DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sbm and Slc7a11

DIOPT Version :9

Sequence 1:	NP_727785.1	Gene:	sbm / 32397	FlyBaseID:	FBgn0030574	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_038958186.1	Gene:	Slc7a11 / 310392	RGDID:	1309275	Length:	505	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	189/492 - (38%)
Similarity:	293/492 - (59%)	Gaps:	31/492 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 MRKP----LERNGSTQNHV-----------------VHLERRLGLFSGVALIVGTMIGSGIFVSP 106
            :|||    :.:.|..|.:|                 |.|::::.|..||::|:||:||||||:||
  Rat     2 VRKPVVATISKGGYLQGNVSGRLPSVGDQEPPGHEKVVLKKKITLLRGVSIIIGTVIGSGIFISP 66

  Fly   107 SGLLVRTGSVGVSFIIWLACGVLSLLGALAYAELGTMNTSSGAEWAYFMDAYGPAPAFLFSWVST 171
            .|:|..|||||:|.:.|.|||||||.|||:||||||....||..:.|.::.:||..||:..||..
  Rat    67 KGILQNTGSVGMSLVFWSACGVLSLFGALSYAELGTSIKKSGGHYTYILEVFGPLLAFVRVWVEL 131

  Fly   172 LVLKPSQMAIICLSFAQYAVEAFVTECDPPRGVVKMVALVAIVMILFVNCYSVNLGMAVQNVFTA 236
            ||::|...|:|.|:|.:|.:|.|..:|:.|...:|:|..|.|.:::.:|..||:....:|...|.
  Rat   132 LVIRPGATAVISLAFGRYILEPFFIQCEIPELAIKLVTAVGITVVMVLNSTSVSWSARIQIFLTF 196

  Fly   237 AKLVAVVVVICGGAWKLMQGNTQHLSNAFNGPMPNVGAIATAFYTGLWAYDGWNNLNYVTEEIKN 301
            .||.|::::|..|..:|::|.|.|..:||:|...|:..:..|||.|::||.||..||::|||:.|
  Rat   197 CKLTAILIIIVPGVIQLIKGQTHHFKDAFSGRDTNLMGLPLAFYYGMYAYAGWFYLNFITEEVDN 261

  Fly   302 PSKNLPRSIIIGIPLVTLCYALINISYLAAMSPQEMIESEAVAVTFGNRILGALAWLMPLSVTIS 366
            |.|.:|.:|.|.:.::|:.|.|.|::|...:|.:|:::|.||||||..|:||..:..:|:.|.:|
  Rat   262 PEKTIPLAICISMAIITVGYVLTNVAYFTTISAEELLQSSAVAVTFSERLLGKFSLAVPIFVALS 326

  Fly   367 TFGSANGTLFAAGRLCFAASREGHLLDILSYVHVRRLTPAPGLIFHSLIASAMVLHGTIDSLIDF 431
            .|||.||.:||..||.:.|||||||.:|||.:||.:.||.|.:|....:...|:..|.:.||::|
  Rat   327 CFGSMNGGVFAVSRLFYVASREGHLPEILSMIHVHKHTPLPAVIVLHPLTMIMLFSGDLYSLLNF 391

  Fly   432 FSFTAWIFYGGAMLALIVMRYTKPNYPRPYKVPIIIPVVVLVISVYLVAAPIFETP---RVEYLY 493
            .||..|:|.|.|:..||.:||.:|:..||:|||:.||.:.....:::|...::..|   .|.:|.
  Rat   392 LSFARWLFMGLAVAGLIYLRYKRPDMHRPFKVPLFIPALFSFTCLFMVVLSLYSDPFSTGVGFLI 456

  Fly   494 ALLFIFAGLIFYVPFVKLGMTPRFMNKVT---LFFQL 527
            .|    .|:..|..|:.....|::..:::   |.|.|
  Rat   457 TL----TGVPAYYLFIVWDKKPKWFRRLSVNNLHFSL 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbm	NP_727785.1	2A0308	53..532	CDD:273332	189/492 (38%)
Slc7a11	XP_038958186.1	2A0308	1..482	CDD:273332	186/483 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D621852at2759
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.830