAYDGWNNLNYVTEEIKNPSKNLPRSIIIGIPLVTLCYALINISYLAAM 332
            ..|::|.:|.||..|.:||.|||.|||||||:.:|.|||||:|.|.|||||..|...||:|:.||
Mouse   226 QEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANIAYVTAM 290

  Fly   333 SPQEMIESEAVAVTFGNRILGALAWLMPLSVTISTFGSANGTLFAAGRLCFAASREGHLLDILSY 397
            ||||::.|.|||||||.::||.:||:||:||.:||||..||:||.:.||.||.:|||||..:|:.
Mouse   291 SPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAM 355

  Fly   398 VHVRRLTPAPGLIFHSLIASAMVLHGTIDSLIDFFSFTAWIFYGGAMLALIVMRYTKPNYPRPYK 462
            :||:|.||.|.|:|..|....|::...:.:||::..|..::|||..:...||:|:.||:.|||.|
Mouse   356 IHVKRCTPIPALLFTCLSTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIK 420

  Fly   463 VPIIIPVVVLVISVYLVAAPIFETPRVEYLYALLFIFAGLIFYVPFVKLGM----TPR----FMN 519
            |.::.|::.|:...:|:...::..|.|..: .|..:..|    ||...||:    .|:    |:.
Mouse   421 VSLLFPIIYLLFWAFLLIFSLWSEPVVCGI-GLAIMLTG----VPVYFLGVYWQHKPKCFNDFIK 480

  Fly   520 KVTLFFQLLLEVV 532
            .:||..|.:..||
Mouse   481 SLTLVSQKMCVVV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbm	NP_727785.1	2A0308	53..532	CDD:273332	196/489 (40%)
Slc7a8	NP_058668.1	2A0308	1..497	CDD:273332	209/533 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		12/46 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D621852at2759
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.760